Error catastrophe in mutant mitochondria

The error catastrophe theory of aging, proposed by Orgel in 1963, predicted a decrease in the fidelity of information transfer that accelerated as aging progressed, until properly functioning macromolecules could no longer be reliably made. The theory was extensively tested by comparing DNA polymerases, transfer RNAs, and proteins derived from aging versus young animals, but it did not prove to have general applicability to the process of aging. Recently, the heritable eye disorder progressive external ophthalmoplegia has been found to result from mutation of the gene encoding DNA polymerase gamma, which replicates mitochondrial DNA. The mutant form of the polymerase replicates DNA less accurately than the wild-type enzyme, providing an explanation for the accumulation of mutations in the mitochondrial DNA of patients with this disorder. The affected mitochondria appear to exhibit an age-dependent error catastrophe. It is possible that other genetic diseases might result in error catastrophes in mitochondria as well.     

Welfare generosity, pregnancies and abortions among unmarried AFDC recipients

Even before the 1996 overhaul of the U.S. welfare system, a number of states had ended the practice of paying extra benefits to families who have additional children while receiving welfare. Proponents believe that this reform can reduce births to recipients, however many worry that it may encourage women to obtain abortions. Using a sample of unmarried AFDC recipients from the NLSY, we estimate a bivariate probit model of pregnancy and, conditional on becoming pregnant, the probability of abortion. Our results lend some support for the proposition that reducing incremental AFDC benefits will decrease pregnancies without increasing abortions. Received: 16 April 1998/Accepted: 11 March 1999     

Realistic Major Previews in the School‐to‐College Transition of Italian High School Students

Industrial/organizational researchers have reported that realistic job previews diminish prospective workers' expectations but promote the satisfaction and persistence of those who ultimately accept a job assignment. The authors applied this strategy to the context of school‐to‐college transition; 354 Italian high school students were provided with a 2‐hour lecture designed to simulate exposure to a college major of their choice. Students showed moderate pre‐post increases in subject matter knowledge but reported small decreases in interests and outcome expectations (but not self‐efficacy) related to the academic major to which they were exposed.     

Problem Gambling Inside and Out: The Assessment of Community and Institutional Problem Gambling in the Canadian Correctional System

This paper reports on the results of a multi-site survey of gambling behaviour and gambling problems amongst offenders in correctional institutions in Ontario, Canada, conducted between 2008 and 2011. A total of 422 (completion rate 61.5 %) incarcerated offenders (381 male and 41 female) took part in the study including 301 federal offenders and 121 provincial offenders. Based on the Problem Gambling Severity Index of the Canadian Problem Gambling Index (CPGI/PGSI) the prevalence rate of severe problem gambling was 8.9 prior to incarceration and 4.4 % during incarceration. These numbers are substantially higher than rates found among the general public. Thirty-four percent of the sample reported gambling in prison. Half of those who suffered from gambling problems before incarceration continued to have gambling problems during incarceration. People with problems related to slot machines prior to incarceration reported fewer gambling problems during incarceration compared to other problem gamblers.     

'You've gotta learn how to play the game': homeless women's use of gender performance as a tool for preventing victimization

As a masculinist space, ‘the streets’ present a variety of dangers to homeless women, a fact that has received too little attention within the social science literature. This study utilizes data drawn from interviews with homeless women and service providers in Edinburgh, San Francisco, Vancouver, Montreal and Ottawa, to explore the complex survival strategies that homeless women develop to prevent criminal victimization. Through women's words, we see that gender is understood strategically as performance. Four gender performances are identified and discussed: the ‘femininity simulacrum’, the ‘masculinity simulacrum’, ‘genderlessness’ and ‘passing’. We discussed how each of these performances is employed in the pursuit of safety and security in frequently violent and chaotic social spaces.     

Gendered Organizations: Progress and Prospects

In this paper, we explore the context for the emergence of a theory of gendered organizations and define the basic features of the approach, noting the explosion of scholarship in the area and the now firmly established trend toward understanding gender, race, class, and sexuality as aspects of social structures. We focus on three of the most important emerging areas in research on gendered organizations: the study of intersectionality, the increasing emphasis on the importance of organizational context, and the exploration of mechanisms for organizational change. We conclude by briefly noting prospects for the further development of research on gendered organizations.     

Older Carers of Adults with a Learning Disability Confront the Future: Issues and Preferences in Planning

The Valuing People White Paper (Department of Health, 2001)requires services to secure a plan for all service-users withlearning disabilities living with older carers and promisesthem and their families more choice and control over how andwhere they live. This paper examines the views of the oldercarers (aged over seventy) of sixty-two adults with a learningdisability about planning for the future. Fifty-six took partin interviews in their own homes and six completed a questionnaire.All carers were white and recruited from one local authorityin response to the requirements of the White Paper. Findingsindicate that a significant proportion (thirty-four—55per cent) is either not ready or is unwilling to make futureplans. Barriers to planning include a perceived lack of needdue to the existence of two carers, a lack of awareness of timescalesinvolved in securing housing, difficulties in letting go, alack of confidence in available housing options, and the existenceof mutually supportive relationships. The findings show a needfor a proactive approach to information and support provisionto enable these families to work through a process of makingplans for the future. This is essential to prevent the needfor emergency placements in response to crisis and in turn toensure that adults with learning disabilities have genuine choiceand involvement in how and where they live.