The Role of Visible Wealth for Deprivation

Social Indicators Research - Motivated by the lack of literature linking actual to perceived relative deprivation, this paper assesses the role of visibility in goods and assets vis-à-vis...     

Sample size re‐estimation incorporating prior information on a nuisance parameter

Prior information is often incorporated informally when planning a clinical trial. Here, we present an approach on how to incorporate prior information, such as data from historical clinical trials, into the nuisance parameter–based sample size re‐estimation in a design with an internal pilot study. We focus on trials with continuous endpoints in which the outcome variance is the nuisance parameter. For planning and analyzing the trial, frequentist methods are considered. Moreover, the external information on the variance is summarized by the Bayesian meta‐analytic‐predictive approach. To incorporate external information into the sample size re‐estimation, we propose to update the meta‐analytic‐predictive prior based on the results of the internal pilot study and to re‐estimate the sample size using an estimator from the posterior. By means of a simulation study, we compare the operating characteristics such as power and sample size distribution of the proposed procedure with the traditional sample size re‐estimation approach that uses the pooled variance estimator. The simulation study shows that, if no prior‐data conflict is present, incorporating external information into the sample size re‐estimation improves the operating characteristics compared to the traditional approach. In the case of a prior‐data conflict, that is, when the variance of the ongoing clinical trial is unequal to the prior location, the performance of the traditional sample size re‐estimation procedure is in general superior, even when the prior information is robustified. When considering to include prior information in sample size re‐estimation, the potential gains should be balanced against the risks.     

Extended pairwise local alignment of wild card DNA/RNA sequences using dynamic programming

Optimal string alignment is used to discover evolutionary relationships or mutations in DNA/RNA or protein sequences. Errors, missing parts or uncertainty in such a sequence can be covered with wild cards, so-called wild bases. This makes an alignment possible even when the data are corrupted or incomplete. The extended pairwise local alignment of wild card DNA/RNA sequences requires additional calculations in the dynamic programming algorithm and necessitates a subsequent best- and worst-case analysis for the wild card positions. In this paper, we propose an algorithm which solves the problem of input data wild cards, offers a highly flexible set of parameters and displays a detailed alignment output and a compact representation of the mutated positions of the alignment. An implementation of the algorithm can be obtained at https://github.com/sysbio-bioinf/swat+ and http://sysbio.uni-ulm.de/?Software:Swat+.     

Modelling human immunodeficiency virus ribonucleic acid levels with finite mixtures for censored longitudinal data

The measurement of human immunodeficiency virus ribonucleic acid levels over time leads to censored longitudinal data. Suitable models for dynamic modelling of these levels need to take this data characteristic into account. If groups of patients with different developments of the levels over time are suspected the model class of finite mixtures of mixed effects models with censored data is required. We describe the model specification and derive the estimation with a suitable expectation-maximization algorithm. We propose a convenient implementation using closed form formulae for the expected mean and variance of the truncated multivariate distribution. Only efficient evaluation of the cumulative multivariate normal distribution function is required. Model selection as well as methods for inference are discussed. The application is demonstrated on the clinical trial ACTG 315 data.     

Correlates of infant pointing frequency in the first year

This study examines the emergence of concurrent correlates of infant pointing frequency with the aim of contributing to its ontogenetic theories. We measured monthly from 8 to 12 months infants' (N = 56) index-finger pointing frequency along with several candidate correlates: (1) family socioeconomic status (SES), (2) mothers' pointing production, and (3) infants' point following to targets in front of and behind them. Results revealed that (1) infants increased their pointing frequency across age, but high-SES infants had a steeper increase, and a higher pointing frequency than low-SES infants from 10 months onward, (2) maternal pointing frequency was not associated with infant pointing frequency at any age, (3) infants' point following abilities to targets behind their visual fields was positively associated with their pointing frequency at 12 months, after pointing had already emerged around 10 months. Findings suggest that family SES impacts infants' pointing development more generally, not just through maternal pointing. The association between pointing and following points to targets behind, but not in front, suggests that a higher level of referential understanding emerges after, and perhaps through the production of pointing.     

