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The author discusses a recent paper published in Nature that shows that a hyperactive allele of the tumor suppressor p53 leads to the development of some premature aging phenotypes in mice. This new discovery is discussed in light of previous findings related to mechanisms of aging.  相似文献   
63.
The immaturity of the evidence base in some areas of child welfare practice demands that practitioners approach the development and refinement of practice in a systematic way that explicitly seeks to build on and learn from experience. The efforts of public child welfare agencies in Boston and Cleveland show that it is possible to draw on a broader base of knowledge and experience while responding to unique conditions and circumstances in each agency's community.  相似文献   
64.
S Eilon  Bela Gold  Judith Soesan 《Omega》1975,3(3):329-343
This paper describes a case study in the application of a productivity analysis model in a plant producing industrial gases. Although the process is a relatively simple one, several inputs (labour, electricity, capital and some materials) and several outputs (liquid and gaseous oxygen, gaseous nitrogen, argon and a hydrogen-nitrogen mixture) are involved. The case study demonstrates how measures of total input and total output can be applied and analyses the performance of the plant over a 15-month period in terms of a variety of managerial control ratios.  相似文献   
65.
The Interpretation of Line of Regard by Prelingually Deaf Children   总被引:2,自引:0,他引:2  
The ability of 5- to 12-year-old deaf children to utilise and interpret another person's visual line of regard (where the eyes are looking) was studied in four experiments using cartoon faces. The children had little difficulty in determining whether or not a face was looking directly at them. They had more difficulty, however, with more complex tasks requiring them to infer mental states of desire and intention from line of regard and to ignore line of regard when it was inappropriate to attend to this cue. Deaf children raised in a hearing environment appear to have more difficulty with these more complex tasks than hearing children. The results are discussed in terms of the special difficulties facing some deaf children in the development of skills involving utilisation of line of regard and the implications for the development of joint attentional behaviour, theory of mind and dyadic social interaction in deaf and hearing children.  相似文献   
66.
A training program was devised for selected child welfare workers to conduct parent groups in the Missouri Neglect Demonstration Project. Welfare workers were trained to conduct parent groups that focused on parenting skills, self-advocacy, and social and economic resources. In contrast to case manager referrals, the workshops provided education directly and helped parents to develop resources. One of the goals was to have staff and parents collaborate to improve referral services and resources. The importance of this type of program was demonstrated by a literature review of parent trainings which found that: (a) few programs specifically addressed child neglect; (b) outcome evaluations of programs were scarce; and (c) a national extension study supported topics chosen.  相似文献   
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We focus here on the retention of highly qualified women scientists in science‐based employment in England and Wales. Using linked Census records from the Longitudinal Study 1971–1991 we show that women's education and employment rates in science, engineering and technology increased somewhat, although some fields show persistently low representation. We then compare retention in employing women with health‐related degrees with that of women with degrees in science, engineering and technology, showing that the latter group has markedly lower retention rates. Those who stay on in science‐based employment have children later than other types of graduate and their rates of non‐motherhood are higher. Four‐fifths of women in health‐related occupations were mothers, compared to only two‐fifths in science, engineering and technology. Our findings have implications for policymakers who wish to make best use of the knowledge base: attention should be paid to retention, as well as the more usual focus on qualifications and recruitment. The findings also suggest the potential for institutionally based theories to explain why highly qualified women have such low retention rates in science‐based employment.  相似文献   
69.
Migrants have been found to be at enhanced risk for the Human Immune Deficiency Virus (HIV) in comparison with settled populations. As they migrate, they often bring with them their traditions and cultural values, which may influence the ways they access or make sense of health promotion interventions in the host country. In the diaspora, should they experience compromised citizenship, marked by an unresolved immigration status, some may need to remain invisible and this may include not accessing or presenting late for vital health care interventions. Addressing the needs of such invisible populations is key to health promotion work and paramount to public health interests. This paper describes how ever‐changing “traditions”, in particular the notions of Pachedu and Zenzele, were harnessed to develop ethically grounded sexual health care interventions amongst Zimbabweans in Luton, Bedfordshire, England. These interventions were delivered in mundane settings that formed some of the key everyday networks of this population. The reinvention of “tradition” for the purposes of delivering health and social care interventions has been one of the cornerstones of health promotion interventions in Africa, where the rates of HIV are some of the highest in the world. The concept of Pachedu harnessed confidentiality in the delivery of sexual health interventions with Zenzele calling for communal involvement in such initiatives. A key point that resulted in the success of this intervention was partnership work between statutory providers and the local Zimbabwean population throughout the project’s life span. Rather than being construed as passive recipients of health and social care interventions, local Zimbabweans and their statutory partners were engaged in mutual capacity building initiatives. Local Zimbabweans were also engaged and consulted throughout, from the conceptualization of the project, delivery, monitoring, and dissemination of the findings.  相似文献   
70.
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