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451.
Research on the size–job rewards relationship emphasizes extrinsic rewards that are typically more prevalent in large, complex organizations. We examine whether certain intrinsic rewards are more characteristic of small firms and shift the focus from manufacturing industries to professional service (law) firms. We find that small is not entirely beautiful. Smaller firms offer more autonomy but no more challenging work or better coworker relations, whereas larger firms offer lucrative salaries, enhanced benefits, and greater promotional opportunities. Our results challenge the compensating differential explanation whereby large firms offer superior extrinsic rewards to compensate for a shortfall of instrinsic job rewards.  相似文献   
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453.
Non-mixture cure models are derived from a simplified representation of the biological process that takes place after treatment for cancer. These models are intended to represent the time from the end of treatment to the time of first recurrence of the cancer in studies when a proportion of those treated are completely cured. However, for many studies, other start times are more relevant. In a clinical trial, it may be more natural to model the time from randomisation rather than the time from the end of treatment and in an epidemiological study, the time from diagnosis might be more meaningful. Some simulations and two real studies of childhood cancer are presented to show that starting from time of diagnosis or randomisation can affect the estimates of the cure fraction. The susceptibility of different parametric kernels to errors caused by using start times other than the end of treatment is also assessed. Analysing failures on treatment and relapse after completing the treatment as two processes offers a simple way of overcoming many of these problems.  相似文献   
454.
ABSTRACT

This paper explores the implications of representations of places as ‘diverse’, particularly for those who live in them. Arising from an interdisciplinary research project, the paper takes one neighbourhood in Manchester (Cheetham Hill) and explores some of the narratives about it produced by residents and those who have a ‘professional’ stake in the area. These are put in the context of public narratives of the area, as well as Census data. The paper examines how different types of data generate different stories and how different methodological approaches can produce varied understandings of place, which have implications for how a place comes to be known and for the potential impact on the distribution of resources. Cheetham Hill is known as ‘diverse’, or even ‘super-diverse’, but the paper examines how this label serves to obscure lived experience and inequalities and can reveal ambivalences over the ethnic difference and urban living.  相似文献   
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456.
Research on learning patterns of social work students is scare. This longitudinal study addresses this issue by employing mixed methods of quantitative and qualitative study design to understand the learning pattern of students throughout their undergraduate social work studies. Six rounds of quantitative data collected by structured questionnaires and four rounds of qualitative data collected by focus group interviews have been conducted at an interval of every 6 months to track the learning pattern and to evaluate the continuous impacts of social work education on students. Results indicate that although students’ evaluation on the curriculum was positive and with significant difference in mean scores, paired sample t-tests found no significant difference between time 1 and 6 of all outcome variables. With regard to students’ change in attitude, acquisition of knowledge and skills, results indicate a ‘U-shape’ trend and a fluctuating learning pattern with a rebound in different outcome variables toward the end of the three-year study. Qualitative data echoes the findings and reveals that students go through the confused freshman stage, to disillusioned in practicum and finally with enriching experience upon graduation. The paper discusses meanings and implications of student learning pattern to social work education.  相似文献   
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458.
Abstract

Women typically hold jobs in which they experience less pay and less favorable working conditions than men in comparable positions. Despite these differences, women report similar or even higher levels of work satisfaction. Most studies explaining work satisfaction and gender focus on workplace rewards as potential explanatory variables. Little is known about the relevance of support resources from the family domain in relation to women’s and men’s work satisfaction. Finally, the relevance of support resources has not been studied in high-status professions where women have quickly become more highly represented numerically. Using quantitative survey data from a sample of married veterinary doctors (N?=?311), we explore the influence of work and family-based support resources. Specifically, we examine the relationship between work satisfaction and three sources of support: coworkers, family, and spouses. We also explore whether parental status has moderating effects for women and men with these resources in association with work satisfaction. We find that mothers are more satisfied than fathers. Parenthood and supportive family engagement are strong predictors of women’s work satisfaction. Coworker support is a salient predictor of work satisfaction for all, especially for men who are fathers. Implications for men and women working in high-status professions are discussed.  相似文献   
459.
To elucidate cultural contrasts in children's family environments, we conducted in‐depth, direct comparisons of mind‐mindedness and self–other distinction from maternal speech. The study included 5‐min speech samples of 225 mothers from Japan (N = 111) and the U.K. (N = 114) talking about their 3‐ to 6‐year‐old children (including 11 sibling pairs, n = 236). Compared with Japanese mothers, British mothers spoke significantly more, gave a significantly higher proportion of child‐focused and mind‐related comments, and also showed a stronger self–other distinction. In addition, within each country, there was a positive relation between mothers’ references to children in the singular (as opposed to plural) form and their mind‐mindedness. Together, the current findings highlight cultural variations in maternal mind‐mindedness, explicit–implicit communication style, and self–other distinction, and also suggest further exploration of relations among them.  相似文献   
460.
Development of new pharmacological treatments for osteoarthritis that address unmet medical needs in a competitive market place is challenging. Bayesian approaches to trial design offer advantages in defining treatment benefits by addressing clinically relevant magnitude of effects relative to comparators and in optimizing efficiency in analysis. Such advantages are illustrated by a motivating case study, a proof of concept, and dose finding study in patients with osteoarthritis. Patients with osteoarthritis were randomized to receive placebo, celecoxib, or 1 of 4 doses of galcanezumab. Primary outcome measure was change from baseline WOMAC pain after 8 weeks of treatment. Literature review of clinical trials with targeted comparator therapies quantified treatment effects versus placebo. Two success criteria were defined: one to address superiority to placebo with adequate precision and another to ensure a clinically relevant treatment effect. Trial simulations used a Bayesian dose response and longitudinal model. An interim analysis for futility was incorporated. Simulations indicated the study had ≥85% power to detect a 14‐mm improvement and ≤1% risk for a placebo‐like drug to pass. The addition of the second success criterion substantially reduced the risk of an inadequate, weakly efficacious drug proceeding to future development. The study was terminated at the interim analysis due to inadequate analgesic efficacy. A Bayesian approach using probabilistic statements enables clear understanding of success criteria, leading to informed decisions for study conduct. Incorporating an interim analysis can effectively reduce sample size, save resources, and minimize exposure of patients to an inadequate treatment.  相似文献   
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