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921.
Two testable propositions suggested in the Davis and Moore functional theory of stratification are examined: the effect of scarcity on rewards and the effect of higher rewards on mobility. Data on the occupation of public school teaching for the period 1930 to 1971 were analyzed and compared with other wage and salary workers during those years. The proposition that scarcity increases rewards is rejected by these data, because higher incomes occur during periods (1) when there was less scarcity of teachers and (2) when employers discriminated against qualified married females in their hiring practices. The proposition that an increase in income advantage increases the movement of more qualified personnel into those positions found support, but for reasons more consistent with a conflict than a functional explanation. This research demonstrates the importance of economic incentives in attracting personnel but more importantly it documents how “political” groupings can regulate market forces. 相似文献
922.
For the past six years the State of Alaska has engaged in a unique program in which annual direct cash distributions have been made to the populace. These distributions represent in a sense dividend payments made to citizens on their individual shares of Alaska's mineral wealth. This paper provides a historic perspective of the Alaska dividend distribution program and examines actual distributions to determine whether they are consistent with utility maximization. We found that either a dramatic change in preferences took place over the past six years or that distributions were inconsistent with intertmporal utility maximization. 相似文献
923.
Integrating dose estimation into a decision‐making framework for model‐based drug development 下载免费PDF全文
James Dunyak Patrick Mitchell Bengt Hamrén Gabriel Helmlinger James Matcham Donald Stanski Nidal Al‐Huniti 《Pharmaceutical statistics》2018,17(2):155-168
Model‐informed drug discovery and development offers the promise of more efficient clinical development, with increased productivity and reduced cost through scientific decision making and risk management. Go/no‐go development decisions in the pharmaceutical industry are often driven by effect size estimates, with the goal of meeting commercially generated target profiles. Sufficient efficacy is critical for eventual success, but the decision to advance development phase is also dependent on adequate knowledge of appropriate dose and dose‐response. Doses which are too high or low pose risk of clinical or commercial failure. This paper addresses this issue and continues the evolution of formal decision frameworks in drug development. Here, we consider the integration of both efficacy and dose‐response estimation accuracy into the go/no‐go decision process, using a model‐based approach. Using prespecified target and lower reference values associated with both efficacy and dose accuracy, we build a decision framework to more completely characterize development risk. Given the limited knowledge of dose response in early development, our approach incorporates a set of dose‐response models and uses model averaging. The approach and its operating characteristics are illustrated through simulation. Finally, we demonstrate the decision approach on a post hoc analysis of the phase 2 data for naloxegol (a drug approved for opioid‐induced constipation). 相似文献
924.
Theoreticians have used the concepts of lifestyle and routine activities to account for the occurrence of personal crime victimization. Research has not usually used direct measures of these concepts, however, instead relying on demographic variables such as age and sex as proxy indicators. This paper analyzes the relationship of various job activities (delivering passengers or goods, traveling out of town, dealing face-to-face with customers, and working irregular hours) to the risk of violent and theft-damage personal crime victimization, and to the risk of such victimization at work. Logistic regression models show that delivery of passengers or goods and dealing with the public are robustly associated with violent victimization. None of the four job activities are consistently associated with theft-damage victimization risk. The results illustrate the importance of using direct measures of life-style or routine activities to examine exposure to the risk of victimization. The findings also suggest the need to elaborate further the notion of exposure, and to develop a second generation of victimization theory. 相似文献
925.
Northern Ireland has been and continues to be deeply divided on the basis of religion. This paper examines and compares contemporary fertility in the two communities given the sharp declines that have occurred in recent decades. The data are drawn from the Northern Ireland Longitudinal Study and cover 108,000 women aged 16–44 in the period 1997–2007. A logit analysis of births in the period is undertaken based on individual demographic data and also the characteristics of the locality in which the woman is resident. The effect of religion is measured by its individual marginal effect averaged over the total sample, over time and by the age of the woman. The estimated average marginal effect is 4 % of the probability of a woman having a birth over the entire period. The effect peaks when the woman is between 29 and 30 years and is stable over time. When the fertility behaviour of each religious group is compared separately with those women that came from the same background but had lost their religion, it is found to differ substantially. Thus, community background is rejected as a possible explanation of the difference in fertility between declared Catholics and Protestants. Although the fertility rates of former Catholics and Protestants appear to be converging, the size of these groups is relatively small. There is no evidence to suggest that the small but distinct difference in the fertility rates of the two religious communities is likely to change in the immediate future. 相似文献
926.
