Model diagnostics for marginal regression analysis of correlated binary data

We propose several diagnostic methods for checking the adequacy of marginal regression models for analyzing correlated binary data. We use a parametric marginal model based on latent variables and derive the projection (hat) matrix, Cook's distance, various residuals and Mahalanobis distance between the observed binary responses and the estimated probabilities for a cluster. Emphasized are several graphical methods including the simulated Q-Q plot, the half-normal probability plot with a simulated envelope, and the partial residual plot. The methods are illustrated with a real life example.     

Asymptotic expansions in non-linear renewal theory

We obtain first order asymptotic expansions for the distribution of the excess of a standard normal random walk over a curved boundary and the error probabilities of some repeated significance tests. The key step in the analysis is an asymptotic expansion for the conditional probability that the random walk has not crossed the boundary before the N step, given that it is near the boundary after the n^th step.     

Evaluation of an analysis approach used to account for extra-variation in clustered categorical responses

This article presents the results of a simulation study investigating the performance of an approach developed by Miller and Landis (1991) for the analysis of clustered categorical responses. Evaluation of this “two-step” approach, which utilizes the method of moments to estimate the extra-variation pardmeters and subsequently incorporates these parameters into estimating equations for modelling the marginal expectations, is carried out in an experimental setting involving a comparison between two groups of observations. We assume that data for both groups are collected from each cluster and responses are measured on a three-point ordinal scale. The performance of the estimators used in both “steps” of the analysisis investigated and comparisons are made to an alternative analysismethod that ignores the clustering. The results indicate that in the chosen setting the test for a difference between groups generally operatbs at the nominal α=0.05 for 10 or more clusters and hasincreasing power with both an increasing number of clusters and an inrreasing treatment effect. These results provide a striking contrasc to those obtained from an improper analysis that ignores clustering.     

Tolerance‐based error reduction in multi‐agent bioassays

Some degree of error is inevitable in multi‐agent bioassays regardless of design or measurement technology. Estimation error can be reduced post facto by exploiting the matrix partial ordering of the bioassay survival estimates. The standard method for this is order‐restricted regression (ORR). If the joint action of the bioassay agents admits a tolerance‐based interpretation, additional structure beyond matrix partial ordering is available, leading to a new method of error reduction. This tolerance‐based error reduction (TBER) procedure almost always outperforms ORR. Like ORR, TBER applies to complete factorial bioassay designs and, using weighting, to incomplete designs.     

Using a mixture model for multiple imputation in the presence of outliers: the 'Healthy for life' project

Summary.  We consider the problem of obtaining population-based inference in the presence of missing data and outliers in the context of estimating the prevalence of obesity and body mass index measures from the 'Healthy for life' study. Identifying multiple outliers in a multivariate setting is problematic because of problems such as masking, in which groups of outliers inflate the covariance matrix in a fashion that prevents their identification when included, and swamping, in which outliers skew covariances in a fashion that makes non-outlying observations appear to be outliers. We develop a latent class model that assumes that each observation belongs to one of K unobserved latent classes, with each latent class having a distinct covariance matrix. We consider the latent class covariance matrix with the largest determinant to form an 'outlier class'. By separating the covariance matrix for the outliers from the covariance matrices for the remainder of the data, we avoid the problems of masking and swamping. As did Ghosh-Dastidar and Schafer, we use a multiple-imputation approach, which allows us simultaneously to conduct inference after removing cases that appear to be outliers and to promulgate uncertainty in the outlier status through the model inference. We extend the work of Ghosh-Dastidar and Schafer by embedding the outlier class in a larger mixture model, consider penalized likelihood and posterior predictive distributions to assess model choice and model fit, and develop the model in a fashion to account for the complex sample design. We also consider the repeated sampling properties of the multiple imputation removal of outliers.     

Statistical consulting at German universities: Results of a survey

The article presents the results of a survey on statistical consulting at German universities, where the survey focused on obtaining information on when, where and to whom statistical consulting is provided. We investigate the financial frame of the activity and question the advantages and disadvantages from a consultant’s point of view.     

How planning and capital budgeting improve SME performance

This paper focuses on the use of strategic planning among small and medium sized enterprises (SMEs) in the UK manufacturing sector. It analyses the relationship between the intensity of strategic planning, business objectives, perceived performance, changes in the business environment and the use of capital budgeting techniques. Capital budgeting is of particular interest as an area of investigation, and is one which has seldom featured in previous studies of strategic planning behaviour. These issues were investigated via a survey of UK manufacturing SMEs carried out in the winter of 1996/97.

The key results suggest that SMEs incorporate a range of objectives into their strategic planning process, with profit improvement perceived to be the most important objective, followed by sales growth. SMEs engaged in detailed strategic planning are more likely to use formal capital budgeting techniques, including the net present value method, which is consistent with maximising the companys' value. Perceived profitability and success in achieving organisational objectives were positively associated with planning detail, suggesting that strategic planning is a key component improving performance. Planning detail was also associated with a significantly higher level of perceived change in the business environment.     

The EPA Health Risk Assessment of Methylcyclopentadienyl Manganese Tricarbonyl (MMT)

This paper describes the U.S. Environmental Protection Agency's assessment of potential health risks associated with the possible widespread use of a manganese (Mn)-based fuel additive, methylcyclopentadienyl manganese tricarbonyl (MMT). This assessment was significant in several respects and may be instructive in identifying certain methodological issues of general relevance to risk assessment. A major feature of the inhalation health risk assessment was the derivation of Mn inhalation reference concentration (RfC) estimates using various statistical approaches, including benchmark dose and Bayesian analyses. The exposure assessment component used data from the Particle Total Exposure Assessment Methodology (PTEAM) study and other sources to estimate personal exposure levels of particulate Mn attributable to the permitted use of MMT in leaded gasoline in Riverside, CA, at the time of the PTEAM study; on this basis it was then possible to predict a distribution of possible future exposure levels associated with the use of MMT in all unleaded gasoline. Qualitative as well as quantitative aspects of the risk characterization are summarized, along with inherent uncertainties due to data limitations.     

Rewarding growth or profit?: Top management team compensation and governance in Japanese MNEs

Japanese multinational enterprises (MNEs) have been popularly characterized as pursuing competitive strategies emphasizing long-term performance, especially growth in sales and market share, rather than shorter term profit performance. Though prior research has emphasized the importance of linking compensation to organizational goals and performance, the relationship between performance and compensation of Japanese executives has received limited empirical attention. This paper provides a preliminary examination of how Japanese top management teams in the 106 largest industrial MNEs were compensated, particularly for performance on sales growth and profitability criteria, over the 1976–1993 time period. The relationships revealed between organizational performance and the bonus compensation of top management teams suggest that the emphasis of Japanese industrial MNEs regarding sales growth versus profitability may not be as simple as suggested by prior studies and popular characterizations.