Integrating ethical enquiry and health technology assessment: limits and opportunities for efficiency and equity

This paper aims at discussing some contributions, limitations and opportunities that efficiency and equity studies could make to form a better understanding of ethical issues involved in health technology assessment (HTA). Prenatal detection of Down syndrome is used as a case study for further discussions regarding efficiency and equity, as well as other ethical principles including beneficence, non-maleficence and autonomy. The development and use of adequate methods and the need for context appraisal are two imperative issues in this field of knowledge. The analysis of ethical implications in HTA should account for both. Economic evaluation methodologies have great potential in the assessment of some key ethical principles such as efficiency and equity but are of limited use concerning other fundamental principles. Social and individual values play a prominent role in this respect.     

Measuring non-linear dependence for two random variables distributed along a curve

We propose new dependence measures for two real random variables not necessarily linearly related. Covariance and linear correlation are expressed in terms of principal components and are generalized for variables distributed along a curve. Properties of these measures are discussed. The new measures are estimated using principal curves and are computed for simulated and real data sets. Finally, we present several statistical applications for the new dependence measures.     

Link-tracing sampling with an initial sequential sample of sites: Estimating the size of a hidden human population

We proposed a modification to the variant of link-tracing sampling suggested by Félix-Medina and Thompson [M.H. Félix-Medina, S.K. Thompson, Combining cluster sampling and link-tracing sampling to estimate the size of hidden populations, Journal of Official Statistics 20 (2004) 19–38] that allows the researcher to have certain control of the final sample size, precision of the estimates or other characteristics of the sample that the researcher is interested in controlling. We achieve this goal by selecting an initial sequential sample of sites instead of an initial simple random sample of sites as those authors suggested. We estimate the population size by means of the maximum likelihood estimators suggested by the above-mentioned authors or by the Bayesian estimators proposed by Félix-Medina and Monjardin [M.H. Félix-Medina, P.E. Monjardin, Combining link-tracing sampling and cluster sampling to estimate the size of hidden populations: A Bayesian-assisted approach, Survey Methodology 32 (2006) 187–195]. Variances are estimated by means of jackknife and bootstrap estimators as well as by the delta estimators proposed in the two above-mentioned papers. Interval estimates of the population size are obtained by means of Wald and bootstrap confidence intervals. The results of an exploratory simulation study indicate good performance of the proposed sampling strategy.     

Nenparametric Two-Group Classification: Concepts and a SAS-Based Software Package

This article introduces BestClass, a set of SAS macros, available in the mainframe and workstation environment, designed for solving two-group classification problems using a class of recently developed nonparametric classification methods. The criteria used to estimate the classification function are based on either minimizing a function of the absolute deviations from the surface which separates the groups, or directly minimizing a function of the number of misclassified entities in the training sample. The solution techniques used by BestClass to estimate the classification rule use the mathematical programming routines of the SAS/OR software. Recently, a number of research studies have reported that under certain data conditions this class of classification methods can provide more accurate classification results than existing methods, such as Fisher's linear discriminant function and logistic regression. However, these robust classification methods have not yet been implemented in the major statistical packages, and hence are beyond the reach of those statistical analysts who are unfamiliar with mathematical programming techniques. We use a limited simulation experiment and an example to compare and contrast properties of the methods included in Best-Class with existing parametric and nonparametric methods. We believe that BestClass contributes significantly to the field of nonparametric classification analysis, in that it provides the statistical community with convenient access to this recently developed class of methods. BestClass is available from the authors.     

Statistics in Latin America

Statistics is a relatively new discipline in Latin America. At present only sparse information is available about the state of the statistical profession in Latin America. We present and summarize the available information about the job market; training, education, and research; professional societies and their activities; and so forth. We also share our hopes, concerns, and suggestions for the future.     

Generalized Jackknife-Based Estimators for Univariate Extreme-Value Modeling

In this article, we revisit the importance of the generalized jackknife in the construction of reliable semi-parametric estimates of some parameters of extreme or even rare events. The generalized jackknife statistic is applied to a minimum-variance reduced-bias estimator of a positive extreme value index—a primary parameter in statistics of extremes. A couple of refinements are proposed and a simulation study shows that these are able to achieve a lower mean square error. A real data illustration is also provided.     

Improved model selection criteria for SETAR time series models

The purpose of this paper is threefold. First, we obtain the asymptotic properties of the modified model selection criteria proposed by Hurvich et al. (1990. Improved estimators of Kullback-Leibler information for autoregressive model selection in small samples. Biometrika 77, 709–719) for autoregressive models. Second, we provide some highlights on the better performance of this modified criteria. Third, we extend the modification introduced by these authors to model selection criteria commonly used in the class of self-exciting threshold autoregressive (SETAR) time series models. We show the improvements of the modified criteria in their finite sample performance. In particular, for small and medium sample size the frequency of selecting the true model improves for the consistent criteria and the root mean square error (RMSE) of prediction improves for the efficient criteria. These results are illustrated via simulation with SETAR models in which we assume that the threshold and the parameters are unknown.     

Regularization with Maximum Entropy and Quantum Electrodynamics: The Merg(E) Estimators

It is well-known that under fairly conditions linear regression becomes a powerful statistical tool. In practice, however, some of these conditions are usually not satisfied and regression models become ill-posed, implying that the application of traditional estimation methods may lead to non-unique or highly unstable solutions. Addressing this issue, in this paper a new class of maximum entropy estimators suitable for dealing with ill-posed models, namely for the estimation of regression models with small samples sizes affected by collinearity and outliers, is introduced. The performance of the new estimators is illustrated through several simulation studies.     

Assessing the relevance of higher education courses

The establishment of the European Higher Education Area has involved specifying lists of professional competencies that programs are expected to develop, and with this the need for procedures to measure how every course within a higher education program is aligned with the program's competencies. We propose an instrument for characterizing this alignment, a process that we call assessing the relevance of a course. Using information from the course syllabus (objectives, contents and assessment scheme), our instrument produces indicators for characterizing the syllabus in terms of a competence list and for assessing its coherence. Because assessment involves quality, the results obtained can also be used to revise and improve the course syllabus. We illustrate this process with an example of a methods course from a mathematics teacher education program at a Spanish university.