Superstition effects versus cohort effects: is it bad luck to be born in the year of the fire horse in Japan?

The year of the fire horse (called “Hinoeuma” in Japanese) is one of the sixty Chinese zodiac symbols used to count years. According to superstition, fire horse women are said to have troubled marriages, to mistreat men, and to cause early deaths for their husbands and fathers. No such stigma applies to men born in these years. This paper attempts to investigate the impact of women’s birth in the most recent fire horse year (1966) on the outcome of their lives by using individual-level microdata. We find that there is no evidence of disadvantages to fire horse women in human capital investment, performance in the marriage market, or intra-household allocation of resources after marriage. We provide two plausible explanations for this lack of impact from the stigma: a cohort size effect and a dynamic transition in the share of arranged and love marriages. The latter affected parents’ decisions in 1966 as well as the performance of fire horse women in the marriage market and in intra-household resource allocation after marriage. This finding suggests the importance of careful attention to the dynamic effects of society and the economy that may occur before the emergence of a cohort size effect.     

Effect of design specifications in dose‐finding trials for combination therapies in oncology

Model‐based dose‐finding methods for a combination therapy involving two agents in phase I oncology trials typically include four design aspects namely, size of the patient cohort, three‐parameter dose‐toxicity model, choice of start‐up rule, and whether or not to include a restriction on dose‐level skipping. The effect of each design aspect on the operating characteristics of the dose‐finding method has not been adequately studied. However, some studies compared the performance of rival dose‐finding methods using design aspects outlined by the original studies. In this study, we featured the well‐known four design aspects and evaluated the impact of each independent effect on the operating characteristics of the dose‐finding method including these aspects. We performed simulation studies to examine the effect of these design aspects on the determination of the true maximum tolerated dose combinations as well as exposure to unacceptable toxic dose combinations. The results demonstrated that the selection rates of maximum tolerated dose combinations and UTDCs vary depending on the patient cohort size and restrictions on dose‐level skipping However, the three‐parameter dose‐toxicity models and start‐up rules did not affect these parameters. Copyright © 2016 John Wiley & Sons, Ltd.     

Sequential Estimation of Structural Models With a Fixed Point Constraint

This paper considers the estimation problem of structural models for which empirical restrictions are characterized by a fixed point constraint, such as structural dynamic discrete choice models or models of dynamic games. We analyze a local condition under which the nested pseudo likelihood (NPL) algorithm converges to a consistent estimator, and derive its convergence rate. We find that the NPL algorithm may not necessarily converge to a consistent estimator when the fixed point mapping does not have a local contraction property. To address the issue of divergence, we propose alternative sequential estimation procedures that can converge to a consistent estimator even when the NPL algorithm does not.     

Nonparametric Identification of Finite Mixture Models of Dynamic Discrete Choices

In dynamic discrete choice analysis, controlling for unobserved heterogeneity is an important issue, and finite mixture models provide flexible ways to account for it. This paper studies nonparametric identifiability of type probabilities and type‐specific component distributions in finite mixture models of dynamic discrete choices. We derive sufficient conditions for nonparametric identification for various finite mixture models of dynamic discrete choices used in applied work under different assumptions on the Markov property, stationarity, and type‐invariance in the transition process. Three elements emerge as the important determinants of identification: the time‐dimension of panel data, the number of values the covariates can take, and the heterogeneity of the response of different types to changes in the covariates. For example, in a simple case where the transition function is type‐invariant, a time‐dimension of T = 3 is sufficient for identification, provided that the number of values the covariates can take is no smaller than the number of types and that the changes in the covariates induce sufficiently heterogeneous variations in the choice probabilities across types. Identification is achieved even when state dependence is present if a model is stationary first‐order Markovian and the panel has a moderate time‐dimension (T 6).     

Quantitative analyses of misclassification rates in the hazard classification of environmental chemicals: Evaluation of procedures for deriving predicted no-effect concentrations in the Chemical Substance Control Law in Japan

The quality of chemical management depends more or less on practical procedures used to assess chemicals. This study quantitatively assessed the efficacy of a derivation procedure for calculating no-effect concentrations for screening assessment of environmental hazards under the Chemical Substance Control Law in Japan. We first evaluated the derivation procedure by applying a series of test ecotoxicity datasets to the procedure and calculating the resulting misclassification rates of the hazardous class of chemicals. In this study, a chemical was deemed to have been misclassified if its classification differed from its classification based on the full dataset (chronic toxicity data for three trophic levels), which was defined as the correct assignment. We also calculated the effects of additional uncertainty factors to decrease the variance (i.e., to improve the consistency) of the misclassification rates among cases with different data availability in the derivation procedure. The results showed that the derivation procedure resulted in very high rates of misclassification when only particular sets of ecotoxicity data were available (e.g., only chronic toxicity data of algae were available). Our analyses also showed that the use of additional uncertainty factors improved the consistency of the misclassification rates within the derivation procedure. Our study presents a broadly applicable calculation framework for quantifying error rates in assessment procedures and serves as a case study for future development and reforms of chemical assessment processes and policies, while additional analyses using more extensive ecotoxicity data with various modes of actions are needed in the future.