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41.
For a dose finding study in cancer, the most successful dose (MSD), among a group of available doses, is that dose at which the overall success rate is the highest. This rate is the product of the rate of seeing non-toxicities together with the rate of tumor response. A successful dose finding trial in this context is one where we manage to identify the MSD in an efficient manner. In practice we may also need to consider algorithms for identifying the MSD which can incorporate certain restrictions, the most common restriction maintaining the estimated toxicity rate alone below some maximum rate. In this case the MSD may correspond to a different level than that for the unconstrained MSD and, in providing a final recommendation, it is important to underline that it is subject to the given constraint. We work with the approach described in O'Quigley et al. [Biometrics 2001; 57(4):1018-1029]. The focus of that work was dose finding in HIV where both information on toxicity and efficacy were almost immediately available. Recent cancer studies are beginning to fall under this same heading where, as before, toxicity can be quickly evaluated and, in addition, we can rely on biological markers or other measures of tumor response. Mindful of the particular context of cancer, our purpose here is to consider the methodology developed by O'Quigley et al. and its practical implementation. We also carry out a study on the doubly under-parameterized model, developed by O'Quigley et al. but not 相似文献
42.
Social Indicators Research - This paper addresses the following questions: Overall, on average, how did child and youthwell-being in the United States of Americachange in the last quarter of the... 相似文献
43.
The current crisis of neoliberalism is calling into question the relevance of key international institutions. We analyze the
origins, nature, and possible impacts of the crisis through comparing two such institutions: the International Monetary Fund
(IMF) and the World Trade Organization (WTO). Both originated in the post-World War II U.S.-led hegemonic order and were transformed
as part of the transition to global neoliberalism. We show that while the IMF and the WTO have been part of the same hegemonic
project, their distinct institutional features have put them on significantly different trajectories. Historical differences
in the two institutions’ systems of rules have placed the IMF in a more vulnerable position than the WTO, which provides clues
to the future contours of global economic governance.
Nitsan Chorev is Assistant Professor of Sociology at Brown University. She is the author of Remaking U.S. Trade Policy: from Protectionism to Globalization (Cornell University Press, 2007), and is now working on a book on the global politics of health. Sarah Babb is Associate Professor of Sociology at Boston College. She is the author of Behind the Development Banks: Washington Politics, World Poverty, and the Wealth of Nations (University of Chicago Press, 2009), which explores the impact of American politics on the World Bank and regional development institutions. 相似文献
Nitsan Chorev (Corresponding author)Email: |
Sarah BabbEmail: |
Nitsan Chorev is Assistant Professor of Sociology at Brown University. She is the author of Remaking U.S. Trade Policy: from Protectionism to Globalization (Cornell University Press, 2007), and is now working on a book on the global politics of health. Sarah Babb is Associate Professor of Sociology at Boston College. She is the author of Behind the Development Banks: Washington Politics, World Poverty, and the Wealth of Nations (University of Chicago Press, 2009), which explores the impact of American politics on the World Bank and regional development institutions. 相似文献
44.
45.
Ronald R. Rindfuss Minja Kim Choe Sarah R. Brauner-Otto 《Population research and policy review》2016,35(3):287-304
Beginning in 2000, in economically advanced countries, a remarkable bifurcation in fertility levels has emerged, with one group in the moderate range of period total fertility rates, about 1.9, and the other at 1.3. The upper branch consists of countries in Northern and Western Europe, Oceania and the United States; the lower branch includes Central, Southern, and Eastern Europe, and East and Southeast Asia. A review of the major theories for low-fertility countries reveals that none of them would have predicted this specific bifurcation. We argue that those countries with fertility levels close to replacement level have institutional arrangements, and related policies, that make it easier, not easy, for women to combine the worker and mother roles. The institutional details are quite different across countries, suggesting that multiple combinations of institutional arrangements and policies can lead to the same country-level fertility outcome. Canada, the only exception to this bifurcation, illustrates the importance of the different institutional structures in Québec compared to the rest of Canada. 相似文献
46.
