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401.
AbstractAt a time when public debates about radicalization of Muslim youth in the West are taking center stage and when questions about “home-grown” security threats are increasing in the wake of a number of terrorist attacks in many émigré societies, this article provides fresh empirical insights from the perspective of religious leadership. It outlines a picture of a highly diverse Muslim religious landscape where competing religious discourses are struggling to attract and support Muslim youth facing social dislocation and identity crises within increasingly contested social milieus. The article argues that a typology of religious leadership is clearly emerging where a spectrum of faith-based orientations and religious practice emphasize, to different degrees, notions of attachment to universal ethics and individual agency. The fact that conservative, sometimes radical, interpretations of such contestations represent a minority of voices is heartening even though the actual damage by such minority is often disproportionate to its actual size within the so-called silent majority. The empirical insights provided by the religious leaders interviewed for this study offer hope that the future of Western Muslims is more positive than we are led to think, if the possibility of combining devout faith with local political engagement becomes a real and sustainable conduit towards social inclusion and intercultural understanding and if necessary support and understanding are extended by the host communities. 相似文献
402.
Luca Grassano Giulia Ranzato Michele Pellegrini Marco Costantini 《Pharmaceutical statistics》2023,22(3):570-576
Here we present as case study how re-randomization tests were performed in two randomized, controlled clinical trials as sensitivity analyses, as recommended by the United States Food and Drug Administration in the context of adaptive randomization. This was done to confirm primary conclusions on immunological noninferiority of an investigational new fully liquid presentation of a quadrivalent cross-reacting material conjugate meningococcal vaccine (MenACWY-CRM), over its licensed lyophilized/liquid presentation. In two phase 2b studies (Study #1: NCT03652610; Study #2: NCT03433482), noninferiority of the fully liquid presentation of MenACWY-CRM to the licensed presentation was assessed and demonstrated for immune responses against meningococcal serogroup A (MenA), the only vaccine component modified from lyophilized to liquid in the new presentation. The original vaccine assignment algorithm, with a minimization procedure accounting for center or center within age strata, was used to re-randomize participants belonging to the fully liquid and licensed vaccine groups while keeping antibody responses, covariates and entry order as observed. Test statistics under re-randomization were generated according to the ANCOVA model used in the primary analysis. To confirm immunological noninferiority following re-randomization, the corresponding p-values had to be <0.025. For both studies and all primary objective evaluations, the re-randomization p-values were well below 0.025 (0.0004 for Study #1; 0.0001 for the two co-primary endpoints in Study #2). Re-randomization tests performed to comply with a regulatory request confirmed the primary conclusions of immunological noninferiority for the MenA of the fully liquid compared to the licensed vaccine presentation. 相似文献
403.
Nwakerendu Waboso Laurel Donison Rebecca Raby Evan Harding Lindsay C. Sheppard Keely Grossman Haley Myatt Sara Black 《Children & Society》2023,37(1):199-215
Using a relational approach, we draw on repeated interviews with a group of 30 diverse children from Ontario to share and reflect on their knowledge, experiences and feelings early in the COVID-19 pandemic. Prioritising relational interdependence and relational agency, this paper illustrates our participants' embedded engagements with the pandemic and their contribution to the co-production of knowledge. We emphasise their thoughtful responses to the pandemic; their creative, self-reflexive strategies for managing a difficult time; and their advice to others. We thus prioritise children's viewpoints and emphasise their relational interconnections with others during a time that was marked by social isolation. 相似文献
404.
Michele Lalla 《LABOUR》1995,9(3):481-506
ABSTRACT: The procedure used to analyse a data set which includes only censored or incomplete spells is examined in this paper. First of all, the distributions of incomplete spell durations are analysed without explanatory variables (such as age, gender, and so on), assuming that unobserved completed spells have a Weibull distribution. The relationships between the mean of the incomplete spells and the mean of the completed spells are reported for first-job seekers, unemployed, employed and self-employed workers. Given that the unobserved completed spells are Weibull-distributed, the unobserved heterogeneity is introduced on the scale parameter of the Weibull. The heterogeneity, considered as a variable, is analysed for a binomial or Weibull distribution. As the beginning of a spell is a retrospective datum, the recall errors are modelled including the heaping effect. Using some proportional hazards models, the methodology to study the influences of explanatory variables on spell distributions is then described, once again including both the heterogeneity and the heaping effect. On this basis, the lengths of on-going spells of unemployment for first-job seekers and unemployed workers are modelled, as well as the current job tenures of employed and self-employed workers. 相似文献