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961.
A robust Bayesian design is presented for a single-arm phase II trial with an early stopping rule to monitor a time to event endpoint. The assumed model is a piecewise exponential distribution with non-informative gamma priors on the hazard parameters in subintervals of a fixed follow up interval. As an additional comparator, we also define and evaluate a version of the design based on an assumed Weibull distribution. Except for the assumed models, the piecewise exponential and Weibull model based designs are identical to an established design that assumes an exponential event time distribution with an inverse gamma prior on the mean event time. The three designs are compared by simulation under several log-logistic and Weibull distributions having different shape parameters, and for different monitoring schedules. The simulations show that, compared to the exponential inverse gamma model based design, the piecewise exponential design has substantially better performance, with much higher probabilities of correctly stopping the trial early, and shorter and less variable trial duration, when the assumed median event time is unacceptably low. Compared to the Weibull model based design, the piecewise exponential design does a much better job of maintaining small incorrect stopping probabilities in cases where the true median survival time is desirably large. 相似文献
962.
Frank Heinemann Rosemarie Nagel Peter Ockenfels 《Econometrica : journal of the Econometric Society》2004,72(5):1583-1599
The theory of global games has shown that coordination games with multiple equilibria may have a unique equilibrium if certain parameters of the payoff function are private information instead of common knowledge. We report the results of an experiment designed to test the predictions of this theory. Comparing sessions with common and private information, we observe only small differences in behavior. For common information, subjects coordinate on threshold strategies that deviate from the global game solution towards the payoff‐dominant equilibrium. For private information, thresholds are closer to the global game solution than for common information. Variations in the payoff function affect behavior as predicted by comparative statics of the global game solution. Predictability of coordination points is about the same for both information conditions. 相似文献
963.
Ioannis Michalakoudis Marco Aurisicchio Peter Childs Apollon Koutlidis James Harding 《生产规划与管理》2018,29(8):688-703
A growing interest in knowledge management and standardisation, has increasingly led organisations to implement employee training programs. For the manufacturing workforce, however, these remain limited to informal ‘On-the-Job’ approaches, administered by peer colleagues – particularly in Small and Medium Enterprises (SMEs) where economic, educational, cognitive and cultural constraints are often deeply embedded. This paper proposes a methodology for training the manufacturing workforce on the functions of products, and presents a case study conducted in a UK-based manufacturing SME – aiming to verify our two research hypotheses: a) Functional Analysis Diagrams of the company’s products and parts would assist in knowledge assimilation; and, b) knowledge assimilation has a positive effect on work quality and productivity levels. By applying statistical inference methods on long-term quantitative data and survey results, we confirmed substantial improvements in work quality (63%) and increased productivity (67%), supporting our hypotheses and suggesting that the proposed methodology can be a promising solution for the industry. 相似文献
964.
Mohammed Almahmood Oliver Schulze Trine Agervig Carstensen Gertrud Jørgensen 《Planning Practice and Research》2018,33(2):186-210
Riyadh is one of the most gender-segregated cities in the world. However, as gender segregation is less enforced on sidewalks, it provides an optimal case study for a space where women and men may be co-present. Thus, this paper aims to increase the understanding of the relationship between sociocultural norms and spatial programming regarding spatio-temporal inclusion or exclusion in public urban spaces. The results show that women’s use and access to sidewalks are influenced by gender norms, religious values, gendered regulations, and generic spatial programming. For instance, regulations limit the use of outdoor seating to men only, thus sidewalks adjacent to, e.g., cafes function as mono-gender spaces dominated by men. However, young women negotiate spatially bounded gender norms through their presence, behaviour, and dress. Although sidewalks are conceived as men’s space, women account for nearly half of the users, but their use often goes unnoticed as women self-regulate their spatio-temporal and visible presence. The study presents six types of women’s spatio-temporal behaviours with varying degrees of visible and invisible users. Ultimately, this paper argues that planning for inclusive sidewalks cannot be addressed solely through the ‘universal’ characterization of space; it should also be supplemented by context-specific knowledge regarding the socio-spatial needs. 相似文献
965.
Tracey Peter 《Journal of homosexuality》2018,65(6):814-831
The goal of the study is to investigate whether positive mental health complements mental illness within a theoretically informed (the dual-continua model) and psychometrically tested (the Mental Health Continuum-Short Form) framework. National-level, population-based data from the 2012 Canadian Community Health Survey on Mental Health (CCHS-MH) was used, with comparisons between sexual minority and heterosexual adults. Results show that gay, lesbian, and bisexual Canadians have substantially lower rates of positive mental health and are more likely to have been diagnosed with a mental illness, with the disparities between health and illness being the most pronounced among lesbians and bisexual females. Results show considerable support for the dual-continua model, which posits that the absence of health does not automatically translate into the presence of illness, and vice versa. Suggestions are made for practitioners and researchers toward the use of the dual-continua model as a surveillance tool, especially among sexual minority individuals. 相似文献
966.
Journal of Population Research - Following a number of difficulties measuring net overseas migration (NOM), since 2006 the Australian Bureau of Statistics (ABS) has defined a usual resident of... 相似文献
967.
968.
Peter Sidebotham 《Child Abuse Review》2000,9(5):311-320
In order to study patterns of child abuse in a pre‐school population, we have looked at children within a local cohort who have been investigated for abuse or placed on the Child Protection Register. This is part of a larger study examining risk and protective factors for child abuse. Of 14 138 children enrolled in the cohort, 329 were investigated for suspected child abuse and 163 were placed on the Child Protection Register over an 8‐year period, representing rates of 10.6 – 23.3 per 10 000 per year. Physical injury and neglect accounted for 31.7% and 29.0% of registrations in the study group respectively, these proportions being similar to those for children of all ages in Avon. In contrast, sexual abuse accounted for 10.9% compared to 21.1% for all ages. Emotional abuse represented just 2.8% of investigations but 25.1% of all registrations in the study group, compared to 14.4% of registrations for all ages. Two hundred and fifty‐five (1.8%) parents reported physical cruelty to their children by themselves or their partner at some stage in the first 3 years; 772 (5.4%) reported some emotional cruelty. The importance of emotional cruelty to children is increasingly being recognized by professionals, but even more so by parents, whose concerns relating to both physical and emotional cruelty are not being identified by current procedures. Copyright © 2000 John Wiley & Sons, Ltd. 相似文献
969.
970.
Peter Loader 《Child Abuse Review》1998,7(1):44-57
Shame is a powerful emotion associated with the exposure of any aspect of the self that we wish to keep hidden from others. In its healthy manifestation, shame guards the boundary of the self and promotes a realistic self-appraisal of our capacities and our limitations. However, too much shame results in a sense of the self as fundamentally flawed, and can lead to lifelong problems in living. Shame originates in relationship to others, and most notably by how we are seen as children by our parents. This paper focuses on shame in the family context, the ways shame can be misused in the parent/child relationship and the effects of this on the child. Shame is put forward as an important, but neglected, consideration in child mental health and a core issue in child abuse. The implications for work with children and families are briefly discussed. © 1998 John Wiley & Sons, Ltd. 相似文献