Spatial Cluster Detection for Longitudinal Outcomes Using Administrative Regions

This article proposes a new spatial cluster detection method for longitudinal outcomes that detects neighborhoods and regions with elevated rates of disease while controlling for individual level confounders. The proposed method, CumResPerm, utilizes cumulative geographic residuals through a permutation test to detect potential clusters which are defined as sets of administrative regions, such as a town or group of administrative regions. Previous cluster detection methods are not able to incorporate individual level data including covariate adjustment, while still being able to define potential clusters using informative neighborhood or town boundaries. Often, it is of interest to detect such spatial clusters because individuals residing in a town may have similar environmental exposures or socioeconomic backgrounds due to administrative reasons, such as zoning laws. Therefore, these boundaries can be very informative and more relevant than arbitrary clusters such as the standard circle or square. Application of the CumResPerm method will be illustrated by the Home Allergens and Asthma prospective cohort study analyzing the relationship between area or neighborhood residence and repeated measured outcome, occurrence of wheeze in the last six months, while taking into account mobile locations.     

Bonferroni-type Plug-in Procedure Controlling Generalized Familywise Error Rate

Consider the multiple hypotheses testing problem controlling the generalized familywise error rate k-FWER, the probability of at least k false rejections. We propose a plug-in procedure based on the estimation of the number of true null hypotheses. Under the independence assumption of the p-values corresponding to the true null hypotheses, we first introduce the least favorable configuration (LFC) of k-FWER for Bonferroni-type plug-in procedure, then we construct a plug-in k-FWER-controlled procedure based on LFC. For dependent p-values, we establish the asymptotic k-FWER control under some mild conditions. Simulation studies suggest great improvement over generalized Bonferroni test and generalized Holm test.     

The adaptive calibration of testing p-values

Abstract

In statistical hypothesis testing, a p-value is expected to be distributed as the uniform distribution on the interval (0, 1) under the null hypothesis. However, some p-values, such as the generalized p-value and the posterior predictive p-value, cannot be assured of this property. In this paper, we propose an adaptive p-value calibration approach, and show that the calibrated p-value is asymptotically distributed as the uniform distribution. For Behrens–Fisher problem and goodness-of-fit test under a normal model, the calibrated p-values are constructed and their behavior is evaluated numerically. Simulations show that the calibrated p-values are superior than original ones.     

Estimation on semi-functional linear errors-in-variables models

Abstract

Semi-functional linear regression models are important in practice. In this paper, their estimation is discussed when function-valued and real-valued random variables are all measured with additive error. By means of functional principal component analysis and kernel smoothing techniques, the estimators of the slope function and the non parametric component are obtained. To account for errors in variables, deconvolution is involved in the construction of a new class of kernel estimators. The convergence rates of the estimators of the unknown slope function and non parametric component are established under suitable norm and conditions. Simulation studies are conducted to illustrate the finite sample performance of our method.     

On Redundancy Allocation to Series and Parallel Systems of Two Components

Abstract

For two components and one standby redundancy, we develop a characterization on the hazard rate order and the reversed hazard rate order of the redundant system lifetime in the context of mutually independent components lifetimes. Also, the likelihood ratio order is derived on the lifetime of the series system with two components lifetimes and two matched active redundancies lifetimes both following the proportional hazard model.     

A multiple-case deletion approach for detecting influential points in high-dimensional regression

ABSTRACT

In high-dimensional regression, the presence of influential observations may lead to inaccurate analysis results so that it is a prime and important issue to detect these unusual points before statistical regression analysis. Most of the traditional approaches are, however, based on single-case diagnostics, and they may fail due to the presence of multiple influential observations that suffer from masking effects. In this paper, an adaptive multiple-case deletion approach is proposed for detecting multiple influential observations in the presence of masking effects in high-dimensional regression. The procedure contains two stages. Firstly, we propose a multiple-case deletion technique, and obtain an approximate clean subset of the data that is presumably free of influential observations. To enhance efficiency, in the second stage, we refine the detection rule. Monte Carlo simulation studies and a real-life data analysis investigate the effective performance of the proposed procedure.     

Random sampling from the watson distribution

An envelope-rejection method is used to generate random variates from the Watson distribution. The method is compact and is competitive with, if not superior to, the existing sampling algorithms. For the girdle form of the Watson distribution, a faster algorithm is proposed. As a result, Johnson's sampling algorithm for the Bingham distribution is improved.     

Likelihood Ratio Order of m-Spacings in Multiple-Outlier Models

This article deals with the multiple-outlier exponential model. The likelihood ratio order between m-spacings of the combined sample is developed, some results extend the conclusions on simple spacings in Wen et al. (2007 Wen , S. , Lu , Q. , Hu , T. ( 2007 ). Likelihood ratio order of spacings of heterogeneous exponential random variables . J. Multivariate Anal. 98 : 743 – 756 .[Crossref], [Web of Science ®] , [Google Scholar]).     

Testing for the Equality of Two Autoregressive Functions Using Quasi-Residuals

This article discusses the problem of testing the equality of two nonparametric autoregressive functions against one-sided alternatives. The heteroscedastic errors and stationary densities of the two independent strong mixing strictly stationary time series can be possibly different. The article adapts the idea of using sum of quasi-residuals to construct the test and derives its asymptotic null distributions. The article also shows that the test is consistent for general alternatives and obtains its limiting distributions under a sequence of local alternatives. Then a Monte Carlo simulation is conducted to study the finite sample level and power behavior of these tests at some alternatives. We also compare the test to an existing lag matched test theoretically and by Monte Carlo experiments.