Hexavalent Chromium and Lung Cancer in the Chromate Industry: A Quantitative Risk Assessment

The purpose of this investigation was to estimate excess lifetime risk of lung cancer death resulting from occupational exposure to hexavalent-chromium-containing dusts and mists. The mortality experience in a previously studied cohort of 2,357 chromate chemical production workers with 122 lung cancer deaths was analyzed with Poisson regression methods. Extensive records of air samples evaluated for water-soluble total hexavalent chromium were available for the entire employment history of this cohort. Six different models of exposure-response for hexavalent chromium were evaluated by comparing deviances and inspection of cubic splines. Smoking (pack-years) imputed from cigarette use at hire was included in the model. Lifetime risks of lung cancer death from exposure to hexavalent chromium (assuming up to 45 years of exposure) were estimated using an actuarial calculation that accounts for competing causes of death. A linear relative rate model gave a good and readily interpretable fit to the data. The estimated rate ratio for 1 mg/m3-yr of cumulative exposure to hexavalent chromium (as CrO3), with a lag of five years, was RR=2.44 (95% CI=1.54-3.83). The excess lifetime risk of lung cancer death from exposure to hexavalent chromium at the current OSHA permissible exposure limit (PEL) (0.10 mg/m3) was estimated to be 255 per 1,000 (95% CI: 109-416). This estimate is comparable to previous estimates by U.S. EPA, California EPA, and OSHA using different occupational data. Our analysis predicts that current occupational standards for hexavalent chromium permit a lifetime excess risk of dying of lung cancer that exceeds 1 in 10, which is consistent with previous risk assessments.     

Marital Therapy and Feminism

The authors examine first the meaning ascribed to gender behaviour and the impact this has on couples' struggle to evolve a marital structure that can equitably meet their needs. The roles played by counsellors who inadvertently reinforce sex-role stereotyping in their counselling is also described and case-discussion in literature where sexism prevails will be presented. Alternative ways of helping couples discover their own fit without appealing to gender behaviour as a structural social tool will be developed. Attention is drawn to the necessity for counsellors to first question their own values about gender behaviour, without succumbing to social definitions.     

Preference for Sons,Family Size,and Sex Ratio: An Empirical Study in Korea

This study investigates the effects of son preference on sex ratio and fertility at the family level, utilizing World Fertility Survey data for Korea, whose population is known to have a strong preference for sons and a fairly high level of contraceptive use. The sex ratio (number of males per 100 females) of siblings in small families is considerably higher than in large families. The sex ratio of last-born children in families of any size is markedly higher than that of the previous children. The sex distribution of children for a given family size, if less than five, deviates significantly from the Bernoulli sequence. The observed frequency of all-girl families is especially small in comparison with the expected value. The sex of the last child strongly influences couples' decision making regarding additional births in all steps of family building except for bearing a second child. In increasing their families to moderate size, parents appear to take into consideration the sex distribution of all earlier births.     

Some asymptotic properties in INAR(1) processes with Poisson marginals

The first-order integer-valued autoregressive (INAR(1)) process with Poisson marginal distributions is considered. It is shown that the sample autocovariance function of the model is asymptotically normally distributed. We derive asymptotic distribution of Yule-Walker type estimators of parameters. It turns out that our Yule-Walker type estimators are better than the conditional least squares estimators proposed by Klimko and Nelson (1978) and Al-Osh and Alzaid (1987). also, we study the relationship between the model andM/M/∞ queueing system.     

