Cocaine use among the College Age Group: Biological and Psychological Effects—Clinical and Laboratory Research Findings

Abstract

Though cocaine has been used by man for centuries for both medical and nonmedical reasons, a knowledge of its effect on the human mind and body remains limited and not yet clearly documented. Sources of information consist of myth, street knowledge, animal studies, and clinical and laboratory studies of man. This paper focuses on findings from the latter two sources.

The biological effects of cocaine include the local effects of producing anesthesia and constriction of blood vessels in areas where it is applied topically. Solutions of the drug applied directly to the eye cause the pupils to dilate. Systemic effects include an increase in heart rate and blood pressure. In some individuals, an increase in alertness occurs, and in others a state of drowsiness. The drug also decreases total sleep, REM sleep, and appetite.

The psychological effects of the drug vary with dosage, chronicity, and a host of other variables. Increasing doses over long periods of time appear to cause increasingly severe impairment of affective and cognitive functioning. These effects include a strong psychological craving, making cocaine one of the most powerfully reinforcing of all known substances. In addition, cocaine may induce symptoms ranging from mild euphoria to hyperalertness, hyperactivity, anorexia, insomnia, hypersexuality, and proneness to violence. In others, cocaine may produce sadness, melancholia, apathy, and various symptoms of dysphoria. Depression has been reported to occur in people who stop taking the drug, especially those who have taken the drug intravenously. At high doses taken over a long period of time, cocaine may produce symptoms that mimic acute paranoid psychosis with hallucinations, stereotyped behavior, paranoid delusions, insomnia, and proneness to violence. Finally, cocaine may cause delirium, convulsions, and death from cardiorespiratory failure. With over 30 million individuals in the college age group reported to have taken cocaine, college health personnel must be prepared to diagnose and treat symptoms resulting from cocaine toxicity.     

An Application of Response Surface Methodology to the Atari® Miniature Golf Video Game

Response surface methodology is used to optimize a player's performance on the Atari® Miniature Golf computer video game. Because of the nature of the fitted response surface, a direct optimization procedure is used to estimate the optimum operating conditions.     

Inference on treatment effects for targeted clinical trials under enrichment design

After completion of a human genome project, the disease targets at molecular level can be identified. As a result, treatment modality for molecular targets can be developed. In practice, targeted clinical trials are usually conducted for evaluation of the possibility and feasibility of the individualized treatment of patients. However, the accuracy of diagnostic devices for identification of such molecular targets is usually not perfect. Therefore, some of the patients enrolled in targeted clinical trials with a positive result by the diagnostic device might not have the specific molecular targets and hence the treatment effects of the targeted drugs estimated from targeted clinical trials could be biased for the patient population truly with the molecular targets. Under an enrichment design for targeted clinical trials, we propose to use the EM algorithm and bootstrap method for obtaining the inference of the treatment effects of the targeted drugs in the patient population truly with molecular targets. A simulation study was conducted to empirically investigate the bias and variability of the proposed estimator and the size and power of the proposed testing method. Simulation results demonstrate that the proposed estimator is unbiased with adequate precision and the confidence interval can provide satisfactory coverage probability. In addition, the proposed testing procedure can adequately control the size with sufficient power. A practical example illustrates the utility of the proposed method. Copyright © 2009 John Wiley & Sons, Ltd.     

现代经济理论的失败:建设性后现代思想家看全球金融危机——柯布博士访谈录

目前,美国已陷入20世纪30年代经济大崩溃以来最严重的一次金融危机。从房市泡沫破裂、次贷危机、油价与物价上涨、经济衰退到一系列大公司倒闭,一连串的人为因素造成了华尔街哀鸿遍野的败象。那么,是什么原因导致了这次美国金融危机的爆发呢?应《文史哲》杂志的邀约,带着这个问题,利用世界著名建设性后现代思想家,美国著名生态经济学家,中美后现代发展研究院院长柯布博士(JohnB.Cobb,Jr.)参加中央编译局和中美后现代发展研究院在美国克莱蒙举办的"马克思主义与生态文明国际学术研讨会"的宝贵机会,美国《世界文化论坛》报主编樊美筠博士专门采访了柯布博士。在访谈中,柯布博士从建设性后现代主义视角对当前这场金融危机进行了诊断。他精辟地指出,此次金融危机实际上宣告了现代西方经济理论特别是风靡一时的新自由主义经济学的失败,因为它是建立在现代机械哲学和个人主义之上的。他明确预言:"美国作为世界经济中心的日子正在飞快地走向终结。"并向世人发出了预警:"美国在不久的将来会成为危险的敌人",至少"它不会是一个很可靠的朋友"。     

A partnership forged: BSW students and service learning at a historically Black college and university (HBCU) serving urban communities

ABSTRACT

Historically Black colleges and universities (HBCUs) have a long-standing history of engaging the African-American community. In most instances, these institutions are located in predominantly African-American communities. This article intends to offer a discussion of a pedagogical approach used at an HBCU, located in a large mid-Atlantic city. The purpose of this macro-assignment was an effort designed to prepare BSW students for macro-practice with communities through participation in service-learning projects that involved community engagement with urban communities. Outcomes reflect that students have a vested interest in working with underserved communities, which exemplifies the School of Social Work’s mission; said mission is to fully prepare urban social work leaders who are committed to the alleviation of human suffering, social justice, and the improvement of the quality of life for diverse urban populations.     

