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341.
Stephen V. Jacobs Gary W. Evans Ralph Catalano David Dooley 《Population and environment》1984,7(4):260-272
Exploratory modelling revealed associations of individual perceptions, social factors, and physical components of air pollution with depressive symptomatology. Residents of the Los Angeles Metropolitan Area who have experienced a recent, undesirable life event and who perceive poor air quality in their neighborhood have greater symptoms of depression. These effects control for socioeconomic status and prior psychological status. In addition we show that perceived air quality is a function of both toxic components of ambient air as well as individual psychosocial experiences.This research was supported by the National Institute for Mental Health (MH 28924-10A1) and the Southern California Edison Health Effects Research Laboratory (J-1909902). We thank Jean Ospital, Len Edwards, and Julian Foon for their assistance. Reprint requests should be sent to Gary Evans, Program in Social Ecology, University of California, Irvine, CA 92717. 相似文献
342.
Istvan M. Majer Ralph Stevens Wilma J. Nusselder Johan P. Mackenbach Pieter H. M. van Baal 《Demography》2013,50(2):673-697
Life expectancy continues to grow in most Western countries; however, a major remaining question is whether longer life expectancy will be associated with more or fewer life years spent with poor health. Therefore, complementing forecasts of life expectancy with forecasts of health expectancies is useful. To forecast health expectancy, an extension of the stochastic extrapolative models developed for forecasting total life expectancy could be applied, but instead of projecting total mortality and using regular life tables, one could project transition probabilities between health states simultaneously and use multistate life table methods. In this article, we present a theoretical framework for a multistate life table model in which the transition probabilities depend on age and calendar time. The goal of our study is to describe a model that projects transition probabilities by the Lee-Carter method, and to illustrate how it can be used to forecast future health expectancy with prediction intervals around the estimates. We applied the method to data on the Dutch population aged 55 and older, and projected transition probabilities until 2030 to obtain forecasts of life expectancy, disability-free life expectancy, and probability of compression of disability. 相似文献
343.
Statistical methods of risk assessment for continuous variables 总被引:1,自引:0,他引:1
Adverse health effects for continuous responses are not as easily defined as adverse health effects for binary responses. Kodell and West (1993) developed methods for defining adverse effects for continuous responses and the associated risk. Procedures were developed for finding point estimates and upper confidence limits for additional risk under the assumption of a normal distribution and quadratic mean response curve with equal variances at each dose level. In this paper, methods are developed for point estimates and upper confidence limits for additional risk at experimental doses when the equal variance assumption is relaxed. An interpolation procedure is discussed for obtaining information at doses other than the experimental doses. A small simulation study is presented to test the performance of the methods discussed. 相似文献
344.
At least two computer program packages, SPSS and STRATA, use simulated Bernoulli trials to draw (without replacement) a random sample of records from a finite population of records. Therefore, the size of the sample is a random variable. Two estimators of a population total under this sampling procedure are compared with the usual estimator under simple random sampling. Conditions under which the Bernoulli sampling estimators have almost the same mean squared error as the simple random-sample estimator are illustrated. 相似文献
345.
Developmental neurotoxicity concerns the adverse health effects of exogenous agents acting on neurodevelopment. Because human brain development is a delicate process involving many cellular events, the developing fetus is rather susceptible to compounds that can alter the structure and function of the brain. Today, there is clear evidence that early exposure to many neurotoxicants can severely damage the developing nervous system. Although in recent years, there has been much attention given to model development and risk assessment procedures for developmental toxicants, the area of developmental neurotoxicity has been largely ignored. Here, we consider the problem of risk estimation for developmental neurotoxicants from animal bioassay data. Since most responses from developmental neurotoxicity experiments are nonquantal in nature, an adverse health effect will be defined as a response that occurs with very small probability in unexposed animals. Using a two-stage hierarchical normal dose-response model, upper confidence limits on the excess risk due to a given level of added exposure are derived. Equivalently, the model is used to obtain lower confidence limits on dose for a small negligible level of risk. Our method is based on the asymptotic distribution of the likelihood ratio statistic (cf. Crump, 1995). An example is used to provide further illustration. 相似文献
346.
A major issue in value-function assessment is the possibility of receiving an indefinite response from a decision maker to a question about preferences. The conventional treatment requires a single, definite response from the decision maker. This approach either assumes that response error is zero or accepts the final solution as only approximate, without knowing how approximate it might be. In this paper we examine the issue of indefinite responses, define it more precisely, and present a method for incorporating it into decision making. The method is adaptive in that it is iterative and interactive with the decision maker who, at each iteration, is provided with information regarding the potential advantage of answering more trade-off questions and/or answering questions more carefully to reduce response error. In contrast to other approaches that “force” rationality and decisiveness, we work with irrationality and indecisiveness on the part of the decision maker. The method is demonstrated for the case of concave, increasing value functions. 相似文献