Physiologically Based Liver Modeling and Risk Assessment

Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments.     

Premarital Cohabitation and Housework: Couples in Cross‐National Perspective

The authors examine the effect of premarital cohabitation on the division of household labor in 22 countries. First, women do more routine housework than men in all countries. Second, married couples that cohabited before marriage have a more equal division of housework. Third, national cohabitation rates have equalizing effects on couples regardless of their own cohabitation experience. However, the influence of cohabitation rates is only observed in countries with higher levels of overall gender equality. The authors conclude that the trend toward increasing cohabitation may be part of a broader social trend toward a more egalitarian division of housework.     

'Making Culture Matter': Symbolic,Spatial and Social Boundaries between Uyghurs and Han Chinese

This article illustrates how Uyghurs in the 1990s defined and reinforced contemporary Uyghur national identity in relation to Xinjiang's growing Han Chinese population. Adopting Barth's theory of fluid and negotiable ethnic boundaries, it focuses on the notion of change. While Uyghurs are currently activating and exaggerating certain religio-cultural differences--in particular the avoidance of pork--as a means of ensuring symbolic, spatial and social segregation from the Han, those criteria did not prevent interaction to the same extent in the past; nor do they prevent Uyghurs from making concessions when it benefits them to do so. It is argued that it is not religio-cultural differences per se that lie at the root of increased tensions between Uyghurs and Han Chinese, but changing social, political and economic contexts: on the one hand, growing Uyghur perceptions of socio-economic inequalities between themselves and the Han (the 'internal factor') and, on the other, the vast changes within the international political arena since the late 1980s (the 'external factor').     

Self-defense training for college women.

This article explores the effectiveness of self-defense training for college women. Advocates of self-defense training believe these courses will not only provide women with the physical survival techniques necessary to repel attacks effectively, but that this kind of training will also help to prevent future violence by developing traits such as assertiveness and confidence in individuals. There is evidence that women who convey such characteristics are less likely to be victimized. Opponents argue that self-defense training does not properly prepare women for an attack, does not adequately address acquaintance rape threats, and can provide a dangerous false sense of security to students. This article reviews the relevant literature, outlines practical suggestions for initiatives in this area, and describes a model self-defense course at one university. Guidelines for evaluation and implications for university policy and program decisions that address violence against women on college campuses are included.     

Designing ChSP-4(c1, c2) plans

In this paper, the notion of average total inspection (ATI) is introduced to ChSP-4(c1,c2) sampling plans. Procedures have been developed for the construction and selection of ChSP-4(c1, c2 plans, minimizing ATI at a given process average, while protection to the consumer is given in terms of the (i) average outgoing quality limit and (ii) limiting quality level.A wide range of c1 and c2 values are considered for developing tables which cover almost all practical situations. The procedure described is similar to that of Dodge and Romig.     

Surname analysis for estimating local concentration of Hispanics and Asians

Surname analysis is a potentially useful technique for identifying members of particular racial, ethnic, or language communities within a population. We review the existing state of the art for identifying persons of Hispanic or Asian origin, based on surnames distinctive of each group. We describe the logic of surname analysis, profile several available surname dictionaries, and illustrate their applications in local redistricting. Results of our ongoing validation studies suggest promising future directions for improving accuracy and broadening applications.This article is based on a paper presented at the annual Population Association of America meetings at Cincinnati, 1 April 1993.     

Race and prevailing wage laws in the construction industry: Comment on Thieblot

Using the 1990 Census of Population, Thieblot (1999) argued that black employment and the strength of the prevailing wage laws are correlated and that repeal of these laws would lead to higher black employment in construction. Analysis of the 1970 Census of Population reveals that the relative abundance of black construction workers in the group of states that eventually would repeal their laws preceded those repeals and that this is mainly due to the characteristics of Southern labor markets. This and other research cast doubt on both the strength and the existence of such a correlation.