Statistical methodology for assessing homology of intronic regions of genes

We consider the problem of statistically evaluating the similarity of DNA intronic regions of genes. Present algorithms are based on matching a sequence of interest with known DNA sequences in a gene bank and are designed primarily to assess homology among exonic regions of genes. Most research focuses on exonic regions because they have a clear biological significance, coding for proteins, and therefore tend to be more conserved in evolution than intronic regions. To investigate whether the intronic features of genes whose expression is highly sensitive to environmental perturbations differ from genes that have a more constant expression, a collection of oncogenes, tumor suppressor genes, and nonregulatory genes involved in energy metabolism are compared. An analysis of the features of these genes' intronic regions result in clustering by regulatory group. In addition, Billingsley's test for Markov structure (1961) suggests that 67% of the intronic regions in this collection of genes show evidence of nonrandom structure, indicating the possibility of a biological function for these regions. The result of Billingsley's test for homology is used as input to a clustering algorithm. The biological significance of this methodology lies in the identification of groups based on the intronic regions from genes of unknown function. With the advent of rapid sequencing techniques, there is a great need for statistical techniques to help identify the purpose of poorly understood portions of genes. These methods can be utilized to assess the functional group to which such a gene might possibly belong.     

Dynamic Pricing to Minimize Maximum Regret

We consider a dynamic pricing problem that involves selling a given inventory of a single product over a short, two‐period selling season. There is insufficient time to replenish inventory during this season, hence sales are made entirely from inventory. The demand for the product is a stochastic, nonincreasing function of price. We assume interval uncertainty for demand, that is, knowledge of upper and lower bounds but not a probability distribution, with no correlation between the two periods. We minimize the maximum total regret over the two periods that results from the pricing decisions. We consider a dynamic model where the decision maker chooses the price for each period contingent on the remaining inventory at the beginning of the period, and a static model where the decision maker chooses the prices for both periods at the beginning of the first period. Both models can be solved by a polynomial time algorithm that solves systems of linear inequalities. Our computational study demonstrates that the prices generated by both our models are insensitive to errors in estimating the demand intervals. Our dynamic model outperforms our static model and two classical approaches that do not use demand probability distributions, when evaluated by maximum regret, average relative regret, variability, and risk measures. Further, our dynamic model generates a total expected revenue which closely approximates that of a maximum expected revenue approach which requires demand probability distributions.     

Le maire en action : gouvernement urbain et production de politiques publiques. Michel Delebarre à Dunkerque

Changes in the French political, administrative system and trends in the economy starting in the 1970s have reshaped power at the municipal level. The figure of the mayor as a “notable” has apparently taken a more entrepreneurial and managerial turn in line with changes in local government, its sources of revenue and contractual procedures. By studying the mayor through the prism of the production of public policy at the local level, this shift can be qualified: the role as a notable is tapped in mobilizing resources, while the dynamic entrepreneurial role comes into play in steering policies, timing interventions and assessing the related risks. The observation of the whole process of producing the two urban policies described in Dunkerque sheds light on how the “municipal team” led by the mayor defines the rules of the game, takes diverging interests into account and maintains an interdependence between the various actors involved in policy-implementation. This article seeks to open a dialog between a case study of a municipal government and the observation of local public policy so as to understand changes in the levers of local power.     

The Johnson Typologies of Intimate Partner Violence: An Investigation of Their Representation in a General Population of New Zealand Women

Typologies of intimate partner violence (IPV) can inform practice and aid with the development of interventions. To maintain utility, typologies should be constantly reviewed in light of emerging results generated from internal and external validation. The presented study is an empirical exploration of the M. P. Johnson (2008 Johnson, M. P. (2008). A typology of domestic violence: Intimate terrorism, violent resistance, and situational couple violence. Boston, MA: Northeastern University Press. [Google Scholar]) typology of IPV using data gathered from the New Zealand replication of the World Health Organization Violence Against Women survey. We could not identify all types of IPV described by Johnson, and we suggest that mutually exclusive types of violent relationships do not exist. Further exploration of the validity of the Johnson typologies, including an exploration of the utility of categorization for suggesting appropriate responses to IPV, is required.     

Estimating the prevalence of adolescent gambling disorders: A quantitative synthesis and guide toward standard gambling nomenclature

This article reviews the extant published and unpublished studies that estimate the prevalence of adolescent gambling problems in North America. The nine nonduplicative studies identified by our literature search included data collected from more than 7700 adolescents from five different regions of the United States and Canada. In addition to comparing the conceptual and methodological differences that exist among these studies, this article employed a meta-analytic strategy to synthesize prevalence estimates from the existing studies. This analysis revealed that within a 95 percent confidence interval, between 9.9% and 14.2% of adolescents are at risk of developing or returning to serious gambling problems. Similarly, between 4.4% and 7.4% of adolescents exhibit seriously adverse compulsive or pathological patterns of gambling activity. Finally, the discussion proposes a generic multi-level classification scheme to reconcile the divergent classification methods and data reporting strategies. This new multi-level approach to reporting gambling prevalence will facilitate interstudy comparisons among existing estimates of gambling prevalence and help to provide a general data reporting system for future research.     

如何发明

深圳长期以来被称作是全球制造业中心,而且它已经得到了联合国教科文组织"设计之都"的称号,我想深圳的下一个目标就是建立一个"创新之都".不知道我是否有资格在这里建议深圳这样一个大城市怎样更具创意,如果要我提建议的话,我会让大家考虑一些边界模糊的设计,把一些不寻常的东西结合起来,尽量保持多学科的融合,因为创新来自予内部.     

The Corporate University and social work academic roles

Abstract

Universities have undergone significant changes in the last decade. Universities have become ‘corporate’, integrating the values, assumptions and ethics of corporate economic capitalism. Within universities, social work practice expertise is negated as a criterion of valued ‘technological role expertise’ of social work academics. The paper describes and analyses the compounding impact of changes in the role of universities upon the historically problematic relationship between social work practice and social work education, The paper suggests a means to integrate both roles in the roles of practitioner-academic and academic-practitioner A typology is developed which identifies the knowledge and skill basis of social work practitioners and academics. The typology enables an identification of the cross fertilisation of each role on the practice expertise of the other. Through such a typology an alternative valued criterion of ‘technological role expertise’ can be established by the profession itself for utilisation in both academic and practice appointments and promotion assessment.     

The Joint Effects of Offender Race/Ethnicity and Sex on Sentence Length Decisions in Federal Courts

The current study examined the main and interactive effects of offender race/ethnicity and sex on sentence length decisions for drug offenders convicted in three federal courts located in Iowa, Minnesota, and Nebraska. The additive model showed that females received shorter prison sentences than similarly situated male offenders, but there were no differences between white offenders and minority offenders. However, when the data were partitioned by sex, black males were found to receive lengthier prison terms than white males. There were no differences between white males and Hispanic males, and white females were treated no differently than either black or Hispanic females. Moreover, when the data were partitioned by race/ethnicity, white females were treated no differently than white males. However, black females received shorter sentences than black males and Hispanic females received shorter sentences than Hispanic males. Further analyses showed that black and Hispanic males also received longer sentences than white females and that black males received longer sentences than all other offenders (with the exception of Hispanic male offenders). These findings mesh with those gleaned from other sentencing studies, although they are at odds with theoretical notions that leniency at the sentencing stage is reserved only for white women.