Statistical Properties of a Modified Accelerated Design for Phase I Cancer Clinical Trials

We consider the semiparametric profile likelihood inference for the distribution function under doubly censored data. For further developments of the statistical inference based on the profile likelihood ratio and alternative tools such as the score or Wald-type inference, we discuss the structures of the profile likelihood estimators and their derivatives included in the score function and the Fisher function of the profile likelihood, establishing the consistencies of their estimators.     

Bayesian Approaches to Nonparametric Estimation of Densities on the Unit Interval

This paper investigates nonparametric estimation of density on [0, 1]. The kernel estimator of density on [0, 1] has been found to be sensitive to both bandwidth and kernel. This paper proposes a unified Bayesian framework for choosing both the bandwidth and kernel function. In a simulation study, the Bayesian bandwidth estimator performed better than others, and kernel estimators were sensitive to the choice of the kernel and the shapes of the population densities on [0, 1]. The simulation and empirical results demonstrate that the methods proposed in this paper can improve the way the probability densities on [0, 1] are presently estimated.     

Performance analysis of the retrial queues with finite number of sources and service interruptions

This paper aims at presenting an analytic approach for investigating a single-server retrial queue with finite population of customers where the server is subject to interruptions. A free source may generate a primary call to request service. If the server is free upon arrival, the call starts to be served and the service times are independent, generally distributed random variables. During the service time the source cannot generate a new primary call. After service the source moves into the free state and can generate a new primary call. There is no waiting space in front of the server, and a call who finds the server unavailable upon arrival joins an orbit of unsatisfied customers. The server is subject to interruptions during the service processes. When the server is interrupted, the call being served just before server interruption goes to the retrial orbit and will retry its luck after a random amount of time until it finds the server available. The recovery times of the interrupted server are assumed to be generally distributed. Our analysis extends previous work on this topic and includes the analysis of the arriving customer’s distribution, the busy period, and the waiting time process.     

On the sample breakdown robustness of some nonparametric tests

In this paper, relying on the sample breakdown points, we investigate the sample breakdown properties of some nonparametric tests. It is shown that the sample breakdown points of the sign test asymptotically dominate those of the Wilcoxon test for one–sided hypotheses, However, the different conclusion is derived in the case of testing some shrinking neighborhood hypotheses. The breakdown behaviors of the Kolmogorov test and X²–test are also explored. These studies unify or refine some existing breakdown analyses of tests.     

An augmented data scoring algorithm for maximum likelihood

The expectation-maximization (EM) method facilitates computation of max¬imum likelihood (ML) and maximum penalized likelihood (MPL) solutions. The procedure requires specification of unobservabie complete data which augment the measured or incomplete data. This specification defines a conditional expectation of the complete data log-likelihood function which is computed in the E-stcp. The EM algorithm is most effective when maximizing the iunction Q{0) denned in the F-stnp is easier than maximizing the likelihood function.

The Monte Carlo EM (MCEM) algorithm of Wei & Tanner (1990) was introduced for problems where computation of Q is difficult or intractable. However Monte Carlo can he computationally expensive, e.g. in signal processing applications involving large numbers of parameters. We provide another approach: a modification of thc standard EM algorithm avoiding computation of conditional expectations.     

Model Averaging for Prediction With Fragmentary Data

ABSTRACT

One main challenge for statistical prediction with data from multiple sources is that not all the associated covariate data are available for many sampled subjects. Consequently, we need new statistical methodology to handle this type of “fragmentary data” that has become more and more popular in recent years. In this article, we propose a novel method based on the frequentist model averaging that fits some candidate models using all available covariate data. The weights in model averaging are selected by delete-one cross-validation based on the data from complete cases. The optimality of the selected weights is rigorously proved under some conditions. The finite sample performance of the proposed method is confirmed by simulation studies. An example for personal income prediction based on real data from a leading e-community of wealth management in China is also presented for illustration.     

Semiparametric Smooth Coefficient Stochastic Frontier Model With Panel Data

ABSTRACT

We investigate the semiparametric smooth coefficient stochastic frontier model for panel data in which the distribution of the composite error term is assumed to be of known form but depends on some environmental variables. We propose multi-step estimators for the smooth coefficient functions as well as the parameters of the distribution of the composite error term and obtain their asymptotic properties. The Monte Carlo study demonstrates that the proposed estimators perform well in finite samples. We also consider an application and perform model specification test, construct confidence intervals, and estimate efficiency scores that depend on some environmental variables. The application uses a panel data on 451 large U.S. firms to explore the effects of computerization on productivity. Results show that two popular parametric models used in the stochastic frontier literature are likely to be misspecified. Compared with the parametric estimates, our semiparametric model shows a positive and larger overall effect of computer capital on the productivity. The efficiency levels, however, were not much different among the models. Supplementary materials for this article are available online.     

青岛一套表的实践与经验

 企业统计一套表一直是统计制度方法改革和实践中的焦点问题。本文通过对青岛市统计局企业一套表制度实施情况的案例分析,系统界定了企业一套表的概念和内涵,全面展现了企业一套表的运作过程,客观分析了制约企业一套表实施的主要原因,并提出了在现阶段实施企业统计一套表的条件和要求。     

A Bayesian discovery procedure

Summary.  We discuss a Bayesian discovery procedure for multiple-comparison problems. We show that, under a coherent decision theoretic framework, a loss function combining true positive and false positive counts leads to a decision rule that is based on a threshold of the posterior probability of the alternative. Under a semiparametric model for the data, we show that the Bayes rule can be approximated by the optimal discovery procedure, which was recently introduced by Storey. Improving the approximation leads us to a Bayesian discovery procedure, which exploits the multiple shrinkage in clusters that are implied by the assumed non-parametric model. We compare the Bayesian discovery procedure and the optimal discovery procedure estimates in a simple simulation study and in an assessment of differential gene expression based on microarray data from tumour samples. We extend the setting of the optimal discovery procedure by discussing modifications of the loss function that lead to different single-thresholding statistics. Finally, we provide an application of the previous arguments to dependent (spatial) data.