Evaluation of dependent variable,time effect,covariates, and covariation structure in concentration‐QTc modeling: A simulation study

The revised ICH E14 Question and Answer (R3) document issued in December 2015 enables pharmaceutical companies to use concentration‐QTc (C‐QTc) modeling as the primary analysis for assessing QTc prolongation risk of new drugs. A new approach by including the time effect into the current C‐QTc model is introduced. Through a simulation study, we evaluated performances of different C‐QTc modeling with different dependent variables, covariates, and covariance structures. This simulation study shows that C‐QTc models with ΔQTc being dependent variable without time effect inflate false negative rate and that fitting C‐QTc models with different dependent variables, covariates, and covariance structures impacts the control of false negative and false positive rates. Appropriate C‐QTc modeling strategies with good control of false negative rate and false positive rate are recommended.     

“FOB” and “Whitewashed”: Identity and Internalized Racism Among Second Generation Asian Americans

An analysis of 184 in-depth interviews with grown children of Korean and Vietnamese immigrants finds that the racial beliefs, meanings, and stereotypes of the mainstream society shape how they think about coethnics, generate local identities, and deflect stigma from themselves. We examine the terms FOB (Fresh Off the Boat) and whitewashed that were commonly deployed to denigrate coethnic others as too ethnic or too assimilated while casting those at the bicultural middle as the normals. We describe how this system of intraethnic othering serves as a basis for sub-ethnic identities, intraethnic social boundaries, and the monitoring and control of social behavior. We draw on the concept of internalized racial oppression in framing our findings.     

激光涂敷多种硬质合金的性能及形成机理之研究

叙述了利用一台输出功率为2kW的连续CO_2激光器在20~#钢表面涂敷WC—TiN—SiC—Co和WC—SiC—Co的研究,并对激光处理后的涂敷层进行了物相分析和硬度分布以及耐磨性能的测试。其结果表明:利用高功率激光束可在廉价的碳钢表面实现多种硬质合金的涂敷,其表面的化学成分发生了根本性的改变,机械性能有了极大的提高。同时对涂敷层的形成机理进行了探讨。     

公民隐私权利的宪法保护——深圳“电子眼事件”引发的法律思考

深圳“电子眼事件”引发了人们对宪法保护公民隐私权利的思考。考察公民隐私权利的发展历程可以看到,美国和以德国、法国为代表的欧洲国家高度重视公民隐私权利保护工作,立法和司法实践都对隐私权利作出了具体规定：宪政发达的国家将隐私权利作为公民实现自我、发展自我的一项重要权利,将隐私权等同于自由、基本人格和人的尊严,视隐私权为一项基本人权：相比之下,我国宪法在保护公民隐私权利方面从基本内容到程序保障均亟待完善：因此,改革现行宪法,保护公民隐私权成为解决问题的关键所在。     

域外信息摄取方式的变迁

信息爆炸导致域外信息摄取方式发生了很大的变化,由全译主导变为变译主导。变译的方法主要有增、减、摘、编、述和写,策略主要有摘译、编译、译述、译写等。变译可以突出原作的使用价值,提高信息传递的社会效率等。     

如何理解老龄社会及其特点

文章在提出“社会构架”这一重要概念的基础上,探讨了人口年龄结构和社会构架之间的关系,认为老龄社会是从人口年龄结构和社会构架关系的角度来识别人类社会形态的一个新范畴。通过比较青年型、成年型和老年型人口年龄结构及其相对应的社会构架的差异,从形态学的角度描述和分析了老龄社会的基本特征,即老龄社会是一种全新的社会主体构成,在经济结构、社会结构和政治结构以及文化价值导向等方面区别于青年型和成年型两类社会。     

语言暴力的类型研究

本文分析语言暴力的类型及其危害,旨在营造良好的语言环境。     

Does Horizontal Inequality Matter in Vietnam?

This paper examines the issue of horizontal inequalities in Vietnam over the past 20 years. Using data from three recent Vietnam population censuses (1989, 1999, and 2009) and three Vietnam Household Living Standard Surveys (1998, 2008, 2012), we estimated numerous measures on inequalities between five groups against four welfare indicators. Our results show that horizontal inequality matters in Vietnam, in particular for ethnicity, region, and rural/urban groups. While there has been an improvement in horizontal inequality in education, this paper shows little change in other welfare indicators, in particular poverty. We also found that horizontal inequality does matter for poverty reduction in Vietnam and it needs more attention when designing poverty policies in the future.

     

中国古代文论的“当代性”意义生成问题

"当代性"是传统文论的资源价值意义与当代文论话语建构的理论资源诉求相适应的一种理论视域,是传统文论参与当代文论话语建设的切入点,也是传统文论与当代文论互相融通的内在结合点."当代性"实际上体现、渗透在现代阐释之中.从本质上看,经过系统的整理与阐释,回到古代文论的原生形态,寻找其新的理论视野和理论生长点,既能超越百年来学界谈论古代文论的"合法性"危机问题,又可以克服当前文艺学研究繁荣景象背后所显露的文化无根性困境,其意义和价值是不言而喻的.     

我国证券经纪人流动问题的动态稳定控制研究

证券行业是影响和推动我国经济发展的重要行业。证券经纪人的稳定与否对于证券行业的稳定健康发展至关重要。我国目前证券经纪人流动太过频繁和无序的状况,为我国证券行业、证券公司乃至证券经纪人本身的发展都带来了极大的不稳定因素。对此,利用现代控制理论中鲁棒控制的思想和求解线性矩阵不等式的模型,研究和讨论证券经纪人达到鲁棒稳定的线性矩阵不等式可行解的存在性,并通过对HT证券公司的实例分析,验证所给模型及控制方法的可行性和实用性,可为解决证券经纪人无序、繁杂流动问题提供新的思路和方法。