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191.
Paul S. Appelbaum 《Accountability in research》2013,20(2-4):265-276
Concern about the participation of incompetent subjects in psychiatric research has grown in the last several years. In response, the National Bioethics Advisory Commission (NBAC) recommended in its recent report that all investigations involving persons with mental disorders that may be associated with cognitive impairment that may pose greater than minimal risk to subjects utilize independent assessors to verify the capacities of subjects prior to entry into the study. This recommendation poses several problems for the conduct of research and the protection of research subjects. First, it fails to target that group of subjects most likely to be at risk for incapacity. Second, it focuses on too broad a range of research projects, many of which pose little risk to participants. The substantial costs of this approach are therefore not likely to be outweighed by concomitant benefits. In place of the NBAC recommendation, the author proposes a more flexible system of capacity assessment, designed to balance the costs with a greater likelihood of achieving meaningful protection for research subjects with mental disorders. 相似文献
192.
Paul D. Lepore 《Accountability in research》2013,20(2):101-105
In the Federal Register of December 22, 1978, the Food and Drug Administration (FDA) published regulations which described Good Laboratory Practice for safety tests conducted on regulated products (Anonymous, 1978). The regulations, popularly known as GLPs, have become universally recognized as the basic criteria for the conduct of a valid safety test and for assuring the quality and integrity of the collected data. Along with the publication of the GLPs, FDA instituted a vigorous program of inspection of toxicology laboratories to determine the degree of adherence to the regulations. In 1984, based on inspectional findings which revealed that a large majority of toxicology laboratories were adhering to the GLPs, FDA published a proposal intended to reduce the burden of compliance with the regulations (Anonymous, 1984). The proposal outlined major changes in the provisions on quality assurance, protocol preparation, test and control article characterization, and retention of specimens and samples. The final order based on the proposal was published in the federal register of September 4, 1987 (Anonymous). The purpose of this communication is to describe the procedures used by FDA to develop the final order, to discuss certain major issues that arose during its development, and to answer several questions that have arisen subsequently. 相似文献
193.
In an analysis of 25 semi‐structured interviews with highly educated asylum seekers and refugees in The Netherlands, we have traced their learning strategies, the stability of their educational and professional career patterns between home and host country, the calculative nature of the choices made in this context and the influence of family ties. In the analysis, we explored the fit of two competitive theoretical perspectives: Pierre Bourdieu’s field theory and the biographical approach. The respondents showed a surprising degree of stability with regard to their career patterns, calculation with regard to educational choices was weak and there was a strong influence of family ties. From these results, it would seem that the field theory shows a better fit than the biographical approach. Longitudinal research is needed to test this hypothesis in more rigorous ways. Moreover, the research has pointed at omissions and ambivalences with regard to the relationship of changes in field structures and habitus change, the relative relevance of mental and material conditions for human agency in the work of Bourdieu. In the analysis, several variables specifically related to the situation of refugees and asylum seekers could be traced that additionally explain the findings. 相似文献
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“Hookups”: Characteristics and correlates of college students' spontaneous and anonymous sexual experiences 总被引:1,自引:0,他引:1
This study focused on a specific risky practice common among contemporary college students: the hookup. Hookups are defined as a sexual encounter which may or may not include sexual intercourse, usually occurring on only one occasion between two people who are strangers or brief acquaintances. The aim of this study was to determine the relative importance of a variety of social and psychological predictors in understanding differences among undergraduate students who had never hooked up, those who had hooked up without sexual intercourse, and those who had hooked up with sexual intercourse. Analyses revealed that, as predicted, social, individual, and relational psychological variables helped to explain the variance among college students' varied hookup experiences. By examining the full range of sexual involvement characteristic of the casual sexual phenomenon of hooking up within a multivariate model, we were able to achieve a more differentiated understanding of college students' casual sexual experimentation. 相似文献
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198.
Jeffrey L. Andrews Paul D. McNicholas 《Journal of statistical planning and inference》2011,141(4):1479-1486
A novel family of mixture models is introduced based on modified t-factor analyzers. Modified factor analyzers were recently introduced within the Gaussian context and our work presents a more flexible and robust alternative. We introduce a family of mixtures of modified t-factor analyzers that uses this generalized version of the factor analysis covariance structure. We apply this family within three paradigms: model-based clustering; model-based classification; and model-based discriminant analysis. In addition, we apply the recently published Gaussian analogue to this family under the model-based classification and discriminant analysis paradigms for the first time. Parameter estimation is carried out within the alternating expectation-conditional maximization framework and the Bayesian information criterion is used for model selection. Two real data sets are used to compare our approach to other popular model-based approaches; in these comparisons, the chosen mixtures of modified t-factor analyzers model performs favourably. We conclude with a summary and suggestions for future work. 相似文献
199.
We consider the square contingency tables which arise when the same method of classification is applied twice. The hypothesis of marginal homogeneity is then relevant! and can be tested by various methods Models are discussed which contain marginal homogeneity as a special case. They include a class based on univariate and bivariate Dirichlet distributions. The question of ordered categories is briefly discussed. Applications are made to data on unaided distance vision. 相似文献
200.
This paper examines the impact of immigrant status on home ownership in Australia. It shows that the rate of home ownership for most groups of immigrants is comparable to that of the Australian born. As expected, recently arrived immigrants have relatively low probabilities of owning their own home. These results hold for both analyses pooled across movers and non‐movers, and for analyses restricted to those, both immigrants and the native born, who moved residence in the previous five years. A decomposition of the estimated coefficients of the model of tenure choice is developed. This is shown to enhance understanding of variations in rates of home ownership across birthplace groups. 相似文献