Stochasticity in Physiologically Based Kinetics Models: Implications for Cancer Risk Assessment

In case of low-dose exposure to a substance, its concentration in cells is likely to be stochastic. Assessing the consequences of this stochasticity in toxicological risk assessment requires the coupling of macroscopic dynamics models describing whole-body kinetics with microscopic tools designed to simulate stochasticity. In this article, we propose an approach to approximate stochastic cell concentration of butadiene in the cells of diverse organs. We adapted the dynamics equations of a physiologically based pharmacokinetic (PBPK) model and used a stochastic simulator for the system of equations that we derived. We then coupled kinetics simulations with a deterministic hockey stick model of carcinogenicity. Stochasticity induced substantial modifications relative to dose-response curve, compared with the deterministic situation. In particular, there was nonlinearity in the response and the stochastic apparent threshold was lower than the deterministic one. The approach that we developed could easily be extended to other biological studies to assess the influence of stochasticity at macroscopic scale for compound dynamics at the cell level.     

Do Infants Show Distinct Negative Facial Expressions for Fear and Anger? Emotional Expression in 11‐Month‐Old European American,Chinese, and Japanese Infants

Do infants show distinct negative facial expressions for different negative emotions? To address this question, European American, Chinese, and Japanese 11‐month‐olds were videotaped during procedures designed to elicit mild anger or frustration and fear. Facial behavior was coded using Baby FACS, an anatomically based scoring system. Infants' nonfacial behavior differed across procedures, suggesting that the target emotions were successfully elicited. However evidence for distinct emotion‐specific facial configurations corresponding to fear versus anger was not obtained. Although facial responses were largely similar across cultures, some differences also were observed. Results are discussed in terms of functionalist and dynamical systems approaches to emotion and emotional expression.     

Working around the Barriers to Creating and Sharing Knowledge in Capital Goods Projects: the Client's Perspective*

The article considers knowledge management issues from the client's perspective. In the example presented, a sludge treatment centre procured by Northumbrian Water Ltd (NWL), the task faced by the client was to manage knowledge in a context where the core technology being procured was new and resulted in the need for new knowledge to be created and shared both pre‐ and post‐delivery. In exploring these issues, the article reveals the problems of (and some solutions to) managing knowledge across the project life‐cycle and between different groups, where the motivation for generating and sharing knowledge was not the same for all participants.     

“Scissors,Please”: The Practical Accomplishment of Surgical Work in the Operating Theater

The focus of this article is on professional activity in the operating theater. We explore how surgeons and nurses organize their activities, how social interaction is used to help structure and define situations, and how differentials in knowledge are constructed and oriented to. We utilize some ideas and concepts from symbolic interactionism, ethnomethodology, and conversation analysis to analyze small clips of audio‐ and video‐recorded interaction. Focusing on how surgeons and nurses request, provide, and apply surgical instruments, the analysis shows how surgical work is accomplished through talk and bodily conduct. We conclude that, examined in detail, the social interaction between surgeons and nurses is analytically inseparable from the “technical” demands of their work.     

Economic Resourcefulness: Definition and Modeling

Social Indicators Research - The amount of income earned, wealth and position in the labor market are determined by many factors. Numerous analyses indicate that these characteristics depend on,...     

Self-monitoring and 360-degree ratings

We examined the relationship between self-monitoring (SM) and supervisor, assessor, peer, and subordinate ratings for 191 managers who participated in a developmental assessment center. We collected self-ratings from the managers concerning their ability and motivation to engage in self-monitoring. SM ability was positively related to supervisor and assessor ratings of interpersonal effectiveness (e.g., empowerment, managing teams, influencing others) but was unrelated to supervisor and assessor ratings of business competence (e.g., planning, decision making, strategic thinking, business knowledge). In contrast, SM motivation was negatively related to peer ratings of business competence. Still, SM explained relatively little variance in 360-degree ratings. 360-degree ratings do not appear to be contaminated by the target manager's SM; the small but significant relationship between SM ability and ratings appears to be job-related (and therefore desirable).