Physical activity assessment and health outcomes in old age: how valid are dose–response relationships in epidemiologic studies?

In this systematic review the validity of the dose–response relationships between physical activity (PA) and energy expenditure (EE) on defined health outcomes (cardio- and cerebrovascular morbidity and mortality, cancer) for the elderly is questioned. Medline, Cochrane, and EMBASE databases were reviewed for epidemiological longitudinal studies in populations aged 60+ for the years 1985–2007. Although most of the 18 identified studies generally demonstrated an inverse dose–response relationship between PA and EE level with morbidity and mortality, the range of dose–responses was remarkably broad. The nature of the dose–response relationship remained unclear. PA questionnaires - even those constructed for the elderly - do not cover the extremely diverse aspects of age-specific PA behavior and modes of muscular activity. Only non-age-specific tables had been used to estimate the EE in the elderly. Direct measurements of EE were limited. The results have implications for the interpretation of the dose–response relationships between PA and EE on defined health outcomes in old age.     

Validating Grant-Making Processes: Construct Validity of the 2013 Senior Corps RSVP Grant Review

Accountability in grant-making requires a valid, fair and transparent selection process. This study proposes a four-step framework for validating such a process: determine standards for qualified applicants, assess inter-reviewer reliability, assess factorial validity, and assess reliability. This framework is applied to the Corporation for National and Community Service’s 2013 RSVP grant-making process. The standards were close to the highest points of reliability. Inter-reviewer reliability was above 0.90, a common threshold for high-stakes measurement. After conducting confirmatory factor analysis, the final model merged two of the original five domains of selection criteria, resulting in four domains. The final model was found to have strict measurement invariance, high convergent validity, and measurement reliability between 0.88 and 0.93 for all domains. The results validate the 2013 review process and indicated that the scores exhibited high degrees of reliability, giving public assurance that the process was sufficiently objective and accurately reflected program priorities.     

Body Image and Sexuality in Indonesian Adults with a Disorder of Sex Development (DSD)

In Indonesia, disorders of sex development (DSDs) are not well recognized and medical care for affected individuals is scarce. Consequently, many patients live with ambiguous genitalia and appearance. We compared reported outcomes on body image, sexual functioning, and sexual orientation of 39 adults with DSDs (aged 18 to 41) and 39 healthy controls matched for gender, age, and residential setting (urban, suburban, rural). Differences in gender and treatment status (treated or untreated) were also explored. On body image, adults with DSDs reported dissatisfaction with sex-related body parts. Compared to the matched controls, women with DSDs reported greater sexual distress, and men with DSDs reported lower erectile and ejaculation frequencies, and more dissatisfaction with sexual life but not with sexual desire and activities. Men with DSDs who had undergone genital surgery reported higher erectile and ejaculation frequencies than untreated men. More women than men in the DSDs group reported a nonexclusive heterosexual orientation. DSDs and infertility had a great impact on sexuality. Fear of ostracism complicated DSD acceptance. Findings were compared to those of Western studies. Based on these results, education about DSDs and their psychosexual consequences may help reduce the sexual distress and problems in adults with DSDs and improve quality of life.     

Two egalitarian consensus rules

We widen both the domain and codomain of Arrovian social choice, towards respectively profiles of extended orderings and quasi-orderings. We propose, discuss, and characterize two egalitarian consensus rules – a unanimity-leximin and a lexi-unanimity-min rule – which combine the corresponding standard rules in different ways.I would like to thank Bart Capéau, André Decoster, Marc Fleurbaey, Luc Lauwers, Vincent Merlin, Maurice Salles, Erik Schokkaert, Frans Spinnewyn, and Alain Trannoy for stimulating discussions, comments and help. While writing this paper, I also benefitted from my stay at THEMA, Cergy-Pontoise, which was financed by the TMR network Living Standards, Inequality and Taxation [Contract No. ERBFMRXCT 980248] of the European Communities. Errors are mine.     

A statistically adaptive sampling policy to the Hotelling's T2 control chart: Markov chain approach

ABSTRACT

We present an alternative sampling scheme for the Hotelling's T² control chart with variable parameters (VP T²) which allows the sampling interval h, the sample size n, and control limit k to vary between minimum and maximum values while keeping the warning line fixed over time. Our method uses only one measurement scale to overcome the difficulties of using two scales in practice. Later, we demonstrate the merits of the method in terms of its performance in detecting small-to-moderate shifts and its ease of application.     

Bayesian tests for matched proportions

A sample of n subjects is observed in each of two states, S₁-and S₂. In each state, a subject is in one of two conditions, X or Y. Thus, a subject may be recorded as showing a change if its condition in the two states is ‘Y,X’ or ‘X,Y’ and, otherwise, the condition is unchanged. We consider a Bayesian test of the null hypothesis that the probability of an ‘X,Y’ change exceeds that of a ‘Y,X’ change by amount k_O. That is, we develop the posterior distribution of k_O, the difference between the two probabilities and reject the null hypothesis if k lies outside the appropriate posterior probability interval. The performance of the method is assessed by Monte Carlo and other numerical studies and brief tables of exact critical values are presented     

Flight gate scheduling: State-of-the-art and recent developments

This paper surveys a large variety of mathematical models and up-to-date solution techniques developed for solving a general flight gate scheduling problem that deals with assigning different aircraft activities (arrival, departure and intermediate parking) to distinct aircraft stands or gates. The aim of the work is both to present various models and solution techniques which are available in nowadays literature and to give a general idea about new open problems that arise in practise. We restrict the scope of the paper to flight gate management without touching scheduling of ground handling operations.     

Dropout from exercise programs for seniors: a prospective cohort study

This study examines dropout incidence, moment of dropout, and switching behavior in organized exercise programs for seniors in the Netherlands, as determined in a prospective cohort study (with baseline measurements at the start of the exercise program and follow-up after 6 months; N = 1,725, response rate 73%). Participants were community-living individuals 50+ who participated in different forms of organized exercise programs. The average dropout incidence was 0.15 per 6 months, which is lower than that for the general population. The dropout incidence and the timing of dropout differed substantially between the exercise programs. In total, 31% of people who dropped out of one type of exercise program switched to another type of exercise. The type of program and exercise had a strong effect on differences in this switching behavior. It is recommended that switching behavior be monitored in future studies.