Levels of uric acid in erectile dysfunction of different aetiology

Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3–7.5) were significantly higher (p?p?相似文献   

The Relative Contribution of Health Status and Quality of Life Domains in Subjective Health in Old Age

To analyze the influence of different health status dimensions and quality of life (QoL) domains on older adults’ subjective health, and to assess the role that residential satisfaction plays in these relationships. A QoL survey was conducted on a representative sample of the community-dwelling older adult population in Madrid province (Spain). Logistic regression models were applied to studying: the health status dimensions associated with satisfaction with health; the relationship between satisfaction with health and other QoL domains; and, the influence of these domains on satisfaction with life. Sociodemographic and residential characteristics were included in all the models. The determinants of satisfaction with health in the first model were: mobility, usual activities, morbidity, and satisfaction with neighborhood. QoL domains associated with health were: leisure activities, neighborhood, and finances. Satisfaction with life was explained by these three domains, along with age, family and health. In sum, leisure, neighborhood, and finances showed a positive effect on satisfaction with health and with life.     

How does the combination of R&D and types of knowledge matter for patent propensity?

This paper examines whether the combined effects of R&D efforts and the types of knowledge obtained from the invention process determine patent propensity. With this aim, we investigate a unique, manually collected sample of firms and the Spanish and European Patent Offices to analyze how the combination of R&D and knowledge codifiability, observability and simplicity influence the patent decision. Our results contribute to the literature and assist R&D managers by showing that codified knowledge has a positive impact on patent propensity. Furthermore, we find that knowledge observability and simplicity only influence patent propensity when they are combined with internal R&D expenditures.     

Subtle priming of subtraction versus addition: a spill-over effect of math / La inducción sutil de sumar vs. restar: un efecto indirecto de las matemáticas

Abstract

Studies on bias correction have often used blatant inductions to motivate people to reduce the mental impact of perceived biases. In the current research, we test a relatively unexplored, subtle way of inducing bias correction based on the activation of different calculative mindsets. Across two studies, participants were exposed to an advertisement introducing a new consumer product delivered by a credible or non-credible source. Then, as part of an ostensibly unrelated study, participants completed mathematical operations that involved subtracting or adding. Study 1 revealed that when participants were primed with an addition calculative mindset, an expert source elicited more favourable attitudes towards the product than a non-expert source. This pattern illustrates the traditional effect of source credibility on persuasion. In contrast, within the subtraction calculative mindset condition, persuasion was no different between an expert and a non-expert source. These results were obtained exclusively under high thinking conditions (e.g., for participants high in Need for Cognition). This finding can be interpreted as if the effect of source credibility was subtracted from the evaluative judgement. Study 2 replicated this two-way interaction using different materials and inductions. The present research has implications for bias correction, procedural priming, persuasion and beyond.     

‘The Castaways of Life’: A study of organizational remembering within the context of a Chilean Geriatric Hospital

This paper explores the phenomenon of organizational memory within the context of a Chilean Geriatric Hospital that has undergone profound institutional transformations during the last 40 years. The effects of such transformations have reinforced an emphasis on progress at the expense of remembering and integrating the past of the institution as a hospice. The study reveals that this institutional past reverberates in the hospital's working dynamics, which contributes to generating confusion in collective identity, as well as to affect the accomplishment of primary tasks and people's well-being. Access to organizational memory is carried out by the registration of some members' remembering practices about the hospital's past, which are analysed through a hermeneutic method. The study is ethnographic and interpretative, and the recollection of data combines interviews, methods of observation, and the revision of documents.     

Sojourning With the Homogeneous Poisson Process

In this pedagogical article, distributional properties, some surprising, pertaining to the homogeneous Poisson process (HPP), when observed over a possibly random window, are presented. Properties of the gap-time that covered the termination time and the correlations among gap-times of the observed events are obtained. Inference procedures, such as estimation and model validation, based on event occurrence data over the observation window, are also presented. We envision that through the results in this article, a better appreciation of the subtleties involved in the modeling and analysis of recurrent events data will ensue, since the HPP is arguably one of the simplest among recurrent event models. In addition, the use of the theorem of total probability, Bayes’ theorem, the iterated rules of expectation, variance and covariance, and the renewal equation could be illustrative when teaching distribution theory, mathematical statistics, and stochastic processes at both the undergraduate and graduate levels. This article is targeted toward both instructors and students.     

Safe Spaces,Nurturing Places

This article discusses the limited yet important literature on the contributions of historically Black colleges and universities (HBCUs) to students and the profession of social work. The vital role of HBCUs in social work education and their mission to advocate for social and economic justice for disenfranchised populations is also discussed. A case example is then provided to illustrate the safe and nurturing context of HBCUs. Implications for the future are offered.     

Risk of Illness with Salmonella due to Consumption of Raw Unwashed Vegetables Irrigated with Water from the Bogotá River

The Bogotá River receives untreated wastewater from the city of Bogotá and many other towns. Downstream from Bogotá, water from the river is used for irrigation of crops. Concentrations of indicator organisms in the river are high, which is consistent with fecal contamination. To investigate the probability of illness due to exposure to enteric pathogens from the river, specifically Salmonella, we took water samples from the Bogotá River at six sampling locations in an area where untreated water from the river is used for irrigation of lettuce, broccoli, and cabbage. Salmonella concentrations were quantified by direct isolation and qPCR. Concentrations differed, depending on the quantification technique used, ranging between 10^7.7 and 10^9.9 number of copies of gene invA per L and 10^5.3 and 10^8.4 CFU/L, for qPCR and direct isolation, respectively. A quantitative microbial risk assessment model that estimates the daily risk of illness with Salmonella resulting from consuming raw unwashed vegetables irrigated with water from the Bogotá River was constructed using the Salmonella concentration data. The daily probability of illness from eating raw unwashed vegetables ranged between 0.62 and 0.85, 0.64 and 0.86, and 0.64 and 0.85 based on concentrations estimated by qPCR (0.47–0.85, 0.47–0.86, and 0.41–0.85 based on concentrations estimated by direct isolation) for lettuce, cabbage, and broccoli, respectively, which are all above the commonly propounded benchmark of 10^?4 per year. Results obtained in this study highlight the necessity for appropriate wastewater treatment in the region, and emphasize the importance of postharvest practices, such as washing, disinfecting, and cooking.