A survey on nonadaptive group testing algorithms through the angle of decoding

Group testing, sometimes called pooling design, has been applied to a variety of problems such as blood testing, multiple access communication, coding theory, among others. Recently, screening experiments in molecular biology has become the most important application. In this paper, we review several models in this application by focusing on decoding, namely, giving a comparative study of how the problem is solved in each of these models.     

A reactive tabu search algorithm for the vehicle routing problem with simultaneous pickups and deliveries

The vehicle routing problem with pickups and deliveries (VRPPD) extends the vehicle routing problem (VRP) by allowing customers to both send and receive goods. The main difficulty of the problem is that the load of vehicles is fluctuating rather than decreasing as in the VRP. We design a reactive tabu search metaheuristic that can check feasibility of proposed moves quickly and reacts to repetitions to guide the search. Several new best solutions are found for benchmark problems.     

Present bias and health

This study uses a dynamic discrete choice model to examine the degree of present bias and naivete about present bias in individuals’ health care decisions. Clinical guidelines exist for several common chronic diseases. Although the empirical evidence for some guidelines is strong, many individuals with these diseases do not follow the guidelines. Using persons with diabetes as a case study, we find evidence of substantial present bias and naivete. Counterfactual simulations indicate the importance of present bias and naivete in explaining low adherence rates to health care guidelines.     

Bimodality based on the generalized skew-normal distribution

This paper focuses on the development of a new extension of the generalized skew-normal distribution introduced in Gómez et al. [Generalized skew-normal models: properties and inference. Statistics. 2006;40(6):495–505]. To produce the generalization a new parameter is introduced, the signal of which has the flexibility of yielding unimodal as well as bimodal distributions. We study its properties, derive a stochastic representation and state some expressions that facilitate moments derivation. Maximum likelihood is implemented via the EM algorithm which is based on the stochastic representation derived. We show that the Fisher information matrix is singular and discuss ways of getting round this problem. An illustration using real data reveals that the model can capture well special data features such as bimodality and asymmetry.     

On the mixtures of Weibull and Pareto (IV) distribution: An alternative to Pareto distribution

Finite mixture models have provided a reasonable tool to model various types of observed phenomena, specially those which are random in nature. In this article, a finite mixture of Weibull and Pareto (IV) distribution is considered and studied. Some structural properties of the resulting model are discussed including estimation of the model parameters via expectation maximization (EM) algorithm. A real-life data application exhibits the fact that in certain situations, this mixture model might be a better alternative than the rival popular models.     

Computer experiment designs for accurate prediction

Computer experiments using deterministic simulators are sometimes used to replace or supplement physical system experiments. This paper compares designs for an initial computer simulator experiment based on empirical prediction accuracy; it recommends designs for producing accurate predictions. The basis for the majority of the designs compared is the integrated mean squared prediction error (IMSPE) that is computed assuming a Gaussian process model with a Gaussian correlation function. Designs that minimize the IMSPE with respect to a fixed set of correlation parameters as well as designs that minimize a weighted IMSPE over the correlation parameters are studied. These IMSPE-based designs are compared with three widely-used space-filling designs. The designs are used to predict test surfaces representing a range of stationary and non-stationary functions. For the test conditions examined in this paper, the designs constructed under IMSPE-based criteria are shown to outperform space-filling Latin hypercube designs and maximum projection designs when predicting smooth functions of stationary appearance, while space-filling and maximum projection designs are superior for test functions that exhibit strong non-stationarity.     

Fast computation of spatially adaptive kernel estimates

Kernel smoothing of spatial point data can often be improved using an adaptive, spatially varying bandwidth instead of a fixed bandwidth. However, computation with a varying bandwidth is much more demanding, especially when edge correction and bandwidth selection are involved. This paper proposes several new computational methods for adaptive kernel estimation from spatial point pattern data. A key idea is that a variable-bandwidth kernel estimator for d-dimensional spatial data can be represented as a slice of a fixed-bandwidth kernel estimator in \((d+1)\)-dimensional scale space, enabling fast computation using Fourier transforms. Edge correction factors have a similar representation. Different values of global bandwidth correspond to different slices of the scale space, so that bandwidth selection is greatly accelerated. Potential applications include estimation of multivariate probability density and spatial or spatiotemporal point process intensity, relative risk, and regression functions. The new methods perform well in simulations and in two real applications concerning the spatial epidemiology of primary biliary cirrhosis and the alarm calls of capuchin monkeys.     

Nonparametric estimation of the multivariate survivor function: the multivariate Kaplan–Meier estimator

The Dabrowska (Ann Stat 16:1475–1489, 1988) product integral representation of the multivariate survivor function is extended, leading to a nonparametric survivor function estimator for an arbitrary number of failure time variates that has a simple recursive formula for its calculation. Empirical process methods are used to sketch proofs for this estimator’s strong consistency and weak convergence properties. Summary measures of pairwise and higher-order dependencies are also defined and nonparametrically estimated. Simulation evaluation is given for the special case of three failure time variates.     

Two-phase outcome-dependent studies for failure times and testing for effects of expensive covariates

Two- or multi-phase study designs are often used in settings involving failure times. In most studies, whether or not certain covariates are measured on an individual depends on their failure time and status. For example, when failures are rare, case–cohort or case–control designs are used to increase the number of failures relative to a random sample of the same size. Another scenario is where certain covariates are expensive to measure, so they are obtained only for selected individuals in a cohort. This paper considers such situations and focuses on cases where we wish to test hypotheses of no association between failure time and expensive covariates. Efficient score tests based on maximum likelihood are developed and shown to have a simple form for a wide class of models and sampling designs. Some numerical comparisons of study designs are presented.