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61.
Renata Gabriel Fontinele Eliane Florencio Gama Renata de Brito Mari Romeu Rodrigues de Souza André Conrado 《The aging male》2017,20(3):161-167
This study aimed to analyze the effects of caloric restriction on aged femoral articular cartilage of Wistar rats. Three groups of eight animals each were considered: young (YC) and old (OC) control groups fed with a normal diet and old caloric restriction group (OCR) composed of 18-month-old animals fed with a 31% less caloric diet from 6-months of age. Articular cartilage was studied through morphometry and immunohistochemistry. Body mass was 12% less in the OCR group than in the OC group. The articular cartilage from OC rats show thinner medial condyles, fewer chondrocytes, smaller chondrocytes nuclear volume and, in both condyles, a predominance of collagen type II and less collagen density compared to both YC and OCR groups (p?.001). In contrast, OCR articular cartilage show thicker medial condyles, larger chondrocytes nuclear volume and increased collagen density compared to OC group (p?0.001). We concluded that caloric restriction minimizes the effects of aging on medial condyles of the femoral articular cartilage. 相似文献
62.
Upper and lower bounds are obtained for the mean of the negative binomial distribution. These bounds are simple functions of a percentile determined by the shape parameter. The result is then used to obtain a robust estimate of the mean when the shape parameter is known. 相似文献
63.
We consider the situation in which a buying organization deals with a discrete quantity discount schedule offered by a selling organization. Furthermore, the buying organization can negotiate with the selling organization about the lot size and purchase price, but does not know the underlying function that was used by the selling organization to determine the quantity discount schedule. In this paper, we provide an analytical and empirical basis for one general quantity discount function (QDF) that can be used to describe the underlying function of almost all different quantity discount types. We first develop such a QDF analytically. Among other things, this QDF enables buying organizations to calculate detailed prices for a large number of quantities. We subsequently show that the QDF fits very well with 66 discount schedules found in practice. We discuss that the QDF and related indicators can be a useful tool in supplier selection and negotiation processes. It can also be used for competitive analyses, multiple sourcing decisions, and allocating savings for purchasing groups. Additionally, the QDF can be included in research models incorporating quantity discounts. We conclude the paper with an outlook on further QDF research regarding the characterization of commodity markets from a demand elasticity point of view. 相似文献
64.
65.
Ronald de Korte RA RE RO CIA Gert van der Pijl RE 《Journal of Management and Governance》2009,13(1-2):5-40
Purpose The purpose of the paper is to present a theory of organisational change within the setting of a governmental bureaucracy. Design/methodology/approach Orthodox grounded theory is employed in the setting of a change programme in 12 Audit departments of the Dutch Ministries (public-sector). Findings The examined organisational change has specific characteristics. The Dutch ‘ministerial autonomy’ and the clearly recognizable role types of the key figures involved have a strong impact on the change programme and the realisation of its goals. Research limitations/implications Findings are derived on the basis of a substantive case study of the change programme of the Dutch Departmental Audit function. The research sheds new light on characteristics related to the occupational group of Chartered Accountants and characteristics of a governmental bureaucracy and it helps to understand change programmes within this bureaucracy. Practical implications The grounded theoretical model draws attention to the impact of key figures and circumstances on a change programme within the central government. Originality/value The paper builds on theories of organisational change but applies them in the typical context of the Dutch civil service where ministerial autonomy, on the one hand, and a move in the direction of more centrally organised activities (concern idea), on the other, require a difficult balancing act of all players in the change arena. 相似文献
66.
Riccardo Borgoni Valeria Tritto Daniela de Bartolo 《Journal of applied statistics》2013,40(9):2069-2086
Radon is a naturally occurring decay product of uranium known to be the main contributor to natural background radiation exposure. It has been established that the health risk related to radon exposure is lung cancer. In fact, radon is considered to be a major leading cause of lung cancer, second only to smoking. In this paper, we identified building typologies that affect the probability of detecting indoor radon concentration above reference values, using the data collected within two monitoring campaigns recently conducted in Northern Italy. This information is fundamental both in prevention, i.e. when the construction of a new building is planned and in mitigation, i.e. when a high concentration detected inside buildings has to be reduced. A spatial regression approach for binary data was adopted for this goal where some relevant covariates on the soil were retrieved by linking external spatial databases. 相似文献
67.
