Clinical experience with the new long-acting injectable testosterone undecanoate. Report on the educational symposium on the occasion of the 5th World Congress on the Aging Male, 9–12 February 2006, Salzburg,Austria

This symposium report summarizes first extensive clinical findings with injectable testosterone undecanoate (Nebido®) in hypogonadal patients showing clinical symptoms of androgen deficiency with or without erectile dysfunction (ED). This new testosterone formulation (1000 mg testosterone undecanoate in 4 ml castor oil) possesses nearly ideal long-term kinetics, i.e. sustained close mimicking of eugonadal testosterone serum levels without supra- or sub-physiological serum concentrations. The generally accepted administration scheme recommends the second injection 6 weeks after the first one followed by further injections every 12 weeks. Applying this regimen, administration intervals are drastically reduced in comparison to conventional i.m. testosterone preparations (e.g. about 16 injections of testosterone enanthate vs. 4–5 injections of testosterone undecanoate per year). Depending on the testosterone serum levels, individualized therapy is possible by shortening (every 10 weeks) or prolonging (every 14 weeks) the injection intervals. In hypogonadal patients with ED 58% respond to testosterone undecanoate alone. Best results are seen in diabetic hypogonadal patients. The regimen of injectable testosterone undecanoate administration ideally fits recommendations regarding pharmacokinetics, efficacy and safety monitoring.     

The burden of carcinogenic air toxics among Asian Americans in four US metro areas

Population and Environment - This study investigated disparities in residential exposure to carcinogenic air pollutants among Asian Americans, including Asian ancestry subgroups, in four US metro...     

Small area estimation under unit-level temporal linear mixed models

Data from past time periods and temporal correlation are rich sources of information for estimating small area parameters at the current period. This paper investigates the use of unit-level temporal linear mixed models for estimating linear parameters. Two models are considered, with domain and domain-time random effects. The first model assumes time independency and the second one AR(1)-type time correlation. They are fitted by a Fisher-scoring algorithm that calculates the residual maximum likelihood estimators of the model parameters. Based on the introduced models, empirical best linear unbiased predictors of small area linear parameters are studied, and analytic estimators for evaluating the performance of their mean squared errors are proposed. Three simulation experiments are carried out to study the behaviour of the fitting algorithm, the small area predictors and the estimators of the mean squared error. By using data of the Spanish surveys of income and living conditions of 2004–2008, an application to the estimation of 2008 average normalized net annual incomes in Spanish provinces by sex is given.     

Effect of impact factor and discipline on journal data sharing policies

Data sharing is crucial to the advancement of science because it facilitates collaboration, transparency, reproducibility, criticism, and re-analysis. Publishers are well-positioned to promote sharing of research data by implementing data sharing policies. While there is an increasing trend toward requiring data sharing, not all journals mandate that data be shared at the time of publication. In this study, we extended previous work to analyze the data sharing policies of 447 journals across several scientific disciplines, including biology, clinical sciences, mathematics, physics, and social sciences. Our results showed that only a small percentage of journals require data sharing as a condition of publication, and that this varies across disciplines and Impact Factors. Both Impact Factors and discipline are associated with the presence of a data sharing policy. Our results suggest that journals with higher Impact Factors are more likely to have data sharing policies; use shared data in peer review; require deposit of specific data types into publicly available data banks; and refer to reproducibility as a rationale for sharing data. Biological science journals are more likely than social science and mathematics journals to require data sharing.     

