On sequential closed testing dose groups with a control

Methods for a sequential test of a dose-response effect in pre-clinical studies are investigated. The objective of the test procedure is to compare several dose groups with a zero-dose control. The sequential testing is conducted within a closed family of one-sided tests. The procedures investigated are based on a monotonicity assumption. These closed procedures strongly control the familywise error rate while providing information about the shape of the dose-responce relationship. Performance of sequential testing procedures are compared via a Monte Carlo simulation study. We illustrae the procedures by application to a real data set.     

Generalized additive mixed models

Following the extension from linear mixed models to additive mixed models, extension from generalized linear mixed models to generalized additive mixed models is made, Algorithms are developed to compute the MLE's of the nonlinear effects and the covariance structures based on the penalized marginal likelihood. Convergence of the algorithms and selection of the smooth param¬eters are discussed.     

Regression Properties for Asymmetric Generalized Scale Mixtures of Multivariate Gaussian Variables

Analytical properties of regression and the variance–covariance matrix of asymmetric generalized scale mixture of multivariate Gaussian variables are presented. The analysis includes an in-depth analytical investigation of the first two conditional moments of the mixing variable. Exact computable expressions for the prediction and the conditional variance are presented for the generalized hyperbolic distribution using the inversion theorem for Fourier transforms. An application to financial log returns is demonstrated via the classical Euler approximation. The methodology is illustrated by analyzing the regression of intraday log returns for CISCO against the corresponding data from S&P 500.     

Testing Treatment-Covariate Interaction in a Nonparametric Analysis of Covariance Model

We consider a recently introduced nonparametric model for Analysis of Covariance and derive an asymptotic test for interaction between covariate and treatment. Furthermore, we suggest data depth techniques to obtain joint confidence regions for the covariate effects in this model.

The finite sample behavior of the asymptotic method is evaluated in simulations. Application of the procedures is illustrated using an epileptic seizures and chemotherapy data set.     

On concurrence of several linear regressions and applications to problems of enzyme kinetics

In comparing several regressions E(y_ij) =α_i + β_ix_ij i = 1, 2, ..., k, j = 1,2, ..., n_i, researchers are generally interested in the following five problems: whether they have (1) equal slope, (2) equal intercept, (3) coincidence, (4) common intersection on X-axis, and (5) common intersection on (X,Y) - plane. Problems (1) - (3) can be put into the framework of the general linear hypothesis and the F-test can be used. However, problems (4) and (5) cannot be put into the general linear hypothesis because they are ratios of parameters. Hence, in this paper we consider the generalized likelihood ratio test for hypothesis testing. An application to an enzyme kinetics problem in Aniline Metabolism is demonstrated     

Sample size determinations when two binomial proportions are very small

Sample size determination for testing the hypothesis of equality of proportions with a specified type I and type I1 error probabilitiesis of ten based on normal approximation to the binomial distribution. When the proportionsinvolved are very small, the exact distribution of the test statistic may not follow the assumed distribution. Consequently, the sample size determined by the test statistic may not result in the sespecifiederror probabilities. In this paper the author proposes a square root formula and compares it with several existing sample size approximation methods. It is found that with small proportion (p≦.01) the squar eroot formula provides the closest approximation to the exact sample sizes which attain a specified type I and type II error probabilities. Thes quare root formula is simple inform and has the advantage that equal differencesare equally detectable.     

The Modified Pulak and Al-Sultan's Model for Determining the Optimum Process Parameters

Economic selection of process parameters has been an important topic in modern statistical process control. The optimum process parameters setting have a major effect on the expected profit/cost per item. There are some concerns on the problem of setting process parameters. Boucher and Jafari (1991 Boucher , T. O. , Jafari , M. A. ( 1991 ). The optimum target value for single filling operations with quality sampling plans . J. Qual. Technol. 23 : 44 – 47 . [CSA] [Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) first considered the attribute single sampling plan applied in the selection of process target. Pulak and Al-Sultan (1996 Pulak , M. F. S. , Al-Sultan , K. S. ( 1996 ). The optimum targeting for a single filling operation with rectifying inspection . Omega 24 : 727 – 733 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] , [Google Scholar]) extended Boucher and Jafari's model and presented the rectifying inspection plan for determining the optimum process mean. In this article, we further propose a modified Pulak and Al-Sultan model for determining the optimum process mean and standard deviation under the rectifying inspection plan with the average outgoing quality limit (AOQL) protection. Taguchi's (1986 Taguchi , G. ( 1986 ). Introduction to Quality Engineering . Asian Productivity Organization . [Google Scholar]) symmetric quadratic quality loss function is adopted for evaluating the product quality. By solving the modified model, we can obtain the optimum process parameters with the maximum expected profit per item and the specified quality level can be reached.     

A Multiple Imputation Approach to the Analysis of Current Status Data with the Additive Hazards Model

This article discusses regression analysis of current status data, which occur in many fields including cross-sectional studies, demographical investigations, and tumorigenicity experiments (Keiding, 1991 Keiding , N. ( 1991 ). Age-specific incidence and prevalence: a statistical perspective (with discussion) . J. Roy. Statist. Soc. Ser. A 154 : 371 – 412 .[Crossref] , [Google Scholar]; Sun 2006 Sun , J. ( 2006 ). The Statistical Analysis of Interval-Censored Failure Time Data . New York : Springer-Verlag . [Google Scholar]). For the problem, we focus on the situation where the survival time of interest can be described by the additive hazards model and a multiple imputation approach is presented for inference. A major advantage of the approach is its simplicity and it can be easily implemented by using the existing software packages for right-censored failure time data. Extensive simulation studies are conducted and indicate that the approach performs well for practical situations and is comparable to the existing methods. The methodology is applied to a set of current status data arising from a tumorigenicity experiment and the model checking is discussed.     

A stepwise approach for the purely periodic interaction spline model

The basic idea of an interaction spline model was presented in Barry (1983). The general interaction spline models were proposed by Wahba (1986). The purely periodic spline model, a special case of the general interaction spline models, is considered in this paper. A stepwise approach using generalized cross validation (GCV) for fitting the model is proposed. Based on the nice orthogonality properties of the purely periodic functions, the stepwise approach is a promising method for the interaction spline model. The approach can also be generalized to the non-purely-periodic spline models. But this is no done here.     

Exact confidence bounds for an exponential parameter under hybrid censoring

Consider a life testing experiment in which n units are put on test, successive failure times are recorded, and the observation is terminated either at a specified number r of failures or a specified time T whichever is reached first. This mixture of type I and type II censoring schemes, called hybrid censoring, is of wide use. Under this censoring scheme and the assumption of an exponential life distribution, the distribution of the maximum likelihood estimator of the mean life θ is derived. It is then used to construct an exact lower confidence bound for θ.