Nonlinear mixed effects modelling for estimation of steady state attainment

Assessment of the time needed to attain steady state is a key pharmacokinetic objective during drug development. Traditional approaches for assessing steady state include ANOVA‐based methods for comparing mean plasma concentration values from each sampling day, with either a difference or equivalence test. However, hypothesis‐testing approaches are ill suited for assessment of steady state. This paper presents a nonlinear mixed effects modelling approach for estimation of steady state attainment, based on fitting a simple nonlinear mixed model to observed trough plasma concentrations. The simple nonlinear mixed model is developed and proposed for use under certain pharmacokinetic assumptions. The nonlinear mixed modelling estimation approach is described and illustrated by application to trough data from a multiple dose trial in healthy subjects. The performance of the nonlinear mixed modelling approach is compared to ANOVA‐based approaches by means of simulation techniques. Copyright © 2005 John Wiley & Sons, Ltd.     

Reflexive audiovisual methodology: The emergence of “minority practices” among pluriactive stock farmers

This paper proposes a new way for sociology, through both methodology and theory, to understand the reality of social groups and their “minority practices.” It is based on an experiment that concerns a very specific category of agriculturalists called “pluriactive” stock farmers. These stock farmers, who engage in raising livestock part-time alongside another full-time job, form a minority category within the agricultural profession.We address the question of how to analyze and represent the practices of this kind of “social” group or category through participatory filmmaking. Our research shows that beyond the collaborative production and screening of the film done in close cooperation with the stock farmers themselves, a second unexpected dynamic emerged around the sequences that were cut in the final editing round. These cut sequences reveal hesitations and disagreements among the breeders about their own practices in relation to their work and to animal welfare. These hesitations are not considered weaknesses, but rather as proof of the emergence of this group of stock farmers as “practitioners”. In the realm of intervention research, the participatory film-making process is attractive because it enables the farmers to raise new questions on their own, discuss them, and eventually resolve them, while also encouraging the researchers to identify the conditions that must be met in order to achieve this fragile linkage. This process and its outcomes force us to revisit the theoretical question of what constitutes a pragmatic definition of a “practice.”     

Predictors of Capacity-Building Needs Among Nongovernmental Organizations in Sub-Saharan Africa

Nongovernmental organizations (NGOs) play important roles in social development in the Global South. However, little evidence exists concerning NGOs’ capacity-building needs. We sought to understand organizational and network factors that explain capacity-building needs. Using an online survey of 282 NGOs in Ghana, Kenya, and Nigeria, we found high levels of capacity-building need, particularly concerning resource development. Using multivariate analyses, we found greater staff size predicted less overall capacity-building need based on a 15-item index (α = .88). Examining individual capacities, receiving at least half of funding from international sources and prior capacity-building assistance were consistent predictors of lower odds of capacity-building need.     

A maximum likelihood estimator for left-truncated lifetimes based on probabilistic prior information about time of occurrence

In forestry, many processes of interest are binary and they can be modeled using lifetime analysis. However, available data are often incomplete, being interval- and right-censored as well as left-truncated, which may lead to biased parameter estimates. While censoring can be easily considered in lifetime analysis, left truncation is more complicated when individual age at selection is unknown. In this study, we designed and tested a maximum likelihood estimator that deals with left truncation by taking advantage of prior knowledge about the time when the individuals enter the experiment. Whenever a model is available for predicting the time of selection, the distribution of the delayed entries can be obtained using Bayes' theorem. It is then possible to marginalize the likelihood function over the distribution of the delayed entries in the experiment to assess the joint distribution of time of selection and time to event. This estimator was tested with continuous and discrete Gompertz-distributed lifetimes. It was then compared with two other estimators: a standard one in which left truncation was not considered and a second estimator that implemented an analytical correction. Our new estimator yielded unbiased parameter estimates with empirical coverage of confidence intervals close to their nominal value. The standard estimator leaded to an overestimation of the long-term probability of survival.     

Framing European integration in mediated public spheres: an increasing nationalization and contestation of European issues in party political communication?

This article proposes a claims-making analysis of party political communication over Europe in mediated public spheres in France, Ireland, the UK and Spain between 1993 and 2006. It demonstrates that office-seeking parties and especially the representatives of the executive power generally dominate Europeanized debates. In contrast, peripheral parties and other party actors such as party MPs and extra-parliamentary politicians face significant difficulties in obtaining visibility and resonance for their Europeanized frames. The empirical and longitudinal analysis also shows the prevalence of claims directed towards the EU level and of nationalized debates over Europe. Overall, even though critical engagements with Europe have progressed over time, the domination of mainstream parties and party actors in framing European integration and the pro-European consensus between office-seeking parties nevertheless limit the potential for contestation on European matters.     

Determinants of work-family balance satisfaction during the pandemic: Insights from Québec

The first wave of the COVID pandemic was the most challenging for employed parents, and more specifically for women. In Québec, research has shown a deterioration in the psychological health of parents in the early weeks of the pandemic. In this research, we investigate how Québec parents who remained employed during the lockdown in 2020 perceived their work-family balance in the stressful context of new earning and caregiving constraints, drawing on survey data collected in May 2020. Our approach integrates insights from psychological, managerial and sociological literatures. We find that most parents who remained employed found their work-family balance “easy” in the first months of the pandemic, but women felt less satisfied with their work-family balance than men as well as those whose employers were less understanding and supportive, and those whose workloads increased. The implications of these results are discussed in the light of previous studies on work-family intersections, to show that gender continues to matter when family members are faced with extraordinary circumstances such as the closing of childcare and schools, even in the egalitarian context of Québec, where fathers are perceived as legitimate caregivers.     

Family Well-Being During the COVID-19 Pandemic: The Risks of Financial Insecurity and Coping

During the COVID-19 pandemic, families have experienced unprecedented financial and social disruptions. We studied the impact of preexisting psychosocial factors and pandemic-related financial and social disruptions in relation to family well-being among N = 4091 adolescents and parents during early summer 2020, participating in the Adolescent Brain Cognitive Development^SM Study. Poorer family well-being was linked to prepandemic psychosocial and financial adversity and was associated with pandemic-related material hardship and social disruptions to routines. Parental alcohol use increased risk for worsening of family relationships, while a greater endorsement of coping strategies was mainly associated with overall better family well-being. Financial and mental health support may be critical for family well-being during and after a widespread crisis, such as the COVID-19 pandemic.