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71.
This article is based on research undertaken among South African chief executives occupying the most senior operational positions in public-quoted companies. In looking at distinctive characteristics in these individuals the research attempts to bring together the activities that shape the chief executive's job and explore possible trends in their background; career route and behaviour patterns, and from the compositie picture to provide guidelines for executive development.  相似文献   
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This paper derives from an ongoing research project concerned to explore how people living in, going to work in, attending school in, high crime areas manage their routine daily lives. It focuses on one of our research areas in which we argue that the question of the 'fear of crime' is much better understood through an appreciation of how the question of trust manifests itself in that community. In other words, whom you trust, when, and by how much, mediate the way in which people living in this area manage their routine daily lives and within that their sense of security.  相似文献   
76.
Models of Neurotoxicity: Extrapolation of Benchmark Doses in Vitro   总被引:4,自引:0,他引:4  
In risk assessment, no observed exposure level (NOAEL) and benchmark dose (BMD) are usually derived either from epidemiological studies in humans or from animal experiments. In many in vitro studies, concentration-effect/response curves have been analyzed using different mathematical models finalized to the identification of EC50. In the present article, we propose a model to fit dose-response curves in vitro. The BMD approach has been used to compare the cell viability (MIT assay) of different rat (C6 and PC12, glial and neuronal, respectively) and human cell lines (D384 and SK-N-MC, glial and neuronal, respectively) after 24-hour exposure to the following neurotoxic substances: manganese chloride (MnCl2), methyl-mercury (Me-Hg), and the enantiomers of styrene oxide (SO). For all rat and human cell lines, the potency of the examined compounds was: MnCl2 < S-SO < R-SO < Me-Hg. A preliminary comparison with in vivo toxicity data for these substances gave rise to consistent results. Whereas a reasonable agreement between in vitro and in vivo data has been found for Mn and styrene oxide, a wide scatter of LOAEL has been reported for Me-Hg and these appear to be either much higher or lower than the BMD for the MIT assay we observed in vitro.  相似文献   
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Summary Factor models can cope with many variables without running into scarce degrees of freedom problems often faced in a regression-based analysis. In this article we review recent work on dynamic factor models that have become popular in macroeconomic policy analysis and forecasting. By means of an empirical application we demonstrate that these models turn out to be usefu in investigating macroeconomic problems.  相似文献   
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The concept of ‘fuel poverty’, the inability to afford adequate warmth at home has become a focus for social policies in recent years. Increasing numbers of households dependent on social security and the likelihood that fuel will become more expensive mean that the existing problem of fuel poverty may become even greater. The data on fuel expenditure and related variables from three national surveys are used to evaluate various policy options for relieving fuel poverty. Three policies for increasing incomes to pay for fuel costs are considered, increasing benefits, introducing a fuel allowance or extending the existing scheme of additional heating requirements. The policies for reducing fuel expenditure are also considered, restructuring tariffs, changing payment methods and conservation measures. The case is made for priority to be given to an advice and information campaign and a conservation programme aimed at poor households who are unable to respond to existing price signals and grants.  相似文献   
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The authors report a case of multiple personality in which therapy was directed at the marital couple, rather than focusing on the multiple personality per se. The symptoms of the individual are seen as a disturbance in the family homeostasis and were treated from that standpoint. The functions of the symptom in the areas of impulse discharge, superego operation, boundaries of closeness-distance, and self-object representations for the couple and family are discussed.  相似文献   
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