Time of peak bat activity during the night differs among bat species due to temperature, prey availability, habitat availability, and/or interactions between species. Habitat availability is altered in urban areas, which may affect insect prey availability and interspecies interactions. Our objectives were to use mobile acoustic monitoring to determine when bat species were active in a single night in urban and nonurban sites and if nightly bat activity patterns differed in urban versus nonurban sites. Bat echolocation call sequences were recorded using Anabat acoustic detectors while driving transects through the night at five sites (three “urban” and two “nonurban”) located in the Piedmont region of north-central North Carolina from May through August 2016. Transects were driven three times per night starting 45 min, 180 min, and 300 min after sunset. Recorded echolocation call sequences were analyzed manually using AnalookW and automatically using Bat Call Identification and Echoclass software. Total bat activity was not different between urban and nonurban sites. However, total bat activity was lower later in the night in urban sites, but stayed the same in nonurban sites. Species specifically, there were more Eptesicus fuscus, Lasionycteris noctivagans, and Tadarida brasiliensis call sequences and fewer Lasiurus borealis, Nycticeius humeralis, and Perimyotis subflavus call sequences in urban sites than nonurban sites. There were also fewer E. fuscus, L. noctivagans, and N. humeralis call sequences later in the night in both urban and nonurban sites. Only Lasiurus borealis activity in urban sites later in the night reduced and L. borealis activity in nonurban sites remained at the same. These results suggest that bats in urban areas partition time differently, which is important to consider for urban conservation efforts and planning. 相似文献
47.
David T. Kryszajtys Tara E. Hahmann Andrée Schuler Sarah Hamilton-Wright Carolyn P. Ziegler Flora I. Matheson 《Journal of gambling studies / co-sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming》2018,34(3):893-914
Despite many studies indicating an association between problem gambling and delinquent behaviours among adolescents, there has been no effort to systematically analyze the state of the literature on this relationship. To fill this gap, we conducted a scoping review of the literature published between 2000 and 2016 on problem gambling and delinquent behaviours among adolescents. We searched twelve databases and reviewed reference lists to identify eligible studies. Search terms included a combination of medical subject headings and keywords for gambling, youth, and delinquency, which were combined with the Boolean operator “AND”. 1795 studies were identified through the literature search. Nine studies were eligible for inclusion. All of the studies were conducted in North America, with primarily male participants, and most of the data were cross-sectional. No qualitative studies met the inclusion criteria. Screening tools used to measure problem gambling were inconsistent, making comparisons across studies difficult. We found a consistent moderate to strong association between problem gambling and delinquent behaviour. Only one study presented associations by socio-economic status and none considered gender, sex or ethnic differences. Studies in the review showed that problem gambling is associated with both violent and non-violent behaviours among adolescents. These associations may suggest that problem gambling and delinquent behaviours have common risk factors and reflect a syndrome of risky behaviours best targeted through prevention and treatment that is holistic and considers the context in which the youth is situated. Further research is warranted to better understand the relationship between problem gambling and delinquent behaviours. 相似文献
48.
Melissa D. Grady Traci Wike Caren Putzu Sara Field Jacqueline Hill Sarah E. Bledsoe 《Journal of Social Work Education》2018,54(1):163-179
The aim of this study was to evaluate how CSWE’s 2008 shift placing more emphasis on research have affected newly trained social workers’ use of evidence-based practice (EBP). This qualitative study examined the educational and practice experiences of newly trained social workers and how those experiences influence the use of EBP and empirically supported interventions/treatments in the field. Thirteen newly graduated social workers were interviewed using a semi-structured interview. Twenty-three codes emerged from the interviews, with the most prominent theme being a sense of overall confusion about EBP. Other themes included lack of educational preparation, lack of agency resources, and prohibitive agency culture. Implications for social work education and practice are discussed. 相似文献
49.
Claire Ferguson Sarah Wright Jodi Death Kylie Burgess John Malouff 《Journal of Child Custody》2018,15(2):93-115
This study examined Family Court of Australia (FCA) judicial determinations in parenting disputes when allegations of child sexual abuse (CSA) are made by an interested party, usually the mother. For the study, 156 published judgments from 2013–2015 were examined to measure how often allegations of CSA are substantiated, suspected to be true, and disbelieved. The characteristics most common in substantiated versus unsubstantiated cases, evidence of abuse presented, and resulting parenting orders were assessed. Findings indicate that, against international comparisons, FCA judges substantiate cases very conservatively, with rates of substantiation much lower than in other studies. Allegations made by mothers against fathers were disproportionately unsubstantiated, as were those which did not fall under the Magellan case management system. Cases where the only evidence of CSA was a child’s disclosure and parent’s allegation were common in both substantiated and unsubstantiated cases, meaning that a lack of other evidence does not preclude a positive finding of risk of CSA by the FCA. Those cases also involving a protection order against the accused were more likely to be substantiated. Confirmation biases and a judicial tendency to err on the side of false negatives are discussed. 相似文献
50.
Daniel Aggio Olia Papacosta Lucy T. Lennon Sarah Ash Peter H. Whincup S. Goya Wannamethee Barbara J. Jefferis 《European review of aging and physical activity》2018,15(1):16