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121.
Two-stage designs offer substantial advantages for early phase II studies. The interim analysis following the first stage allows the study to be stopped for futility, or more positively, it might lead to early progression to the trials needed for late phase II and phase III. If the study is to continue to its second stage, then there is an opportunity for a revision of the total sample size. Two-stage designs have been implemented widely in oncology studies in which there is a single treatment arm and patient responses are binary. In this paper the case of two-arm comparative studies in which responses are quantitative is considered. This setting is common in therapeutic areas other than oncology. It will be assumed that observations are normally distributed, but that there is some doubt concerning their standard deviation, motivating the need for sample size review. The work reported has been motivated by a study in diabetic neuropathic pain, and the development of the design for that trial is described in detail. 相似文献
122.
Joshua R. Goldstein Tomáš Sobotka Aiva Jasilioniene 《Population and development review》2009,35(4):663-699
Total fertility rates fell to previously unseen levels in a large number of countries beginning in the early 1990s. The persistence of TFRs below 1.3 raised the possibility of rapid population aging and decline. We discuss the recent widespread turnaround in so‐called lowest‐low‐fertility countries in Europe and East Asia. The number of countries with TFRs below 1.3 fell from 21 in 2003 to five in 2008. Moreover, the upturn in the TFR was not confined to lowest‐fertility countries, but affected the whole developed world. We explore the demographic explanations for the recent rise in TFRs stemming from fertility timing effects as well as economic, policy, and social factors. Although the current economic downturn may suppress TFRs in the short run, we conclude that formerly lowest‐low‐fertility countries will continue to see increases in fertility as the transitory effects of shifts to later childbearing become less important. 相似文献
123.
Contemporary global issues can be examined through the lens of modern photographic art. In an effort to prepare global-ready graduates, this article explores the pressing problems of environmental degradation, urbanization, and homelessness through the work of three contemporary artists. Illustrative works, suggested approaches, and curriculum resources are provided. 相似文献
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125.
This comparative social-historical study examines different versions of state-socialist body politics manifested in Hungary and Slovenia mainly during the 1950s by using archive material of “unnatural fornication” court cases. By analyzing the available Hungarian “természet elleni fajtalanság” and Slovenian “nenaravno ob?evanje” court cases, we can shed light on how the defendants were treated by the police and the judiciary. On the basis of these archive data that have never been examined before from these angles, we can construct an at least partial picture of the practices and consequences of state surveillance of same-sex-attracted men during state-socialism. The article explores the functioning of state-socialist social control mechanisms directed at nonnormative sexualities that had long-lasting consequences on the social representation of homosexuality in both countries. 相似文献
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127.
Gibrán Cruz-Martínez 《Social indicators research》2017,134(3):955-979
Several scholars have confirmed the role that the welfare state (WS) plays in reducing poverty, promoting equality and ensuring the common wellbeing. One of the limitations of the scholarship has been the conceptualization and operationalization of the WS and poverty as one-dimensional variables. The purpose of this paper is to examine the relationship between welfare state development, single-dimensions deprivations and income inequality in Latin America and the Caribbean, before and after controlling for demographic and cyclical factors. The WS is operationalized as a one-dimensional variable, but also taking into account its multidimensional nature. Three individual deprivations suffered by people on poverty and two income inequality indicators are used as dependent variables. Three pooled time-series cross-section regression analyses with panel-corrected standard errors models were carried out on 18 countries in the region around 2000, 2005 and 2010. This paper shows that the development of social-welfare programs and institutions seems to be an effective way of tackling individual deprivations suffered by people on poverty in the region. On the other hand, the WS development didn’t appear to be effective to reduce income inequality. The outcomes of welfare institutions appear to be the pivotal dimension to reduce income inequality and income deprivations in the region. 相似文献
128.
Dolores Moreno-Herrero Manuel Salas-Velasco José Sánchez-Campillo 《Journal of Family and Economic Issues》2017,38(4):596-613
Understanding the motives that underlie Spaniards’ retirement saving decisions is important because many, if not most, future retirees will need to rely on personal savings to maintain a decent standard of living. The governor of the Bank of Spain has stated recently that the current public pension system will not guarantee an adequate pension to the citizens, advising to save now for retirement. In this debate on public pensions, and the complementary role that private pensions might play in Spain, this article has shed light on the decision of Spanish households to engage in individual pension plans and it has identified which factors determine the total amount saved in such retirement plans. Using micro data from the Bank of Spain (Survey of Household Finances 2011), the analysis has revealed that the expectations of lower future income, along with preferences for the financial risk and education, exert an important influence on the likelihood of enrolling in a private pension plan. University education minimizes the myopic behavior of households in the sense of making them more forward-looking and cautious in the face of their future well-being. Additionally using Heckman’s methodology to correct for the problem of selection bias, our results have revealed that liquidity constraints affect negatively the total amount of money saved for retirement. 相似文献
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130.
The urban domestic gardens that are part of urban green areas have become a very important element due to their ecosystematic benefits and the poor information about them. Information regarding the floristic richness of three socioeconomic stratifications from the city of Heredia, Costa Rica is presented in this study. Research was conducted from October 2011 to May 2012. Information was collected using a semi-structured questionnaire, which was provided to 61 garden owners, including the owner’s personal data, time living in the dwelling, area of the property and the garden, variation of its size in time and the garden’s location on the property. In addition, a floristic inventory was conducted in each garden as well as a taxonomic identification of all plants. Vegetative forms and substrates were also noted. Characteristics of the gardens and their owners were then analyzed to determine the relationship of species richness between the three sites studied. The number of plant species recorded was 618, corresponding to 102 families (19 % exotic). Regarding geographical origin, 64, 4 % were exotic, 35,6 % native. Orchidaceae (93 spp.) and Araceae (39 spp.) were the most dominant families. The variables of garden area and location and owner's age determined the garden’s floristic richness. In addition, the garden’s area and vegetative forms varied among the sites studied probably due to socioeconomic differences among them. Diversity of pioneer plants increased with the garden’s area. In sum, this research provides important floristic information of domestic gardens, since, being private property, data about them is scarce and municipal management guidelines are nonexistent. 相似文献