Cosmopolitism and Localism in the Brazilian Social Sciences

This article analyzes the main trends of sociology and political science in Brazil. It uses as empirical data the workgroups and the bibliographical reviews sponsored by the Associação Nacional de Pós‐Graduação e Pesquisa em Ciências Sociais (ANPOCS), a scientific association that organizes much of the debate in the Brazilian social sciences in the last 40 years. From these data, it is verified that sociology and political science in Brazil combine a universalist vocation, in relation to its themes and problems, with an almost exclusive focus on Brazilian society. It is also considered that the current coup d'État imposes new interpretative challenges to Brazilian social sciences, which can no longer consider stable or irreversible the process of democratization of society and its political institutions. Cet article analyse les grandes tendances de la sociologie et de la science politique au Brésil. Il se fonde sur des données empiriques venant de groupes de travail et de recensions bibliothécaires sponsorisés par l'Associação Nacional de Pós‐Graduação e Pesquisa em Ciências Sociais (ANPOCS), une association scientifique qui a organisé la plupart des débats dans les sciences sociales brésiliennes au cours des 40 dernières années. Il en découle que la sociologie et la science politique au Brésil combinent une vocation universelle, en relation avec ses thèmes et ses problèmes, et un focus presqu'exclusivement centré sur la société brésilienne. Il est aussi démontré que le coup d'État en court impose de nouveaux défis interprétatifs dans les sciences sociales brésiliennes, qui ne peuvent plus considérer le processus de démocratisation de la société et de ses institutions politiques comme étant stables ou irréversibles.     

The space center at Colorado Springs

In the early 1980s, the Department of Defense located a fifth major installation near Colorado Springs: the Consolidated Space Operations Center. With four major facilities, contractors, and research and development firms, the city was already saturated with defense installations. Socioeconomic impact analysis would have to be different than for either defense or energy development. Planners collected data on local businesses, defense contractors, and military households. They found that indirect spending would be considerably lower than from a corresponding amount of private sector spending. Also, the military population would not grow in an intergenerational sense because its high mobility tends to inflate population projections if not adjusted.     

Bayesian inference for smooth transition autoregressive (STAR) model: A prior sensitivity analysis

The main aim of this paper is to perform sensitivity analysis to the specification of prior distributions in a Bayesian analysis setting of STAR models. To achieve this aim, the joint posterior distribution of model order, coefficient, and implicit parameters in the logistic STAR model is first being presented. The conditional posterior distributions are then shown, followed by the design of a posterior simulator using a combination of Metropolis-Hastings, Gibbs Sampler, RJMCMC, and Multiple Try Metropolis algorithms, respectively. Following this, simulation studies and a case study on the prior sensitivity for the implicit parameters are being detailed at the end.     

Defining public relations roles in the U.S.A. using cluster analysis

This exploratory study attempted to discover key public relations (PR) practitioner roles through a survey design using factor-cluster analysis. The Public Relations Society of America (PRSA) partnered with the researchers by inviting PRSA members to complete a survey in which 256 members participated. Although different items were used, the results of this study were similar to the findings of a study conducted on European PR practitioners by Beurer-Zullig, Fieseler, and Meckel (2009) thus suggesting concurrent validity. Five PR roles were found incorporating personal characteristics, modes of communication, management and technical functions, perceived level of respondent strategic planning process involvement, and attitudes about communication goals and PR measurement (including perceived competency). The roles were labeled negotiator, policy advisor, brand officer, internal communicator, and press agent. The negotiator and policy advisor roles, which were management positions, viewed measurement research as important in the practice of PR.     

Voluntary After‐School Alcohol and Drug Programs for Middle School Youth: If You Build it Right,They Will Come

Few after‐school programs target alcohol and other drug (AOD) use because it is difficult to encourage a diverse group of youth to voluntarily attend. The current study describes CHOICE, a voluntary after‐school program which targeted AOD use among middle school students. Over 4,000 students across eight schools completed surveys and 15% participated in CHOICE. Analyses indicated that there were some differences between CHOICE participants and nonparticipants. For example, African American and multiethnic students were more likely to attend. Past month alcohol users were more likely to initially attend, and marijuana users were more likely to continue attendance. Thus, CHOICE reached students of different racial and ethnic groups and attracted higher risk youth who may not typically obtain prevention services.