A critique of arguments supporting disability avoidance

Many prominent bioethicists argue that positive consequences follow from avoiding disability in offspring by preconceptual, preimplantation or prenatal means. This paper critiques two variants of these positions: ‘Open future’ arguments that avoiding disability is in the interest of the persons who will be affected by it if born and ‘non‐person‐affecting’ claims that failures to avoid disability in offspring are wrong for reasons independent of their effect on affected offspring. Difficulties with both person‐affecting and non‐person‐affecting accounts are discussed in support of the charge that these arguments do not show that positive consequences follow from disability avoidance.     

Familism Values,Perspective Taking,and Prosocial Moral Reasoning: Predicting Prosocial Tendencies Among Mexican American Adolescents

Mexican American youth often engage in relatively high levels of prosocial behaviors. We theorize that this may be due to a cultural value system that encourages familism values, which, in turn, may foster the development of sociocognitive processes that promote prosocial behaviors. Two hundred and five Mexican American early adolescent youth (M_age = 10.9 years, SD = 0.84; 51% girls) reported their familism values, perspective taking, prosocial moral reasoning, and six types of prosocial behaviors. The results indicated that perspective taking partially mediated the relation between familism values and the specific prosocial tendencies theoretically linked to the Mexican American culture. The study demonstrated the utility of integrating cultural and traditional developmental mechanisms in attempting to explain prosocial behaviors.     

Metropolitan influences on migration into poor and nonpoor neighborhoods

Data from the Panel Study of Income Dynamics and three decennial US censuses are used to examine the influence of metropolitan-area characteristics on black and white households’ propensity to move into poor versus nonpoor neighborhoods. We find that a nontrivial portion of the variance in the odds of moving to a poor rather to a nonpoor neighborhood exists between metropolitan areas. Net of established individual-level predictors of inter-neighborhood migration, black and white households are more likely to move to a poor or extremely poor tract rather than to a nonpoor tract in metropolitan areas containing many poor neighborhoods and a paucity of recently-built housing in nonpoor areas. Blacks are especially likely to move to a poor tract in metropolitan areas characterized by high levels of racial residential segregation and in which poor tracts have a sizeable concentration of blacks. White households are more likely to move to a poor than to a nonpoor tract in metropolitan areas that have comparatively few African Americans.     

Affirmative Reaction: The Influence of Type of Justification on Nonbeneficiary Attitudes Toward Affirmative Action Plans in Higher Education

It is popularly believed that justifying an affirmative action plan (AAP) through emphasizing the advantages that diverse students can bring to a college campus will increase nonbeneficiary support for the program. However, there has been little empirical support for this proposition, perhaps because previous research has not directly articulated to participants the value of a diverse student body. As such, the current study sought to determine how the explicit framing of an AAP influences subsequent reactions. Both quantitative and qualitative data from 216 White undergraduate participants revealed that the utilitarianism justification that highlighted the benefits of the AAP to both minority and majority students, was the most effective means of increasing support for the plan.     

Advocacy for disabled children and young people: benefits and dilemmas

Recent policy has emphasized the need for advocacy services for children and young people, developments that have gone hand‐in‐hand with greater levels of participation of young people in decision‐making. Advocacy for disabled young people is especially important, as they are a particular vulnerable group and have, traditionally, been even more excluded from decisions about matters affecting their lives. This paper reports the findings, as they relate to disabled young people, from a study that investigated the role of advocacy for looked‐after children and children in need. The paper highlights some of the benefits of advocacy for disabled children, the dilemmas facing advocates between advocating and acting in someone's ‘best interests’, identifying the client and the boundaries between advocacy and social work. It argues that time given to establish a close relationship with a disabled child or young person is crucial if advocacy is to be effective and participation in decisions affecting their lives a reality.     

