Postnatal Effects of Prenatal Insult

Exogenous agents may perturb development during the embryonic period and adversely affect the formation of organs. However, adverse effects on development are not limited to the embryonic period nor are the manifestations restricted solely to outright gross structural malformation, but may instead be expressed as a decrement or abberration of postnatal function. Susceptibility to altered development may extend well into the postnatal period. Studies of functional parameters in several organ systems have demonstrated the broad-based susceptibility, subtlety of expression and potential of long-lasting effects of altered development assessed by physiologic assays. Adverse effects on functional development, whether in the CNS, reproductive, gastrointestinal, genitourinary, respiratory, or immune systems, etc., merit continuing investigation. From the viewpoint of risk estimation and hazard detection, evaluations of postnatal functional parameters may be relevant for several reasons. First, such parameters may serve as low-dose triggers. Second, they may be useful as a focal point for epidemiological studies. Finally, a more thorough understanding of the degree and magnitude of such postnatal functional deficits is needed since an adverse maternal effect may be transient, considered acceptable, or unperceived, but the effect on the conceptus may be permanent and severe. The immune and respiratory systems are discussed as two examples of how subtle and protean adverse effects on functional development may be.     

Delta Method,Moment Convergence,and Inference

Statistics, as functions of the observations, are usually given by well-behaved functions. This fact is used to obtain limit distributions for statistics whose components are given by asymptotically linear functions. These results are then extended to the moments of distributions, covariance matrices and confidence regions for parameters of interest. These regions may be used to test, through duality, hypothesis on these parameters. A theoretical application is presented.     

What Narrows the Stepgap? Closeness Between Parents and Adult (Step)Children in Germany

Using data from the German Family Panel (pairfam) based on 11,746 intergenerational family relationships, the present study examined differences in parental closeness across relations with multiple, coresidential, and non‐coresidential adolescent and adult children. Replicating previous research in a multilevel analysis across families, the authors found a strong positive effect of biological descent on closeness in comparison to adoptive and steprelations; this parental favoritism toward biological offspring was partly explained by selection via parental resources and attitudes. Supplemental within‐parent fixed effect analyses suggested that the relative disadvantage of stepchildren was offset by longer duration of the stepparent–stepchild relationship, lower household income, fewer children in the household, and high parental affirmation of familism.     

Variations in Natural Fertility: The Effect of Lactation and Other Determinants

The analysis focuses on average waiting times to a fertile conception, as derived from non-contraceptive exposure in second and higher-order birth intervals. Life-table estimates are derived from exposure in the two-year periods preceding the survey, for 20 surveys in Africa, Asia and Latin America undertaken as part of the WFS programme. Differences in the waiting time to conception are examined as a function of the duration of lactation and post partum abstinence. In addition, the extent to which variations in waiting times are produced by country and regional effects, and effects due to age, duration of marriage and parity are examined. The analysis points out the dangers of deriving estimates of natural fertility from the sub-group of women who never breastfed.     

The emergence of thanatology and current practice in death education

Thanatology is a recent field that contemplates death studies and employs an interdisciplinary approach to practice. This science emerged in a historical context marked by intense social, economic, and political changes that contributed to the concept of death being excluded from social life. This literature review aims to outline the history and evolution ofthanatology in Western society, delineating the contextual circumstances that led to its origin and drawing special attention to current works on death education. In our post-modern society, the call for studies in the field of thanatology appears to be increasing. However, although there have been significant contributions and promising research is underway, there are still many questions to be answered.     

Tools for screening for interpersonal violence: state of the science

In recent decades, the prevalence of abuse against women, older persons, and persons with disabilities has become a major public health problem. Health professionals, urged by their professional associations to universally screen these groups, have employed various tools in an effort to identify individuals in need of help. Yet many of the tools used widely in clinical settings have limitations in terms of empirical soundness. This article presents tools used to screen women, older persons, and persons with disabilities as well as data on the reliability and validity of these instruments. These properties and the resources needed to reduce harm are important factors to consider before implementing screening. The article concludes with a summary of the risk-benefit issues related to the use of these tools and universal screening in general.