The outside and family therapy: A perspective from the relational thinking of Gilles Deleuze

This article was inspired by a reflection on what unfolded with the COVID-19 virus, especially how it brought to light the interconnectedness of individual and collective well-being. This calls for a reassessment of the family therapy approach, which has traditionally focussed on the internal dynamics of the family to explain problems faced by individuals inside the family system without taking into account social, political and historical aspects. This approach, which is referred to in the article as ‘familialism,’ is challenged using the relational philosophy put forward by Gilles Deleuze and Félix Guattari, and a fresh viewpoint is also given from the concept of the ‘outside.’ This outside perspective seeks to prevent the family system from closing in on itself, allowing for the creation of open systems. By doing so, it is argued, it is possible to incorporate different elements of the social, political and historical order in therapeutic practice and prevent underestimating the complexity of the human experience.     

‘Nothing happened’: Legal implications of false denials among abused children

People lie on a frequent basis. However, when a victim of maltreatment lies by denying the abuse, lies can become forensically relevant. We have reviewed the relevant literature on the prevalence and memory consequences of such false denials. The way forensic interviewers proceed in the face of denying children will be shaped by their beliefs about the frequency with which truly abused children deny abuse. We discuss that estimates of the prevalence of false denials among abused children vary but that such false denials do happen. When falsely denying children eventually come forward with their experiences, a second issue lingers: how valid are maltreated children's statements after a false denial? We review the literature indicating that false denials can negatively affect memory for the investigative interview during which the lie was told. Yet, memory for the denied experience itself seems to be mostly preserved, and some research even found potential protective effects of false denials. We conclude that denials should always be handled with care in the court room, since the ground truth usually is not known, but that statements should not be dismissed based solely on previous denials.     

Accepting and Negotiating Service Users' Choices in Mental Health Transition Meetings

Across Western welfare regimes, policies emphasize that service users should have more choices regarding their services. This article examines how service choices are presented, responded to and decided in interactions between service users and professionals in mental health transition meetings. Choice is often associated with consumerist user involvement ideas, but in mental health choice also relates to the democratic user involvement approach and to shared decision making between professionals and service users. The results of the study show that professionals construct service users as consumers by offering service options in choice making sequences, expecting users to make appropriate choices. Service users mostly act like consumers by responding to these choice options. However, the study also demonstrates that the professionals do not always accept the user's first choice but respond to them as non‐preferred. Sometimes, they also suggest choices on behalf of the users. In these ‘non‐accepting’ sequences, choices are negotiated in interaction between the parties, rather than users acting as autonomous choice makers. The sequences are based on two kinds of professional reasoning: first, the professional‐led needs assessment and, second, the structure of the service package that the user is being offered. This negotiation has elements of shared decision making and the ‘logic of care’. But it also has elements of paternalist control which challenge both consumerist and democratic service user involvement and suggests consideration of more collectively oriented service user actions.     

Development and validation of a Citizenship Attributional Style Questionnaire

Attribution theory remains popular in the social sciences and often informs education studies. However, attributional style questionnaires tend to reflect the context-dependent character of the theory and existing measures have been found to have poor psychometric properties. Clearly, both issues need to be carefully considered by researchers prior to them applying any scales that incorporate attributional dimensions. Here we report on the development of a reliable and valid measure that applies an attributional style within the context of citizenship. Two separate studies were conducted to inform the development of the Citizenship Attributional Style Questionnaire (CASQ). The factor loadings of eight positive and eight negative events for the internality and stability dimensions were found to range between .41 and .75. The Cronbach’s alpha reliability of positive and negative events were found to be .79 and .74, respectively. While CASQ is seen to be a reliable and valid measure, the results also indicate broader psychometric properties than many of the instruments currently used in studies with an attributional approach.