Optimal adaptive sequential designs for crossover bioequivalence studies

In prior works, this group demonstrated the feasibility of valid adaptive sequential designs for crossover bioequivalence studies. In this paper, we extend the prior work to optimize adaptive sequential designs over a range of geometric mean test/reference ratios (GMRs) of 70–143% within each of two ranges of intra‐subject coefficient of variation (10–30% and 30–55%). These designs also introduce a futility decision for stopping the study after the first stage if there is sufficiently low likelihood of meeting bioequivalence criteria if the second stage were completed, as well as an upper limit on total study size. The optimized designs exhibited substantially improved performance characteristics over our previous adaptive sequential designs. Even though the optimized designs avoided undue inflation of type I error and maintained power at 80%, their average sample sizes were similar to or less than those of conventional single stage designs. Copyright © 2015 John Wiley & Sons, Ltd.     

Mobilities and Knowledge Transfer: Understanding the Contribution of Volunteer Stays to North–South Healthcare Partnerships

In this paper, I review recent literature on the relationship between human mobility and knowledge transfer processes, and apply some of the more theoretical ideas to an evaluation of the kinds of mobility in which UK participants engage in the context of North–South healthcare partnerships (HCPs). Much of the contemporary research on highly skilled mobility highlights the role that short stays and circular mobility play in knowledge transfer processes. I consider the value of short stays in the travel–mobility–migration continuum and the contribution they make to the transfer, translation and effectiveness of knowledge. Healthcare partnerships are best conceptualized as knowledge networks, with various forms of mobility (both physical and virtual) playing a critical role in network‐generation, evolution and impact. I outline the findings of two studies. The first is an evaluation of HCPs (Ackers and Porter, 2011) and the second an in‐depth ongoing evaluation of one HCP known as the Liverpool–Mulago Partnership or LMP¹ (Porter et al., 2011). The results raise questions about the relationship between the different types of mobility that participants in HCPs (predominantly professional volunteers) engage in, particularly the duration and repeated quality of stays, and knowledge transfer processes. Williams argues that “there are still major gaps in our understanding of the specific contribution of international migration to knowledge transfer, of the processes involved, and of the conditions that facilitate this” (2006 588). In this paper, I begin to close some of these gaps and advance our understanding of the relationship between different forms of mobility and knowledge transfer processes, in the hopes that this will build the evidence base supporting the contribution of North–South HCPs to the achievement of the Millennium Development Goals ² .     

‘Don't Make Us Talk!’: Listening to and Learning from Children and Young People Living with Parental Alcohol Problems

Given the common issues of secrecy, shame and stigma, we know very little about the lives of children affected by parental alcohol problems from their own perspectives. Thirty children and young people (aged between 9 and 20) chose to communicate about this sensitive issue as part of a Scottish qualitative study. This study reveals how children and young people have extensive knowledge about parental alcohol problems and can demonstrate considerable agency in choosing how to share this knowledge in a research setting. Developing a greater understanding of children's nuanced ways of communicating has implications for research, policy and practice.     

The Moderating Effects of National Age Stereotyping on the Relationships between Job Satisfaction and its Determinants: A Study of Older Workers across 26 Countries

This research explores how national age stereotypes impact older workers' job‐related perceptions by examining probability based samples across 26 countries taken from the European Social Survey. Multilevel data analysis was undertaken. Results show that, at the individual level, both extrinsic rewards and intrinsic rewards directly impact older workers' job satisfaction. At the country level, significant variations are found in the relationships between job satisfaction and related rewards for older workers across the 26 countries. Society's stereotypical views towards older people explained some of these cross‐country variations. This study contributes to extant literature by explicating the process by which society's age stereotypes and the meta‐stereotypes held by older workers affect how these workers make sense and take meaning out of their job‐related circumstances leading to enhanced or diminished job satisfaction. Implications highlight the need for management to be vigilant in identifying and dealing with age stereotypes in the workplace. Furthermore, managers need to be more aware of the potential harmful consequences arising from negative meta‐stereotypes and should implement strategies to tackle workplace stereotypes that would lead to negative meta‐stereotypes held by older workers.     

Two cultures: one life

Recognition of the communal nature of the culture and traditionsof many refugees who have resettled in Australia in recent years,particularly those from African countries, has urged a strongerconsideration of community-based approaches to their recoveryand resettlement. In 2004, a framework of recovery, developedto enhance the mental health and well-being of refugees duringresettlement in Australia, was applied to a community capacity-buildingprogramme among South Sudanese refugees living in an outer westernsuburb of Melbourne. This paper explores the integration ofrecovery goals into the structures and processes initiated throughoutthe programme. It assesses the contribution of this model tostrengthening the community's ability to adjust to resettlementand enable greater control in determining their lives in Australia.     

‘I think I'm more free with them'—Conflict,Negotiation and Change in Intergenerational Relations in African Families Living in Britain

ABSTRACT

While the family is increasingly being recognised as pivotal to migration, there remain too few studies examining how migration impacts on intergenerational relationships. Although traditional intergenerational gaps are intensified by migration, arguably there has been an over-emphasis on the divisions between ‘traditional’ parents and ‘modern’ children at the expense of examining the ways in which both generations adapt. As Foner and Dreby [2011. “Relations Between the Generations in Immigrant Families.” Annual Review of Sociology 37: 545–564] stress, the reality of post-migration intergenerational relations is inevitably more complex, requiring the examination of both conflict and cooperation. This article contributes to this growing literature by discussing British data from comparative projects on intergenerational relations in African families (in Britain, France and South Africa). It argues that particular understandings can be gained from examining the adaptation of parents and parenting strategies post-migration and how the reconfiguration of family relations can contribute to settlement. By focusing on how both parent and child generations engage in conflict and negotiation to redefine their relationships and expectations, it offers insight into how families navigate and integrate the values of two cultures. In doing so, it argues that the reconfiguration of gender roles as a result of migration offers families the space to renegotiate their relationships and make choices about what they transmit to the next generation.     

Internal Migration and Crime in the Soviet Union

This paper analyses the changes in ethnic self-identification of the population of Ukraine from the last (January 1989) Soviet census to the first (December 2001) Ukrainian census. It begins with a comparison of the census data and describes the remarkable changes observed. Given the incomplete nature of published data on international migrations and their differentiation by ethnic groups in the inter-census period, the paper applies a method to fill in the gaps and calculate net migration balances for each ethnic group. Also, since no data is available on the net reproductive rates for separate ethnic groups in Ukraine, it sets out a method to estimate net reproduction rates for Ukrainians and Russians in the inter-census period. Using these methods, it establishes that differences in net migration on the one hand and the differences in net reproduction on the other contributed 11.1 and 4.4 percent of the growth in the share of Ukrainians and 6.8 and 5.2 percent in the sizeable decline in the share of Russians. The remaining lion’s share is a shift in identity among members of ethnically mixed (mainly Russian-Ukrainian) families. Mothers of ethnically mixed families, identifying the ethnicity of their newly born, contributed 11.4 percent to the Ukrainian gain and 9.2 percent to the Russian loss. The remaining 73.1 percent of the Ukrainian gain and 78.8 percent of Russian loss resulted from lifetime identity shift from Russian to Ukrainian, the most likely candidates being members of Russian-Ukrainian families.     

Experience with a criterion for the classification of johnson distributions

We use simulation to investigate the choice of percentiles when using the criterion given by Bowman and Shenton (1989) to select between Johnson's SB and STJ distributions for a data set. We also look at the choice of a tolerance level in classifying distributions as Johnson's SL-