Quantifying Potential Health Impacts of Cadmium in Cigarettes on Smoker Risk of Lung Cancer: A Portfolio-of-Mechanisms Approach

This article introduces an approach to estimating the uncertain potential effects on lung cancer risk of removing a particular constituent, cadmium (Cd), from cigarette smoke, given the useful but incomplete scientific information available about its modes of action. The approach considers normal cell proliferation; DNA repair inhibition in normal cells affected by initiating events; proliferation, promotion, and progression of initiated cells; and death or sparing of initiated and malignant cells as they are further transformed to become fully tumorigenic. Rather than estimating unmeasured model parameters by curve fitting to epidemiological or animal experimental tumor data, we attempt rough estimates of parameters based on their biological interpretations and comparison to corresponding genetic polymorphism data. The resulting parameter estimates are admittedly uncertain and approximate, but they suggest a portfolio approach to estimating impacts of removing Cd that gives usefully robust conclusions. This approach views Cd as creating a portfolio of uncertain health impacts that can be expressed as biologically independent relative risk factors having clear mechanistic interpretations. Because Cd can act through many distinct biological mechanisms, it appears likely (subjective probability greater than 40%) that removing Cd from cigarette smoke would reduce smoker risks of lung cancer by at least 10%, although it is possible (consistent with what is known) that the true effect could be much larger or smaller. Conservative estimates and assumptions made in this calculation suggest that the true impact could be greater for some smokers. This conclusion appears to be robust to many scientific uncertainties about Cd and smoking effects.     

Runaway Reactions, Their Courses, and the Methods to Establish Safe Process Conditions

The purpose of this paper is to describe the various process deviations which can cause a runaway reaction to occur, and to discuss the experimental information necessary for risk assessment, the choice of a safe process, and the mitigation of the consequences of the runaway reaction. Ten typical hazardous process situations have been identified, considering various modes of initiation, homogeneous and heterogeneous, Arrhenius, and autocatalytic reactions. Each possible hazardous process deviation is illustrated by examples from the process industry and/or relevant experimental information obtained from laboratory experiments.     

The influence of rural-urban migration on migrants' fertility in Korea,Mexico and Cameroon

The paper presents a comparative analysis of the relationship between rural-urban migration and fertility in Korea, Mexico, and Cameroon. Using an autoregressive model, the results show a significant rural-urban migration adaptation effect in Korea and Mexico, a reduction of 2.57 and 1.45 children during the entire childbearing period, respectively, when compared to a rural stayer, even after the effect of selection has been controlled. Rural-urban migration has a very small impact on fertility in Cameroon. The unexpected result for Cameroon is due to the fact that the fertility-increasing effect of urban residency on the improved supply conditions of births, such as reduced infertility, offsets the fertility-depressing effect of urban residency on the demand for births. As a result of the adaptation to urban fertility norms, the number of country-wide births was reduced significantly in Mexico and Korea over the time periods studied.     

Moderniser la confiance L'assurance-qualité comme décontextualisation de la sous-traitance industrielle*

Quality assurance is an institution typical of the global economy in the context of advanced modernity. It decontextualizes economic behaviour in time and space (Luhmann, Giddens). An empirical study of the relations between Alcan Canada Ltd. and five subcontracting firms operating in the Saguenay—Lac-Saint-Jean area of Quebec shows that the abstract and extralocal standards of quality assurance transform the subcontractors social processes of selection and performance evaluation. The participation of quality assurance experts in the inter-firm relationships lessens the reliance on traditional relationships of trust, in favour of a new trust in abstract systems and expertise. L'assurance-qualité est une institution typique de la globalisation de l'économie dans le contexte de la modernité avancée. Elle décontex-tualise les comportements économiques dans le temps et dans l'espace (Luhmann, Giddens). Une étude empirique des relations d'Alcan Canada limitée avec cinq entreprises de la région du Saguenay-Lac-Saint-Jean (Québec) montre que les standards abstraits et extralocaux de l'assurance-qualité changent le processus social de sélection et d'évaluation du rendement des sous-traitants. L'intervention des experts de l'assurance-qualité dans les relations interfirmes diminue l'importance des rapports de confiance traditionnels au profit d'une nouvelle confiance-systeme.     

The Political Sociology of Counter-Revolution: The Case of Brazil

Books reviewed in this articles:
Politics in Brazil 1930–1964: An Experiment in Democracy. By T homas E. S kidmore .
Brazilian Planning: Development Politics and Administration. By R obert T. D aland .
Le Brésil. Special issue of Les Temps Modernes.     

What sex abusers say about their treatment: results from a qualitative study on pedophiles in treatment at a Canadian penitentiary clinic

This exploratory study used qualitative methodology to examine what pedophiles think about treatment, as well as their daily experience of a treatment program. To this end, twenty-three offenders receiving treatment from the La Macaza federal penitentiary clinic were interviewed using non-directive semi-structured interviews. Comparative analysis was used to analyze the resulting material. The following themes are discussed based on the results of this analysis: (a) the participants' past experience of therapy; (b) motivations for choosing the La Macaza clinic for treatment; (c) the structure of the program; (d) the group dynamics; (e) the therapists; and (f) the hardships and difficulties of treatment. Results suggest that the therapists and the program may have a function of containment or holding. Although part of the therapeutic process involves a focus on identifying and reducing cognitive distortions, results also warn therapists against misusing this concept by applying it to legitimately different opinions. Findings are discussed in terms of possible program improvements. The authors conclude that greater attention must be given to process research.     

原子簇的合成方法、性质表征与结构

利用给电子有机和无机配位体的交换反应和金属卤化物与羰基金属阴离子的复分解反应,合成异核原子簇具有反应条件温和易于控制,收率较高的特点。本文描述Fe_3(CO)_9(C_2H_2)_3等11个原子簇的合成方法,配位状态与簇核的结构。