Generalized Mann–Whitney Type Tests for Microarray Experiments

New statistical procedures are introduced to analyse typical microRNA expression data sets. For each separate microRNA expression, the null hypothesis to be tested is that there is no difference between the distributions of the expression in different groups. The test statistics are then constructed having certain type of alternatives in mind. To avoid strong (parametric) distributional assumptions, the alternatives are formulated using probabilities of different orders of pairs or triples of observations coming from different groups, and the test statistics are then constructed using corresponding several‐sample U‐statistics, natural estimates of these probabilities. Classical several‐sample rank test statistics, such as the Kruskal–Wallis and Jonckheere–Terpstra tests, are special cases in our approach. Also, as the number of variables (microRNAs) is huge, we confront a serious simultaneous testing problem. Different approaches to control the family‐wise error rate or the false discovery rate are shortly discussed, and it is shown how the Chen–Stein theorem can be used to show that family‐wise error rate can be controlled for cluster‐dependent microRNAs under weak assumptions. The theory is illustrated with an analysis of real data, a microRNA expression data set on Finnish (aggressive and non‐aggressive) prostate cancer patients and their controls.     

Contract Structure,Risk‐Sharing,and Investment Choice

Few microfinance‐funded businesses grow beyond subsistence entrepreneurship. This paper considers one possible explanation: that the structure of existing microfinance contracts may discourage risky but high‐expected‐return investments. To explore this possibility, I develop a theory that unifies models of investment choice, informal risk‐sharing, and formal financial contracts. I then test the predictions of this theory using a series of experiments with clients of a large microfinance institution in India. The experiments confirm the theoretical predictions that joint liability creates two potential inefficiencies. First, borrowers free‐ride on their partners, making risky investments without compensating partners for this risk. Second, the addition of peer‐monitoring overcompensates, leading to sharp reductions in risk‐taking and profitability. Equity‐like financing, in which partners share both the benefits and risks of more profitable projects, overcomes both of these inefficiencies and merits further testing in the field.     

Metabolism and colonization. Modes of production and the physical exchange between societies and nature

Written by a sociologist and a biologist, this paper attempts an interdisciplinary approach to describing the basic exchange relations between human societies and their natural environments. One type of exchange relation is termed ‘metabolism’ and related to the biological metabolism member organisms of societies require. A historical overview (part 1) demonstrates this exchange relation in terms of mass throughput per inhabitant to have grown in the course of human cultural evolution—without necessarily increasing the quality of life of those concerned—to the twentyfold it now amounts to in industrial societies (as is demonstrated empirically for Austria in part 3). A strategy of ‘contraction of physical metabolism’ (reduction of physical growth irrespective of ‘economic’ growth) of industrial societies is proposed as a strategic means of survival and possible ways to this goal are discussed quantitatively. The other exchange relation termed ‘colonization’ refers to treatments of natural environments that purposively change some components to render better exploitability (for the purpose of social metabolism), while still relying upon their basic self‐regenerating qualities. It is sketched how colonization strategies developed historically, and it is demonstrated empirically that industrial societies now use about 50% of the available plant biomass (the energetic basis of all animal life) upon their territories for human purposes (part 4). Part 5 classifies different ‘paradigms’ for judging the ‘harmfulness’ of social interventions into the environment and outlines the logic of an information system that would enable society to generate an awareness of its own interventions into nature. On the whole the paper presents a theoretical as well as an empirical attempt to view societies as physical systems (among other physical systems on this planet) and confront sociology with the paradigmatic task to analyze the social regulation of these physical processes.     

International Migration and Gender in Latin America: A Comparative Analysis

We review census data to assess the standing of five Latin American nations on a gender continuum ranging from patriarchal to matrifocal. We show that Mexico and Costa Rica lie close to one another with a highly patriarchal system of gender relations whereas Nicaragua and the Dominican Republic are similar in having a matrifocal system. Puerto Rico occupies a middle position, blending characteristics of both systems. These differences yield different patterns of female relative to male migration. Female householders in the two patriarchal settings displayed low rates of out-migration compared with males, whereas in the two matrifocal countries the ratio of female to male migration was much higher, in some case exceeding their male counterparts. Multivariate analyses showed that in patriarchal societies, a formal or informal union with a male dramatically lowers the odds of female out-migration, whereas in matrifocal societies marriage and cohabitation have no real effect. The most important determinants of female migration from patriarchal settings are the migrant status of the husband or partner, having relatives in the United States, and the possession of legal documents. In matrifocal settings, however, female migration is less related to the possession of documents, partner's migrant status, or having relatives in the United States and more strongly related to the woman's own migratory experience. Whereas the process of cumulative causation appears to be driven largely by men in patriarchal societies, it is women who dominate the process in matrifocal settings.     

Sibling kinnections: a clinical visitation program

The growing literature on sibling relationships throughout their lifespans is of great importance to those working in the child welfare system, and in adoption services in particular. Sibling bonds are important to all of us, but they are particularly vital to children from disorganized or dysfunctional families. These relationships assume even greater importance when children from these families enter the care system. Supporting and sustaining these sibling bonds should be, and most often is, a priority throughout the child welfare system, with practice literature providing guidelines for arranging and sustaining sibling contact. However, children in the care system may also have dysfunctional sibling relationships as a result of their early experiences, and sibling visitation alone may not be enough to ensure a healthy, long-lasting relationship among siblings. Some form of sibling therapy, or 'clinically supervised visitation,' may be required to help children remove the barriers to form mutually satisfying relationships and to reinforce life-long relationships with each other.     

The History of College Health Nursing

Abstract

Almost from the beginning of formal college health programs in the second half of the 19th century, college health nurses were there to care for students in college and university settings. By the end of the 20th century, the role of college health nurses had evolved with the nursing field in general, but with enough unique features for the American Nurses’ Credentialing Center to recognize college health nursing as a professional subspecialty and administer the first College Health Nurse Certification examinations. In addition, new nurse practitioner programs provided practicing nurses with more independence, and their duties continued to expand beyond care of the sick to include health promotion, administrative, and teaching activities. As a result of these changes, college health nurses now play a larger role in the life of students and promoting a healthy campus community than ever before in the history of college health.     

The smallest user campaign to decrease energy consumption in two Mid-South neighborhoods: A field experiment

This report describes a partnership and campaign to build awareness and support for energy conservation in a Mid-South community. The partners included a state university, the local power company, and two neighborhoods in the local community. This partnership led to a field experiment that built community esprit along with increased knowledge of and attitudes toward energy conservation. It did not result in lower electricity and gas consumption. This attempt to influence citizen behavior featured extremely powerful pre-and post-test measures of unit electric and gas consumption.