Alan T. Peacock 《Population studies》2013,67(3):298-305
The persistence of the population problem in many developing countries' especially in Asia, must mean that the relation between population trends and productivity has to be kept continually under review. In recent years the economists' interest in this relation has shifted away from the Keynesian stagnation analysis, with its emphasis on the influence of population trends on the level and composition of consumption and investment, to a reconsideration of their influence on production. It is a striking testimony to the influence of Malthus that his theory is still under active consideration and that it frequently serves as starting point, as it does for Professor Belshaw, for an analysis of the economics of population. Divorced from its particular context, in which value judgements particularly distasteful to many commentators abound, and reformulated in terms of modern production theory, it clarifies the main issues, by showing what facts are required and what logic demands in order to provide a useful answer to practical problems of policy. Readers of the first two chapters of Professor Buquet's book will find ample confirmation of the sterility of much of the debate regarding optimum populations which developed largely from differences of opinion about definitions of “good” and “bad” economic criteria for policy than from faults in logic. The debate continues and the posthumous career of Parson Malthus still occasions even personal abuse! It would be difficult, however, to accuse Professor Belshaw of taking sides in the Malthusian debate. He takes the Malthusian analysis for what it is worth, shows where it fits the facts and where it does not, provides convincing evidence of a Malthusian problem in Asia by a skilful round-up of well presented statistics, and then, instead of committing himself to a forecast of what is likely to happen in Asia, he illustrates through the modern theory of production what are the pre-conditions for a removal of the population problem. This is surely a sensible procedure and contrasts favourably with the sibylline utterances of a number of distinguished amateur social scientists. 相似文献
68.
Alan M. Schwitzer PhD Lee Ellen Rodriguez MS Celeste Thomas MS Lamieh Salimi PhD 《Journal of American college health : J of ACH》2013,61(4):157-166
Abstract The authors examined a proposed profile of eating-related behaviors, associated features, developmental issues, and help-seeking behavior among college women, using an eating disorder response program. The most common symptom scenario was a pattern of regular binge eating, together with daily exercise and occasional purging. The most common associated features were distressing or dysfunctional overconcern about body image and self-esteem, usually with day-to-day stress and intermittent depression. The women who fit this pattern also presented developmental issues of perfectionism, conflictual relationships with parents, and struggles for independence; and they tended to be ambivalent about seeking services. Implications for practice, including the need to develop a framework for eating disorder responses on campus that includes preventive programs and developmental interventions to target emerging and moderate concerns are discussed; limitations and the preliminary nature of the findings are explicated. 相似文献
69.
Kate de Medeiros Robert L. Rubinstein Chiadi U. Onyike Deirdre M. Johnston Alva Baker Matthew McNabney 《Journal of Housing for the Elderly》2013,27(1-2):206-220
We compared data drawn from a random sample of 399 current assisted living residents and a subsample of 222 newly admitted residents for two groups: childless residents and residents with children. The percentage of childless residents (26%) in our study was slightly higher than U.S. population estimates of childless individuals aged 65 years and older (20%). In the overall sample, the two groups differed significantly by age, race, and women's years of education. The childless group was slightly younger, had a higher percentage of African American residents, and had more years of education than the group with children. In the subsample, we looked at demographic, functional, financial, and social characteristics and found that childless residents reported fewer diagnoses of dementia and fewer visits from a relative but more reported paying less money per month for assisted living and having private insurance than residents with children. As childlessness among older adults continues to increase, it will become increasingly important to understand how child status affects the need for and experience of long-term care. 相似文献
70.
Youssef Azghari Erna Hooghiemstra Fons J. R. van de Vijver 《Journal of Muslim Minority Affairs》2015,35(2):280-295
AbstractWe examined to what extent Moroccan-Dutch (N?=?25) between 15 and 32 years of age are oriented towards the Dutch and Moroccan community when describing their identities. We used the Twenty Statements Test (developed by Kuhn and McPartland (1954). See, M. H. Kuhn and T. S. McPartland, “An Empirical Investigation of Self-attitudes”, American Sociological Review, Vol. 19, No. 1, 1954, p. 69. In this study, participants were asked to complete the sentence with ‘I am..’ 20 times to assess how they described themselves.) and in-depth interviews to understand their challenges on the acculturation path since many face disadvantage and exclusion in the Dutch community. Moroccan-Dutch were, compared to the reference groups of mainstream Dutch (N?=?20) and Moroccans (N?=?25), more proud of their ethnic identity and attached to Islam. Though their Dutch language was dominant, they felt more Moroccan. They praised the Dutch openness, but suffered from negative stereotyping. Their participation in the Dutch community was low. To enhance their position, social professionals working with Moroccan-Dutch could draw on the rich ethnic and faith traditions of this group to encourage their deeper engagement with the Dutch society. 相似文献