Using In Vitro High‐Throughput Screening Data for Predicting Benzo[k]Fluoranthene Human Health Hazards

Today there are more than 80,000 chemicals in commerce and the environment. The potential human health risks are unknown for the vast majority of these chemicals as they lack human health risk assessments, toxicity reference values, and risk screening values. We aim to use computational toxicology and quantitative high‐throughput screening (qHTS) technologies to fill these data gaps, and begin to prioritize these chemicals for additional assessment. In this pilot, we demonstrate how we were able to identify that benzo[k]fluoranthene may induce DNA damage and steatosis using qHTS data and two separate adverse outcome pathways (AOPs). We also demonstrate how bootstrap natural spline‐based meta‐regression can be used to integrate data across multiple assay replicates to generate a concentration–response curve. We used this analysis to calculate an in vitro point of departure of 0.751 μM and risk‐specific in vitro concentrations of 0.29 μM and 0.28 μM for 1:1,000 and 1:10,000 risk, respectively, for DNA damage. Based on the available evidence, and considering that only a single HSD17B4 assay is available, we have low overall confidence in the steatosis hazard identification. This case study suggests that coupling qHTS assays with AOPs and ontologies will facilitate hazard identification. Combining this with quantitative evidence integration methods, such as bootstrap meta‐regression, may allow risk assessors to identify points of departure and risk‐specific internal/in vitro concentrations. These results are sufficient to prioritize the chemicals; however, in the longer term we will need to estimate external doses for risk screening purposes, such as through margin of exposure methods.     

Ambulance allocation for maximal survival with heterogeneous outcome measures

This paper proposes new models for locating emergency medical services (EMS) by incorporating survival functions for capturing multiple-classes of heterogeneous patients. The Maximal Expected Survival Location Model for Heterogeneous Patients (MESLMHP) aims to maximize the overall expected survival probability of multiple-classes of patients, whereby different classes could be defined according to agreed patient categories based on response time targets, or by capturing differing medical conditions each with a corresponding survival function. Furthermore, we propose and demonstrate an approximation approach to solving the extended stochastic version of MESLMHP, which utilizes queuing theory to permit the modeling of congestion and utilization at each ambulance station, and does not require assumptions to be made on the utilization of ambulances. Both models are demonstrated using data from the ambulance service in Wales. We show that our multiple outcome measures and survival-maximizing approach, rather than one based on average response time targets alone or a single patient class provides more effective EMS ambulance allocations.     

The Association of Survey Setting and Mode with Self-Reported Health Risk Behaviors among High School Students

This study examined whether the prevalence of self-reportedhealth risk behaviors among high school students varied by surveysetting (school versus home) and mode of administration (paperand pencil versus computer). Students in grades 9 and 11 wereassigned randomly to one of four conditions—school paper-and-pencilinstrument (PAPI), school computer-assisted self-interview (CASI),home PAPI, and home CASI. During the spring of 2004, 4,506 studentscompleted identically worded questionnaires based on the YouthRisk Behavior Survey questionnaire. Logistic regression analysescontrolling for sex, grade, and race/ethnicity revealed thatsetting was associated significantly with the reporting of 30of the 55 risk behaviors examined, and mode was associated significantlywith the reporting of 7 of the 55 behaviors. For all behaviorswith a significant setting main effect, the odds of reportingthe behavior were greater among students who completed questionnairesat school than among students who completed questionnaires athome. For all behaviors with a significant mode main effect,PAPI mode students had lower odds of reporting the behaviorthan CASI mode students. Because social measurement researchassumes that higher prevalence estimates are more valid thanlower estimates, methodological factors shown to increase estimates,such as setting and mode, should be considered when planningsurveys.     

Positioning terrorism in management and marketing: Research propositions

Terrorism poses both direct and indirect threats to the operations of the firm. It represents a market imperfection that increases transaction costs and creates barriers to the free flow of goods, affecting potential gains that would occur in the presence of unhindered exchange. Terrorism reflects the risk or actual encounter of violent acts, whose goal is to engender fear, coercion, or intimidation. We investigate terrorism and its association with marketing strategy and operations. Key concepts on terrorism are reviewed and a collection of propositions is offered. We highlight the pivotal roles of sourcing, production, distribution, pricing, communications, and general business strategy as functions influenced by, or capable of influencing, terrorism. Lastly, we offer managerial implications, as well as directions and guidelines for future research.