Development of a Screening Approach to Interpret Human Biomonitoring Data on Volatile Organic Compounds: Reverse Dosimetry on Biomonitoring Data for Trichloroethylene

A screening approach is developed for volatile organic compounds (VOCs) to estimate exposures that correspond to levels measured in fluids and/or tissues in human biomonitoring studies. The approach makes use of a generic physiologically-based pharmacokinetic (PBPK) model coupled with exposure pattern characterization, Monte Carlo analysis, and quantitative structure property relationships (QSPRs). QSPRs are used for VOCs with minimal data to develop chemical-specific parameters needed for the PBPK model. The PBPK model is capable of simulating VOC kinetics following multiple routes of exposure, such as oral exposure via water ingestion and inhalation exposure during shower events. Using published human biomonitoring data of trichloroethylene (TCE), the generic model is evaluated to determine how well it estimates TCE concentrations in blood based on the known drinking water concentrations. In addition, Monte Carlo analysis is conducted to characterize the impact of the following factors: (1) uncertainties in the QSPR-estimated chemical-specific parameters; (2) variability in physiological parameters; and (3) variability in exposure patterns. The results indicate that uncertainty in chemical-specific parameters makes only a minor contribution to the overall variability and uncertainty in the predicted TCE concentrations in blood. The model is used in a reverse dosimetry approach to derive estimates of TCE concentrations in drinking water based on given measurements of TCE in blood, for comparison to the U.S. EPA's Maximum Contaminant Level in drinking water. This example demonstrates how a reverse dosimetry approach can be used to facilitate interpretation of human biomonitoring data in a health risk context by deriving external exposures that are consistent with a biomonitoring data set, thereby permitting comparison with health-based exposure guidelines.     

交通信息条件下道路和停车选择SUE模型及算法

考虑交通信息系统(advanced traveler information system,ATIS)对出行者道路和停车选择行为的影响,并将出行者分成两类:一类出行者使用ATIS,另一类不使用ATIS.在此基础上,构造了一个基于概率的随机用户均衡模型来描述ATIS条件下的道路和停车选择问题,并给出了相应的求解算法.最后,通过一个算例分析了模型及算法的使用效果.     

一类CRM模型的构建及其销售策略分析

从分析现有CRM(客户关系管理)系统的缺失入手,强调了销售以客户“人”为分析基点的重要性,在此基础上给出了一类销售过程的简化状态指标.应用该思路、指标、借助于Pfeifer和Carraway的思路、利用Markov链建立商家与客户关系模型,就有限次销售的一次交易、多次交易及无限次销售的情况分别给出相应分析结果.并考虑企业实际运作,进一步讨论了该模型下不同销售策略模型的响应.结果表明,减少成功率小的销售活动,企业期望获利会更大些.     

Gedanken zur Gestaltung einer professionellen Beratungsausbildung

Considerations on the design of a professional education of counselorsSome of the recently published articles about supervision-professionalizing are reflecting only sociological or psychological conceptions in order to describe and analyze professionality. In this article the authors discuss some of the mostly neglected points of view out of pedagogic and microsociologic professionalization-research (professional self, researching attitude). The existing requests of competence for supervisors are examined in order to test their teaching ability. Furthermore the content designs and didactic strategies for future counselor’s education are considered.     

Was ein Coach über Familienbetriebe wissen sollte Bücher über Familienunternehmen

This discourse presents three relevant books about family businesses. These books comprise the “minimum knowledge”, necessary for a coach who consults managers of family businesses. Different patterns of analysis of several disciplines, from the political economics up to the depth psychology, are referred to, and some family firms of different size and different age are described.     

Der Insolvenzprozess und die Eigenverwaltung in der Insolvenz auf Basis unterschiedlicher Theoriekonzepte

Zusammenfassung  Der Beitrag erkl?rt einerseits die Notwendigkeit eines durch Gesetz geregelten Verfahrens zur Insolvenzabwicklung mittels betriebswirtschaftlicher Grundlagentheorien. Andererseits werden dieselben Grundlagentheorien genutzt, um die unterschiedlichen sich ver?ndernden Machtstrukturen, die oft gegens?tzlichen Interessen von Stakeholdern, die Kosten des Insolvenzprozesses sowie deren Dynamik im Rahmen des vierphasigen Insolvenzprozesses (vor Insolvenzanmeldung, nach Antragstellung, nach Er?ffnung, nach Abschluss des Verfahrens) eines Not leidenden Unternehmens besser veranschaulichen zu k?nnen. Der besondere Schwerpunkt wird hierbei auf das Verfahren in Eigenverwaltung, das hei?t mit eigenem Management, gelegt.

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The bankruptcy process and the self-administration in the bankruptcy proceedings

Summary  This article explains on one hand the necessity of a legally fixed process for the bankruptcy proceedings with basic economic theories. On the other hand, the same theories are used to demonstrate the changing power structures, the often different interests of stakeholders, the costs of the bankruptcy proceedings as well as its dynamics during the four bankruptcy phases (before the filing, after the filing, after opening and after closing) of the bankruptcy process. The focus of this article lies hereby on bankruptcy proceedings in self-administration which means that the management stays on duty.

Dr. Martin K?rner ist promovierter Diplom- und Bankkaufmann und leitet die Abteilung Strategic Advisory bei einem führenden europ?ischen IT- und Telekommunikationsunternehmen. Seine Forschungsgebiete umfassen strategische Fragestellungen, Kapitalmarktthemen, das Outsorcing sowie das Krisen- und Insolvenzmanagement.     

Editorial

Ohne Zusammenfassung

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Editorial