Estimation of gene/haplotype frequencies in genetic marker systems based on phenotype data

Two equivalent methods (gene counting and maximum likelihood) for estimating gene frequencies in a general genetic marker system based on observed phenotype data are derived. Under the maximum likelihood approach, an expression is given for the estimated covariance matrix from which estimated standard errors of the estimators can be found. In addition, consideration is given to the problem of estimating gene frequencies when there are available several independent population data sets.     

Estimating the discovery rate in a continuous time recapture model

We consider a family of marked Poisson process models for the discovery of distinct errors in a computer program and also for sampling, in continu-ous time, a population containing an unknown number of distinct biological species. Captures (selections or discoveries) are assumed to occur at a con-stant rate, each event consisting of the discovery of a distinct process (error or species) or the recurrence of a previously discovered process. Using a generalization of Nayak’s (1988) model we derive confidence limits for the discovery rate. The limits are based on the asymptotic distribution of a scaled logarithmic function of the maximum likelihood estimator.     

Social movement schools: sites for consciousness transformation,training, and prefigurative social development

ABSTRACT

We develop the concept of “social movement school’ (SMS), showing how these organizational spaces are deliberately designed for purposes of educating, mentoring, training, and coordinating individuals as effective, committed movement agents. SMSs can also be important sites of prefigurative design and practice for future societal development consistent with movement goals. We motivate the theoretical significance of SMSs based on five perspectives in social movement scholarship: (1) resource mobilization; (2) cultural approaches to repertoires of contention; (3) cognitive perspective; (4) micro-mobilization; and (5) biographical consequences of participation. We then offer a typology to capture primary purposes, and spatial reach within the broad field of SMSs. Within-movement variation is illustrated by focusing on a variety of SMSs in the U.S. civil rights movement; and the cross-movement breadth of the concept is illustrated by highlighting contemporary SMS forms drawn from three very different movements–labor, radical feminism, and mindfulness meditation movements. In the interest of launching a research agenda on SMSs, we end with several key questions that could serve to guide future research. Important theoretical, empirical, and practical considerations suggest that SMSs deserve the attention of scholars and activists alike.     

Subjective Probabilities on Subjectively Unambiguous Events

This paper suggests a behavioral definition of (subjective) ambiguity in an abstract setting where objects of choice are Savage‐style acts. Then axioms are described that deliver probabilistic sophistication of preference on the set of unambiguous acts. In particular, both the domain and the values of the decision‐maker's probability measure are derived from preference. It is argued that the noted result also provides a decision‐theoretic foundation for the Knightian distinction between risk and ambiguity.     

Ambiguity,Risk, and Asset Returns in Continuous Time

Models of utility in stochastic continuous–time settings typically assume that beliefs are represented by a probability measure, hence ruling out a priori any concern with ambiguity. This paper formulates a continuous–time intertemporal version of multiple–priors utility, where aversion to ambiguity is admissible. In a representative agent asset market setting, the model delivers restrictions on excess returns that admit interpretations reflecting a premium for risk and a separate premium for ambiguity.     

Organizational Learning in Global Purchasing: A Model and Test of Internal Users and Corporate Buyers*

This research examines a model centered on organizational learning in purchasing. Two different studies are conducted to test the hypotheses among purchasing users (Study 1) and buyers (Study 2). The user sample consists of users representing 355 strategic business units of a Fortune 500 multinational corporation. The buyer sample consists of corporate buyers of 200 multinational corporations drawn from the membership directory of the National Association of Purchasing Management (NAPM). In each study, the focus is on the learning relationships between corporate buyers and internal users in the purchasing organization. Based on the two studies, the results suggest that organizational learning in the purchasing process is influenced by the organizational culture factors of localness, transformational leadership, and openness. Organizational learning has a positive effect on information processing in the purchasing system, which, in turn, has a positive influence on the cycle time of the purchasing process.     

LINKING PROCESS CHOICE WITH PLANT-LEVEL DECISIONS ABOUT CAPITAL AND HUMAN RESOURCES

We examine how process choice links with design decisions about capital and human resources. Our analysis confirms empirically most expected differences between process- and product-focused plants for these decisions. What is unexpected is how top-performing plants resemble other plants within the same process choice category in most respects, while distinguishing themselves on a few selected process attributes. For example, better performing process-focused plants not only achieve higher machine flexibility levels and lower overhead costs as expected, but also have more intensive preventive maintenance programs. Similarly, product-focused plants that achieve certain hallmarks of process-focused plants also enjoy superior performance.