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151.
The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical
data are intrinsically stochastic and tend to be observed by means of discrete-time sampling systems, which are often limited
in their completeness. In this paper we explore how to make Bayesian inference for the kinetic rate constants of regulatory
networks, using the stochastic kinetic Lotka-Volterra system as a model. This simple model describes behaviour typical of
many biochemical networks which exhibit auto-regulatory behaviour. Various MCMC algorithms are described and their performance
evaluated in several data-poor scenarios. An algorithm based on an approximating process is shown to be particularly efficient. 相似文献
152.
153.
This study examined the emergence of affect specificity in infancy. In this study, infants received verbal and facial signals of 2 different, negatively valenced emotions (fear and sadness) as well as neutral affect via a television monitor to determine if they could make qualitative distinctions among emotions of the same valence. Twenty 12‐ to 14‐month‐olds and 20 16‐ to 18‐month‐olds were examined. Results suggested that younger infants showed no evidence of referential specificity, as they responded similarly to both the target and distracter toys, and showed no evidence of affect specificity, showing no difference in play between affect conditions. Older infants, in contrast, showed evidence both of referential and affect specificity. With respect to affect specificity, 16‐ to 18‐month‐olds touched the target toy less in the fear condition than in the sad condition and showed a larger proportion of negative facial expressions in the sad condition versus the fear condition. These findings suggest a developmental emergence after 15 months of age for affect specificity in relating emotional messages to objects. 相似文献
154.
D. R. Cox 《Journal of the Royal Statistical Society. Series A, (Statistics in Society)》2003,166(2):241-246
Summary. Possible health hazards from mobile phones arise from the use of the phones themselves and via the base stations that relay signals. Except for an increase in traffic accidents induced by the use of mobile phones in cars the evidence for a health hazard is at most indirect, but it cannot be entirely dismissed; the phones have not been widely used for sufficiently long for direct epidemiological studies to have high sensitivity for detecting any induced incidence of cancer, for example. The background and evidence are briefly reviewed and the steps taken in the UK to make information widely available described. 相似文献
155.
The Alchian and Allen theorem predicts that it will be harder to find "good" apples in the State of Washington, a prime apple-growing region, than in, say, New York City, where the addition of shipping charges makes "bad" apples comparatively more expensive. We recast the theorem as a testable proposition by explicitly taking the supply side into account and identifying plausible scenarios in which a fixed cost either has no effect on the relative prices of high and low quality grades of the same good in distant markets or, indeed, causes more of the bad apples to be shipped out. 相似文献
156.
This paper studies optimum designs for linear models when the errors are heteroscedastic. Sufficient conditions are given
in order to obtainD-, A- andE-optimum designs for a complete regression model from partial optimum designs for some sub-parameters. A result about optimality
for a complete model from the optimality for the submodels is included.
Supported by Junta de Andalucía, research group FQM244. 相似文献
157.
158.
Dwight R. Lee 《Journal of Labor Research》2003,24(3):437-446
Reverse mandated benefits is a government-mandated policy that requires employees to provide their employers with benefits
that workers would not provide otherwise. Of course, only those benefits would be mandated that are worth more to employers
than they cost, as determined by political authorities. My case for such a policy argues that it is at least as sensible as
policies mandating that employers provide benefits to their employees that would not be provided otherwise. 相似文献
159.
This paper investigates how individuals evaluate delayed outcomes with risky realization times. Under the discounted expected utility (DEU) model, such evaluations depend only on intertemporal preferences. We obtain several testable hypotheses using the DEU model as a benchmark and test these hypotheses in three experiments. In general, our results show that the DEU model is a poor predictor of intertemporal choice behavior under timing risk. We found that individuals are averse to timing risk and that they evaluate timing lotteries in a rank-dependent fashion. The main driver of timing risk aversion is nothing but probabilistic risk aversion that stems from the nonlinear treatment of probabilities. 相似文献
160.
1. Research shows that many emergency workers are affected physically and emotionally by critical incident stress. 2. Debriefings conducted by trained team members are an effective method to mitigate the impact of critical incident stress. A debriefing is a structured, time-limited group intervention. 3. Cooperation among community agencies is essential for the development and effective functioning of a critical incident stress debriefing team. 4. Several teams in Illinois have organized to form a Critical Incident Stress Debriefing Network. The Illinois network is part of an international organization composed of critical incident stress debriefing providers. 相似文献