Conditional inference under simultaneous stochastic ordering constraints

Testing for stochastic ordering is of considerable importance when increasing does of a treatment are being compared, but in applications involving multivariate responses has received much less attention. We propose a permutation test for testing against multivariate stochastic ordering. This test is distribution-free and no assumption is made about the dependence relations among variables. A comparative simulation study shows that the proposed solution exhibits a good overall performance when compared with existing tests that can be used for the same problem.     

HOUSING FINANCE AND MONETARY POLICY

We document three facts concerning how the structure of housing finance affects the monetary transmission mechanism: first, the characteristics of residential mortgage markets differ markedly across industrialized countries; second, the impact of monetary policy shocks to residential investment and house prices is significantly stronger in those countries with larger flexibility/development of mortgage markets; third, the transmission to consumption is stronger only in those countries where mortgage equity release is common and mortgage contracts are predominantly of the variable‐rate type. We then build a two‐sector DSGE model with financial constraints to rationalize those facts.     

Central hypogonadism due to a giant, “silent” FSH-secreting,atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG)

We present a case report of an atypical giant pituitary adenoma secreting follicle-stimulating hormone (FSH). A 55-year-old patient presented for erectile dysfunction, loss of libido and fatigue. The biochemical evaluation showed very high FSH serum levels in the presence of central hypogonadism. Neither testicular enlargement nor increased sperm count was observed, thus a secretion of FSH with reduced biological activity was supposed. The histological examination after neuro-surgery showed an atypical pituitary adenoma with FSH-positive cells. Hypogonadism persisted and semen analyses impaired until azoospermia in conjunction with the reduction in FSH levels suggesting that, at least in part, this gonadotropin should be biologically active. Thus, we hypothesized a concomitant primary testicular insufficiency. The patient underwent short-term treatment trials with low doses of either recombinant luteinizing hormone (LH) or human chorionic gonadotropin (hCG) in three consecutive treatment schemes, showing an equal efficacy in stimulating testosterone (T) increase. This is the first case of atypical, giant FSH-secreting pituitary adenoma with high FSH serum levels without signs of testicular hyperstimulation, in presence of hypogonadism with plausible combined primary and secondary etiology. Hypophysectomized patients may represent a good model to assess both pharmacodynamics and effective dose of LH and hCG in the male.     

A Permutation and Combination-Based Solution on the Ranking of Multivariate Populations in the Case of Ordered Categorical Responses with Application to the Evaluation of the Indoor Environment

This article deals with the problem of classifying and ranking several multivariate populations of interests using the permutation and combination approach providing also an inferential validity of the procedure. The need to define an appropriate classification of populations, i.e., products, services, teaching courses, degree programs, and so on, is very common within many areas of applied research. Many times the populations of interest are multivariate in nature meaning that many aspects of that populations can be simultaneously observed on the same unit/subject. From a statistical point of view, when the response variable of interest is multivariate in nature, the problem may become quite difficult to cope with especially in case of ordered categorical responses, due to the large dimensionality of the parametric space. Nonparametric inference based on the NPC methodology however, allows us to overcome these limitations, without the need of referring to assume any specified random distribution.     

Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG)

Insulin-like growth factor 1 (IGF-1) signaling modulation has been associated with increased lifespan in model organisms, while high levels of circulating interleukin-6 (IL-6) are a marker of disability and mortality. In the prospective, population-based "Treviso Longeva"--TRELONG Study from Italy (n = 668, age range 70-105.5 years at baseline, followed for seven years) we investigated the effects of survival on the IGF-1 receptor (IGF-1R) gene polymorphism rs2229765, the IL-6 gene promoter polymorphism rs1800795, and plasma concentrations of IGF-1 and IL-6, alone or in combination. We found a sex-dependent effect for the IGF-1R rs2229765 polymorphism, as male carriers of the homozygous A/A genotype survived longer, while the IL-6 rs1800795 genotype did not influence overall or sex-specific longevity. Higher IL-6 levels were more detrimental for survival among males than females, while IGF-1 had no dose-response effect. These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females.     

Exact inference for multivariate ordered alternatives

In this paper we discuss three types of ordered alternatives ordered location, stochastic ordering and quadrant dependence. We prove that quadrant dependence is the more general among the three. Then we consider a conditional tests for the equality of c distributions against quadrant dependence in a multivariate setup. An exact simultaneous testing procedure based on dependent conditional tests is presented. Two applications to real data are also given.