A Search for Thresholds and Other Nonlinearities in the Relationship Between Hexavalent Chromium and Lung Cancer

The exposure-response relationship for airborne hexavalent chromium exposure and lung cancer mortality is well described by a linear relative rate model. However, categorical analyses have been interpreted to suggest the presence of a threshold. This study investigates nonlinear features of the exposure response in a cohort of 2,357 chemical workers with 122 lung cancer deaths. In Poisson regression, a simple model representing a two-step carcinogenesis process was evaluated. In a one-stage context, fractional polynomials were investigated. Cumulative exposure dose metrics were examined corresponding to cumulative exposure thresholds, exposure intensity (concentration) thresholds, dose-rate effects, and declining burden of accumulated effect on future risk. A simple two-stage model of carcinogenesis provided no improvement in fit. The best-fitting one-stage models used simple cumulative exposure with no threshold for exposure intensity and had sufficient power to rule out thresholds as large as 30 microg/m3 CrO3 (16 microg/m3 as Cr+6) (one-sided 95% confidence limit, likelihood ratio test). Slightly better-fitting models were observed with cumulative exposure thresholds of 0.03 and 0.5 mg-yr/m3 (as CrO3) with and without an exposure-race interaction term, respectively. With the best model, cumulative exposure thresholds as large as 0.4 mg-yr/m3 CrO3 were excluded (two-sided upper 95% confidence limit, likelihood ratio test). A small departure from dose-rate linearity was observed, corresponding to (intensity)0.8 but was not statistically significant. Models in which risk-inducing damage burdens declined over time, based on half-lives ranging from 0.1 to 40 years, fit less well than assuming a constant burden. A half-life of 8 years or less was excluded (one-sided 95% confidence limit). Examination of nonlinear features of the hexavalent chromium-lung cancer exposure response in a population used in a recent risk assessment supports using the traditional (lagged) cumulative exposure paradigm: no intensity (concentration) threshold, linearity in intensity, and constant increment in risk following exposure.     

Dispersive ordering—Some applications and examples

A basic concept for comparing spread among probability distributions is that of dispersive ordering. Let X and Y be two random variables with distribution functions F and G, respectively. Let F ⁻¹ and G ⁻¹ be their right continuous inverses (quantile functions). We say that Y is less dispersed than X (Y≤ _disp X) if G ⁻¹(β)−G ⁻¹(α)≤F ⁻¹(β)−F ⁻¹(α), for all 0<α≤β<1. This means that the difference between any two quantiles of G is smaller than the difference between the corresponding quantiles of F. A consequence of Y≤ _disp X is that |Y ₁−Y ₂| is stochastically smaller than |X ₁−X ₂| and this in turn implies var(Y)≤var(X) as well as E[|Y ₁−Y ₂|]≤E[|X ₁−X ₂|], where X ₁, X ₂ (Y ₁, Y ₂) are two independent copies of X(Y). In this review paper, we give several examples and applications of dispersive ordering in statistics. Examples include those related to order statistics, spacings, convolution of non-identically distributed random variables and epoch times of non-homogeneous Poisson processes. This work was supported in part by KOSEF through Statistical Research Center for Complex Systems at Seoul National University. Subhash Kochar is thankful to Dr. B. Khaledi for many helpful discussions.     

Construction of central composite designs for balanced orthogonal blocks

Box & Hunter (1957) recommended a set of orthogonally blocked central composite designs (CCD) when the region of interest is spherical. In order to achieve rotatability along with orthogonal blocking, the block size for those designs becomes unequal and it may not be attractive or practical to use such unequally blocked designs in many practical situations. In this paper, a construction method of orthogonally blocked CCD under the assumption of equal block size is proposed and an index of block orthogonality is introduced.     

Popular Support for Democracy and its Institutions in Korea: The Dynamics and Sources of Regime Support and Institutional Trust

This article examines the contours and dynamics of popular support for democracy in South Korea, a country widely known as one of the most successful third-wave democracies in Asia. Analysis of the Korea Democracy Barometer and East Asia Barometer surveys conducted between 1996 and 2004 reveals that ordinary Koreans’ support for democracy has moved both downward and upward during the past eight years. Analysis of these surveys also reveals that the trajectories and sources of that movement vary considerably across different types of democratic support. Based on this finding that democratic authorization and exercise of power affect various manifestations of democratic support differently, we argue that to understand the dynamics of support for democracy accurately, one must distinguish between the realm of political performance and that of governmental performance.