西部边疆地区人力资源开发研究

人力资源的开发是地区经济和社会可持续发展的关键。我国西部边疆的5个省、区既是经济欠发达地区,又是多民族聚居地区。长期以来,人力资源开发滞后制约着地区的可持续发展。本文分析西部边疆5个省、区地区人力资源开发存在的问题,并提出相应的对策。     

拉达克王国：公元950—1842年（五）——拉达克力量的衰退

本文论述了17世纪下半叶拉达克王国在来自喀什噶尔的突厥人和来自卫藏的蒙古一西藏军队的双重打击下,逐步走向衰落的历史进程,从而结束了拉达克王国作为喜马拉雅地区重要力量的角色。     

A simple two-stage design for quantitative responses with application to a study in diabetic neuropathic pain

Two-stage designs offer substantial advantages for early phase II studies. The interim analysis following the first stage allows the study to be stopped for futility, or more positively, it might lead to early progression to the trials needed for late phase II and phase III. If the study is to continue to its second stage, then there is an opportunity for a revision of the total sample size. Two-stage designs have been implemented widely in oncology studies in which there is a single treatment arm and patient responses are binary. In this paper the case of two-arm comparative studies in which responses are quantitative is considered. This setting is common in therapeutic areas other than oncology. It will be assumed that observations are normally distributed, but that there is some doubt concerning their standard deviation, motivating the need for sample size review. The work reported has been motivated by a study in diabetic neuropathic pain, and the development of the design for that trial is described in detail.     

Models for the analysis of C-reactive protein in statin trials

Elevation in C-reactive protein (CRP) is an independent risk factor for cardiovascular disease progression and levels are reduced by treatment with statins. However, on-treatment CRP, given baseline CRP and treatment, is not normally distributed and outliers exist even when transformations are applied. Although classical non-parametric tests address some of these issues, they do not enable straightforward inclusion of covariate information. The aims of this study were to produce a model that improved efficiency and accuracy of analysis of CRP data. Estimation of treatment effects and identification of outliers were addressed using controlled trials of rosuvastatin. The robust statistical technique of MM-estimation was used to fit models to data in the presence of outliers and was compared with least-squares estimation. To develop the model, appropriate transformations of the response and baseline variables were selected. The model was used to investigate how on-treatment CRP related to baseline CRP and estimated treatment effects with rosuvastatin. On comparing least-squares and MM-estimation, MM-estimation was superior to least-squares estimation in that parameter estimates were more efficient and outliers were clearly identified. Relative reductions in CRP were higher at higher baseline CRP levels. There was also evidence of a dose-response relationship between CRP reductions from baseline and rosuvastatin. Several large outliers were identified, although there did not appear to be any relationships between the incidence of outliers and treatments. In conclusion, using robust estimation to model CRP data is superior to least-squares estimation and non-parametric tests in terms of efficiency, outlier identification and the ability to include covariate information.     

Analysis of quality-of-life adjusted failure time data in the presence of competing, possibly informative, censoring mechanisms

We derive estimators of the mean of a function of a quality-of-life adjusted failure time, in the presence of competing right censoring mechanisms. Our approach allows for the possibility that some or all of the competing censoring mechanisms are associated with the endpoint, even after adjustment for recorded prognostic factors, with the degree of residual association possibly different for distinct censoring processes. Our methods generalize from a single to many censoring processes and from ignorable to non-ignorable censoring processes.     

Missing item imputation for quality-of-life instruments with application to asthma quality-of-life questionnaires

There has been increasing use of quality-of-life (QoL) instruments in drug development. Missing item values often occur in QoL data. A common approach to solve this problem is to impute the missing values before scoring. Several imputation procedures, such as imputing with the most correlated item and imputing with a row/column model or an item response model, have been proposed. We examine these procedures using data from two clinical trials, in which the original asthma quality-of-life questionnaire (AQLQ) and the miniAQLQ were used. We propose two modifications to existing procedures: truncating the imputed values to eliminate outliers and using the proportional odds model as the item response model for imputation. We also propose a novel imputation method based on a semi-parametric beta regression so that the imputed value is always in the correct range and illustrate how this approach can easily be implemented in commonly used statistical software. To compare these approaches, we deleted 5% of item values in the data according to three different missingness mechanisms, imputed them using these approaches and compared the imputed values with the true values. Our comparison showed that the row/column-model-based imputation with truncation generally performed better, whereas our new approach had better performance under a number scenarios.     

和谐视域下高等教育入学机会均等研究

社会和谐是我们党不懈奋斗的目标,实现社会公平又是和谐社会的关键环节和重要特征.在当今中国,最大的社会公平就是教育公平尤其是高等教育入学机会均等,因为高等教育入学机会均等直接反映和影响社会公平,因此,保障高等教育入学机会均等对于构建和谐社会具有重要现实意义.笔者阐述高等教育入学机会均等在构建和谐社会中的意义并分析现状,提出保障高等教育入学机会均等的若干建议.     

族群认同感建构的社会学分析:以新疆“民考汉”为例

关于族群认同的讨论已成为社会学族际关系研究的一个重要视角.本项研究以新疆地区的一个特殊群体--"民考汉"为例,探讨影响族群性的文化特征与主观认同,并试图对影响"民考汉"族群认同的民族结构和制度安排进行客观的分析.     

复活的记忆——却西德哇传统村运会的应用人类学研究

"阿米嘉顶之韵——却西德哇传统村运会"是由人类学者发起的一项旨在复活当地传统体育游戏、歌舞和其他古老传统的应用人类学项目。本文描述了面对传统文化的衰落,人类学者在青藏高原东北部一个名为却西德哇的藏族村落与村民对话和共同行动的过程。此外,本文还就本次实践在非物质文化遗产保护方面取得的经验做了讨论。     

浅析教育信息化进程中基础设施的发展

实现教育信息化发展需要加强基础设施建设,在教育信息化发展道路中,加强信息设施的建设与发展是我国政府长期以来最为关注的话题.我国基础设施的建设起步比较晚,体系不够完善,建设水平较低,缺乏宏观调控意识,未制定合理的设备运行机制降低设施的利用效益.为此,笔者针对教育信息化进程中基础设施的发展进行深入探讨,通过关注数字化校园建设,提升我国教育信息化建设的发展水平.