Targeting the role of the endosome in the pathophysiology of Alzheimer's disease: a strategy for treatment

Membrane-bound endosomal vesicles play an integral role in multiple cellular events, including protein processing and turnover, and often critically regulate the cell-surface availability of receptors and other plasma membrane proteins in many different cell types. Neurons are no exception, being dependent on endosomal function for housekeeping and synaptic events. Growing evidence suggests a link between neuronal endosomal function and Alzheimer's disease (AD) pathophysiology. Endosomal abnormalities invariably occur within neurons in AD brains, and endocytic compartments are one likely site for the production of the pathogenic beta-amyloid peptide (Abeta), which accumulates within the brain during the disease and is generated by proteolytic processing of the amyloid precursor protein (APP). The enzymes and events involved in APP processing are appealing targets for therapeutic agents aimed at slowing or reversing the pathogenesis of AD. The neuronal endosome may well prove to be the intracellular site of action for inhibitors of beta-amyloidogenic APP processing. We present here the view that knowledge of the endosomal system in the disease can guide drug discovery of AD therapeutic agents.     

Using Analysis of Variance and Factor Analysis for the Reduction of High Dimensional Variation in Time Series of Energy Consumption

Summary: In this paper the complexity of high dimensional data with cyclical variation is reduced using analysis of variance and factor analysis. It is shown that the prediction of a small number of main cyclical factors is more useful than forecasting all the time-points separately as it is usually done by seasonal time series models. To give an example for this approach we analyze the electricity demand per quarter of an hour of industrial customers in Germany. The necessity of such predictions results from the liberalization of the German electricity market in 1998 due to legal requirements of the EC in 1996.     

Parents, Politics and the Public Purse: activists in the special education arena in Germany

Using a 'social interest' approach, this paper details the advocacy strategies of parents of children with disabilities in the Federal Republic of Germany during the 1980s. Parents developed grass-roots organizations beginning in the 1970s in the former West Germany in response to the stigma and isolation of the well-developed system of Sonderschulen (special schools). Parent groups described here include both those with children already in the Sonderschulen working to ensure its promise of special help for their children and those working to bypass the Sonderschule system by establishing model integration programs in the general schools. The collective actions that led to local successes for both these parent advocate approaches are documented, but so, too, are the obstacles the parents encountered in the broader political arena. Politicians continue to cite limited education budgets, especially following the unification of the two Germanys, and they also raise concerns which some parents share: that significant expansion of special educational support into the general schools could undermine the viability of the Sonderschulen . Thus, one political response to the integration movement has been to find places for some children with disabilities in the general schools, but accompanied by only minimal special education support.     

The Development of a Physician Vitality Program: A Brief Report

We describe the development of an innovative program to support physician vitality. We provide the context and process of program delivery which includes a number of experimental support programs. We discuss a model for intervention and methods used to enhance physician resilience, support work‐life balance, and change the culture to one that explicitly addresses the physician's biopsychosocial‐spiritual needs. Recommendations are given for marriage and family therapists (MFTs) who wish to develop similar support programs for healthcare providers. Video Abstract     

Gender Differences in Heterosexual College Students' Conceptualizations and Indicators of Sexual Consent: Implications for Contemporary Sexual Assault Prevention Education

Because sexual assault is often defined in terms of nonconsent, many prevention efforts focus on promoting the clear communication of consent as a mechanism to reduce assault. Yet little research has specifically examined how sexual consent is being conceptualized by heterosexual college students. In this study, 185 Midwestern U.S. college students provided responses to open-ended questions addressing how they define, communicate, and interpret sexual consent and nonconsent. The study aimed to assess how college students define and communicate consent, with particular attention to gender differences in consent. Results indicated no gender differences in defining consent. However, there were significant differences in how men and women indicated their own consent and nonconsent, with women reporting more verbal strategies than men and men reporting more nonverbal strategies than women, and in how they interpreted their partner's consent and nonconsent, with men relying more on nonverbal indicators of consent than women. Such gender differences may help to explain some misunderstandings or misinterpretations of consent or agreement to engage in sexual activity, which could partially contribute to the occurrence of acquaintance rape; thus, a better understanding of consent has important implications for developing sexual assault prevention initiatives.     

Reports of Conferences,Institutes, and Seminars

A busy time for librarians was late May through early July 2008 with the Ohio Valley Group of Technical Services Librarians meeting May 14–16, the North American Serials Interest Group meeting June 5–8, and an American Library Association preconference Electronic Serials 101: What I Wished I’d Known Before I Got in Over My Head, June 27.     

Building ‘community’ for different stages of life: physical and social infrastructure in master planned communities

As cities around the world struggle to cope with increasing populations, major new master planned housing developments are being undertaken to meet the demand for housing. Such urban developments are influencing workforce, household, and community relations, which in turn drive health and well-being outcomes, and affect social capital and labour market participation. This paper reports findings from the first phase of data collection for the Work, Home and Community Project. Fourteen focus groups were conducted with 68 men and women who live and/or work at newly developed master planned communities in South Australia and Victoria. Findings indicate that familiarity, availability, and the enabling of social bridges contribute to the development of community and social capital in these residential areas. For individuals at different stages of life these factors were facilitated or inhibited by specific physical and social infrastructures in the residential area and the workplace. At a time when concerns are being raised about the ability of people to combine work, home, and community these findings shed some light on the physical and social infrastructures that can enable or constrain the building of healthy communities.