The Family Team at Boston Healthcare for the Homeless Program: an integrated approach to care in outreach settings

Since 1986, the Family Team at Boston Health Care for the Homeless Program has implemented an integrated, inter-professional, team-based model of care to serve families experiencing homelessness. The Family Team employs key strategies delineated by the well-established Health Care for the Homeless model, which emphasizes the importance of outreach medicine and a case management “one-stop shop approach”. We include an account of a specific case where the Family Team’s unique model helped a refugee family in Massachusetts access medical and social services otherwise more difficult to obtain. The Family Team’s onsite presence in the hotel-shelter and the team-based approach facilitated diagnosis of and successful treatment for cervical cancer in a mother of eight children. This case report suggests that the Health Care for the Homeless model of care should be more widely adopted in order to best serve homeless families.

Abbreviations: Boston Health Care for the Homeless Program (BHCHP); Emergency Assistance (EA); Health Care for the Homeless (HCH); Massachusetts General Hospital (MGH)     

A NEW APPROACH TO DISCRIMINATION AND CLASSIFICATION USING A HAUSDORFF TYPE DISTANCE

A new method of discrimination and classification based on a Hausdorff type distance is proposed. In two groups, the Hausdorff distance is defined as the sum of the furthest distance of the nearest elements of one set to another. This distance has some useful properties and is exploited in developing a discriminant criterion between individual objects belonging to two groups based on a finite number of classification variables. The discrimination criterion is generalized to more than two groups in a couple of ways. Several data sets are analysed and their classification accuracy is compared to that obtained from linear discriminant function and the results are encouraging. The method in simple, lends itself to parallel computation and imposes less stringent conditions on the data.     

A new extension strategy on three-level factorials under wrap-around L2-discrepancy

Sequential experiment is an indispensable strategy and is applied immensely to various fields of science and engineering. In such experiments, it is desirable that a given design should retain the properties as much as possible when few runs are added to it. The designs based on sequential experiment strategy are called extended designs. In this paper, we have studied theoretical properties of such experimental strategies using uniformity measure. We have also derived a lower bound of extended designs under wrap-around L₂-discrepancy measure. Moreover, we have provided an algorithm to construct uniform (or nearly uniform) extended designs. For ease of understanding, some examples are also presented and a lot of sequential strategies for a 27-run original design are tabulated for practice.     

Multivariate Bayesian U-type asymmetric designs for non parametric response surface prediction under correlated errors

The objective of this paper is to study U-type designs for Bayesian non parametric response surface prediction under correlated errors. The asymptotic Bayes criterion is developed in terms of the asymptotic approach of Mitchell et al. (1994 Mitchell, T., Sacks, J., Ylvisaker, D. (1994). Asymptotic Bayes criteria for nonparametric response surface design. Ann. Stat. 22:634–651.[Crossref], [Web of Science ®] , [Google Scholar]) for a more general covariance kernel proposed by Chatterjee and Qin (2011 Chatterjee, K., Qin, H. (2011). Generalized discrete discrepancy and its applications in experimental designs. J. Stat. Plann. Inference 141:951–960.[Crossref], [Web of Science ®] , [Google Scholar]). A relationship between the asymptotic Bayes criterion and other criteria, such as orthogonality and aberration, is then developed. A lower bound for the criterion is also obtained, and numerical results show that this lower bound is tight. The established results generalize those of Yue et al. (2011 Yue, R.X., Qin, H., Chatterjee, K. (2011). Optimal U-type design for Bayesian nonparametric multiresponse prediction. J. Stat. Plann. Inference 141:2472–2479.[Crossref], [Web of Science ®] , [Google Scholar]) from symmetrical case to asymmetrical U-type designs.     

Estimation of misclassification probabilities by bootstrap methods

Several methods have been proposed to estimate the misclassification probabilities when a linear discriminant function is used to classify an observation into one of several populations. We describe the application of bootstrap sampling to the above problem. The proposed method has the advantage of not only furnishing the estimates of misclassification probabilities but also provides an estimate of the standard error of estimate. The method is illustrated by a small simulation experiment. It is then applied to three published, well accessible data sets, which are typical of large, medium and small data sets encountered in practice.     

Testing in semiparametric models with interaction, with applications to gene–environment interactions

Summary.  Motivated from the problem of testing for genetic effects on complex traits in the presence of gene–environment interaction, we develop score tests in general semiparametric regression problems that involves Tukey style 1 degree-of-freedom form of interaction between parametrically and non-parametrically modelled covariates. We find that the score test in this type of model, as recently developed by Chatterjee and co-workers in the fully parametric setting, is biased and requires undersmoothing to be valid in the presence of non-parametric components. Moreover, in the presence of repeated outcomes, the asymptotic distribution of the score test depends on the estimation of functions which are defined as solutions of integral equations, making implementation difficult and computationally taxing. We develop profiled score statistics which are unbiased and asymptotically efficient and can be performed by using standard bandwidth selection methods. In addition, to overcome the difficulty of solving functional equations, we give easy interpretations of the target functions, which in turn allow us to develop estimation procedures that can be easily implemented by using standard computational methods. We present simulation studies to evaluate type I error and power of the method proposed compared with a naive test that does not consider interaction. Finally, we illustrate our methodology by analysing data from a case–control study of colorectal adenoma that was designed to investigate the association between colorectal adenoma and the candidate gene NAT2 in relation to smoking history.     

A Data-Analytic Look at Skewness and Elongation in Common-Stock-Return Distributions

This article explores the nature of skewness and elongation in daily common-stock-return distributions of individual firms using estimates of g (for skewness) and h (for elongation) obtained from Tukey's g and h distributions. Both parametric and nonparametric (bootstrap) estimates of standard errors of the g estimates are computed and compared. Daily return distributions are first examined cross-sectionally over a large sample of firms. The estimates of the skewness parameter exhibit variation across individual firms, but some general trends are evident across industry groups and firm sizes. Return distributions typically seem to be more elongated than the Gaussian distribution. From a time series perspective, both skewness and elongation are persistent in the return distributions of individual firms and vary over a finite range. First-order autocorrelation coefficients of monthly g and h estimates are large and suggest a certain degree of predictability.     

Bayes estimation for exponential distributions with common location parameter and applications to multi-state reliability models

This paper considers the estimation of the stress–strength reliability of a multi-state component or of a multi-state system where its states depend on the ratio of the strength and stress variables through a kernel function. The article presents a Bayesian approach assuming the stress and strength as exponentially distributed with a common location parameter but different scale parameters. We show that the limits of the Bayes estimators of both location and scale parameters under suitable priors are the maximum likelihood estimators as given by Ghosh and Razmpour [15 M. Ghosh and A. Razmpour, Estimation of the common location parameter of several exponentials, Sankhyā, Ser. A 46 (1984), pp. 383–394. [Google Scholar]]. We use the Bayes estimators to determine the multi-state stress–strength reliability of a system having states between 0 and 1. We derive the uniformly minimum variance unbiased estimators of the reliability function. Interval estimation using the bootstrap method is also considered. Under the squared error loss function and linex loss function, risk comparison of the reliability estimators is carried out using extensive simulations.