This article reports two studies that investigated the ways in which children use gender and ethnicity for making judgments about food choice. In Study 1, White and Asian 5- to 10-year-olds (M = 7.37) were asked to rate how much they and others would like novel non-stereotyped foods. White children inferred that girls and White others would like the foods more than boys and Asian others would. An 'ethnocentric' pattern was found where children inferred that ethnic in-group others' food-liking would be more similar to their own compared with ethnic out-group others. These patterns were replicated with adults. In Study 2, a larger range of foods was used to assess White, Black, and Asian 3- to 8-year-olds (M = 5.63), followed by gender and ethnic categorization and constancy tasks. Children from five to six years used ethnicity-based reasoning, which was influenced by their ability to categorize themselves and others by ethnicity. The role of social categories in food choice is discussed in the light of theories and research in category-based reasoning. 相似文献
927.
Patrick McNamee 《Long Range Planning》1984,17(3):98-114
The objective of this paper is to explore how selected matrix displays can aid strategic management. Three types of matrix— the Directional Policy, the Hofer and the Patel and Younger— are considered and the particular contribution that each can make is examined. Each type makes a particular contribution and which type, or types, should be used by strategic planners should be a function of the objectives of the exercise and the data available. 相似文献
928.
Varjonen M Santtila P Höglund M Jern P Johansson A Wager I Witting K Algars M Sandnabba NK 《Journal of sex research》2007,44(4):359-369
The Sexual Inhibition and Sexual Excitation Scales (SIS/SES) measure the propensity for sexual inhibition and excitation in men. According to the theoretical model underlying the SIS/SES, sexual response and associated behavior depend on dual control mechanisms in the brain involving the balance of excitatory and inhibitory systems which impinge on sexual response. Previous research with the SIS/SES has indicated one higher-order excitatory factor and two higher-order inhibitory factors affecting sexual response. The present study analyzed the item structure and the psychometric properties of the instrument in a population based sample of Finnish male twins (N = 1,289), and, including 37 out of 45 items of the original scales, estimated the heritability of and the environmental influences on the excitatory and inhibitory mechanisms. The twin correlations and the structural equation modeling suggested modest heritability for both inhibitory mechanisms. Sexual excitation, in contrast, was not influenced by genetic effects and similarities between twins for this mechanism seemed to be caused by the common environment of the twins. 相似文献
929.
This is the first multisite, prospective study of behavioral and mental health disorders of youth in residential treatment centers (RTC) and therapeutic foster care (TFC), and the first study to compare the two. This study addressed two questions in a sample of 22 agencies in 13 states: (1) how prevalent were emotional and behavioral disorders in the youth admitted to RTCs and TFC?, and (2) were the youth in RTCs significantly more likely to be disturbed than youth served in TFCs? Data were drawn from the Time 1 phase of the longitudinal national "Odyssey Project" developed by the Child Welfare League of America (1995). Measures included an extensive child and family characteristics form (CFC) and the Child Behavior Checklist (CBCL). The results revealed extremely high levels of behavioral and mental health disorders in the sample as a whole, well above the norms for a non-child welfare population. The prevalence of disorder in the RTC population was substantially greater than in the TFC population. 相似文献
930.
Ladouceur R Sylvain C Gosselin P 《Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming》2007,23(1):85-94
Few self-exclusion programs have been evaluated and their long-term impact remains unknown. This study has two main goals:
(1) to assess changes in gambling behaviour and gambling problems for self-excluded patrons, and (2) to follow self-excluded
gamblers for a two-year period (during and after the self-exclusion period). Individuals who excluded themselves (N = 161 at the initial stage) participated in telephone interviews after signing the self-exclusion agreement and were followed
at 6, 12, 18 and 24-months. Results show that according to the DSM-IV, 73.1% of the participants were pathological gamblers.
The self-exclusion program has many positive effects. During the follow-ups, the urge to gamble was significantly reduced
while the perception of control increased significantly for all participants. The intensity of negative consequences for gambling
was significantly reduced for daily activities, social life, work, and mood. The DSM score was significantly reduced over time. This reduction also took place between the baseline and the 6-month
follow-up. The clinical implications of the results are discussed in relation to the effectiveness of the program. Suggestions
are provided in order to increase compliance of self-excluded patrons. 相似文献