Analysis of microtubule dynamics using growth curve models

Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics.     

马克思主义中国化过程的多维透视

马克思主义中国化是过程与结果的统一,过程产生结果,结果来自过程.立足过程本身,多维透视马克思主义中国化过程,探索其中文化选择、思想斗争、实践运用、理论创新、问题解决等不同方面的历史运动过程,无疑有助于深入认识马克思主义中国化的理论本质和实践逻辑.     

A one- sample test based on subsamples medians

Nonparametric test statistics are constructed by considering the medians in subsamples of appropriate size taken -from n independent observations. These tests are shown to be sensitive to both heavy and moderate tailed distributions.     

Response predictions in regressions on panel data

In this paper we consider the problem of obtaining best linear unbiased estimators of individual response coefficients in a Random Coefficient Linear Regression (RCR} Model, comparing alternative estimators for these response vectors through a simulation study. We also provide an empirical example that illustrates the estimation procedure proposed here.     

On the use of the scholz-sievers method for dlstribution-free inference about the difference in slopes of two regression lines

A simple adaptation of a distribution-free method due to Scholz (1978) and Sievers (1978) for inference in a single regression setting is proposed for inference about the difference in slopes of two regression lines. We assume that the data are obtained from a designed experiment with common regression constants. A comparison of the proposed method to its competitors-one due to Hollander and the other due to Rao and Gore-indicates superiority of the new method.     

Social Activity,School-related Activity,and Anti–substance Use: Media Messages on Adolescent Tobacco and Alcohol Use

In this article, we present the effects of three hypothesized protective factors—social activities, school-related activities, and anti–substance use media messages—on adolescent tobacco and alcohol use. Data were drawn from the “Monitoring the Future” research project, which was conducted by the Institute for Social Research at the University of Michigan. The sample included 2,551 twelfth-grade students. The results of the structural equation model showed that exposure to media anti-drug messages had an indirect negative effect on tobacco and alcohol use through school-related activity and social activity. The results suggest that comprehensive ecological interventions encompassing media, family, and school can increase the preventive effects of adolescent's substance use.     

Use of prior information for estimating the variance components

The MINQUE and its modifications are considered for estimating the variances of the balanced one-way random effects model. The effects of the a priori values on the estimators of the variances are examined in detail. The Mean Square Errors of the estimators are compared for variations in the prior values of the unknown variances.     

Policy Imperatives for the International Economy and for Financial Markets in the Emerging World Order

The world economy today is swept by unprecedented rates of change, complexity, interconnectedness, and uncertainty. For the first time since the 1930s, issues of the international economy and financial markets are playing a pivotal role in discussions of foreign and domestic policy. However, even as the revolutionary trends in the international economy and in world finance are in the offing, it is important to realize that the problems of mankind are primarily economic and social, not financial or political. While the trends towards liberalization of economic policies and integration of financial markets might seem to point toward the ultimate triumph of the magic of the market and free enterprise, a little reflection will reveal a number of undercurrents, dilemmas, and difficult choices waiting to be resolved. This article identifies the structural and human dimensions of these challenges in the form of thirteen Policy Imperatives aimed at the creation of modified versions of financial markets to make them more humane and less vulnerable to failure.