From Social Capital to Inequality: Migrant Networks in Different Stages of Labor Incorporation

How does social capital vary in the distinct stages (prehiring, hiring, and posthiring) of labor incorporation? Based on interviews with 71 Latino migrant workers engaged in residential construction in Las Vegas, Nevada, and 30 transnational migrants who returned to Mexico after working in the United States, I examined two primary issues: first, the structural labor mechanisms that create hyperexploitation, and second, how, in turn, such processes shape social capital. I discovered, at the prehiring phase, social networks connected to subcontractors and those who attempt to form a labor crew function as social capital, despite what may appear to be bonded labor. At the hiring stage, social capital continues to play a role, yet posthiring labor structures create hyperexploitation and immigrants experience inequality in social capital. In such contexts, undocumented Latinos are unable to retain their social capital as U.S. labor structures such as subcontracting and piece‐rate compensation lead to the subjugation of workers, who can become “ghost workers” and bonded laborers. I conclude that in the posthiring stage, such labor structures create what Lin (2000, 2001) refers to as capital deficit and return deficit in social capital that greatly limit the economic incorporation of Latino immigrants.     

Television and identities: analysis of the consumption of ‘telenovelas’ by the Latin American community in Spain

This article analyses the consumption of ‘telenovelas’ by Latin American residents in Spain. Our hypothesis is that ‘telenovelas’ are a way of constructing identities especially in communities that have emigrated to other countries and which can be seen in their specific viewing preferences for fiction. We have carried out a survey following the methodology applied in these kinds of studies. The survey was applied to 219 Latin American subjects who reside in Spain. We demonstrate that the main factors influencing the consumption of ‘telenovelas’ by the Latin American community residing in Spain are related to the cultural identities of the countries of production and which are represented in the context of the different storylines, such as natural locations, costumes and language. The results show that further research in this field is needed in order to identify the derivations of perceptions by the immigrant collectives through successful products such as ‘telenovelas’.     

Spanish adaptation of the Antifat Attitudes Scale / Adaptación al castellano de la Escala de Actitud Antiobesos

Antifat attitudes may be defined as the negative assessment of people with weight problems. To evaluate them, the Antifat Attitudes Scale (AFA) has been used in most studies. The aim of this study is to adapt the AFA questionnaire to the Spanish population. The sample was made up of 1,457 university students from all over Spain. Exploratory and confirmatory factor analyses showed that the items on the questionnaire fit a three-factor model corresponding to the three dimensions proposed by the original author (dislike, fear of fat and willpower) and that they are interrelated. In light of these results, we conclude that the questionnaire is methodologically valid and can be used by the scientific community to measure antifat attitudes.     

Analysing the effect of public health campaigns on reducing excess weight: a modelling approach for the Spanish Autonomous Region of the Community of Valencia

Excess weight is fast becoming a serious health concern in the developed and developing world. The concern of the public health sector has lead to the development of public health campaigns, focusing on two-fold goals: to inform the public as to the health risks inherent in being overweight, and the benefits of a change in nutritional behaviour. Recent studies indicate that the effects of the average public health campaign on the target community is around 5%. In this study we aim to quantify the effect of different public health campaigns on lifestyle behaviour in the target populations in order to bring about weightloss in a significant number of people over the next few years.This study is based on recent works that consider excess weight as a consequence of the transmission of unhealthy lifestyles from one individual to another. Following this point of view, first a mathematical model is presented. Then, policies based on public health campaigns addressed to stop people gaining weight (prevention; this type of policy acts on individuals in order to maintain their weight and to stop an increase in weight) and, policies addressed to overweight individuals to reduce their weight (treatment; these campaigns act on overweight and/or obese individuals in order to reduce their weight) are simulated in order to evaluate their effectiveness. The study concludes that combination of preventive plus treatment campaigns are more effective than considering them separately.     

Small area estimation of expenditure means and ratios under a unit-level bivariate linear mixed model

Under a unit-level bivariate linear mixed model, this paper introduces small area predictors of expenditure means and ratios, and derives approximations and estimators of the corresponding mean squared errors. For the considered model, the REML estimation method is implemented. Several simulation experiments, designed to analyze the behavior of the introduced fitting algorithm, predictors and mean squared error estimators, are carried out. An application to real data from the Spanish household budget survey illustrates the behavior of the proposed statistical methodology. The target is the estimation of means of food and non-food household annual expenditures and of ratios of food household expenditures by Spanish provinces.