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In longitudinal biomedical studies, there is often interest in the rate functions, which describe the functional rates of change of biomarker profiles. This paper proposes a semiparametric approach to model these functions as the realizations of stochastic processes defined by stochastic differential equations. These processes are dependent on the covariates of interest and vary around a specified parametric function. An efficient Markov chain Monte Carlo algorithm is developed for inference. The proposed method is compared with several existing methods in terms of goodness-of-fit and more importantly the ability to forecast future functional data in a simulation study. The proposed methodology is applied to prostate-specific antigen profiles for illustration. Supplementary materials for this paper are available online.  相似文献   
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The 2010 Coalition has set itself the challenge of combining an unprecedentedly rapid and profound retrenchment with a fundamental restructuring of the public sector, both to be accomplished within five years. The immediate justification is a presumed need to reduce national indebtedness. The longer‐term goal is to shrink the state, free up the market and set British political economy on a new course. The programme has encountered a number of set‐backs and some elements appear more likely to be realized than others. This article considers the objectives of the Coalition programme and the likely outcomes, using evidence from a number of sources including comparisons with the experience of retrenchment elsewhere and analysis of previous rounds of public spending cut‐backs.  相似文献   
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Social work and health care professionals internationally are recognizing the need to understand and respond to the abuse of older people. Policy and guidance have identified processes but definitions of key concepts remain problematic, and the literature suggests that practitioners and agencies have little insight or guidance for decision making. Nine bibliographic databases were searched for studies on professional decision making regarding abuse of older people. Relevant studies retrieved were appraised for quality using explicit criteria. The findings of the 19 articles meeting the inclusion criteria were synthesised using a structured narrative approach. Common themes identified were abuse factors, situational factors, and broader contextual factors. Abuse factors relating to risk levels and client vulnerability were central; age, gender, and health status were considered as key indicators of vulnerability. The opinion of adult protection workers about the potential effectiveness of their intervention was a factor in deciding about responding to alleged or suspected abuse. Professionals struggled with complex ethical dilemmas created by elder abuse, particularly when the victim did not want an investigation. Making objective judgements was difficult when faced with complex family and contextual factors. A structured approach to narrative synthesis of a diverse range of studies retrieved through an explicit search and inclusion process provided a useful summary of key issues for practice and identified gaps in the research literature.  相似文献   
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This paper presents a conceptual framework for viewing social planning and social administration as one “seamless web” of activity concerned with the identification of goals and the development of appropriate administrative structures for their implementation. The major educational implication of this analysis is that curriculum planning should maximize the integration of social policy, social planning, and administration. Alternative approaches to achieving this integration are discussed using data from a recent Council on Social Work Education survey.  相似文献   
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Abstract

In social work education, almost all efforts to teach quantitative analysis are relegated to statistics and research courses. This approach suggests that the only value of quantitative thinking is in formal research. Arguing to the contrary, this paper outlines some reasons why numeracy is essential to day-to-day social work practice. The mathematics preparation of social work students is reviewed and some attributes of the numerate practitioner are described. Some beginning steps are recommended to implement the proposed instructional strategy of integrating real-life quantitative modules in the curriculum.

Numerate: marked by the capacity for quantitative thought and expression (Webster's, 1985)  相似文献   
130.
This article focuses on lesbian and gay couples and families and the politics of same‐sex marriage. Drawing from the literature on same‐sex couples, same‐sex marriage, and queer theory’s concept of heteronormativity, we argue that gay and lesbian couples and families both affirm and challenge heterosexual and gendered family forms. First, we review literature that discusses how same‐sex relationships and families are similar to and different from conventional heterosexual relationships and families. Second, we discuss the socio‐legal and cultural inequalities faced by LGBT families. Third, we discuss the politics of same‐sex marriage, examining the debate among social conservatives, pro‐marriage activists, and queer critics over the desirability of same‐sex marriage. We conclude that the growing visibility of LGBT couples and families has made their exclusion from the institution of marriage more conspicuous and that recognition of LGBT relationships and families seems likely to increase.  相似文献   
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