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Prolapse is an extremely common condition, for which 11% of women will have a surgical procedure at some point in their lives. The recurrence rate after most of the traditional surgical procedures is high and upto 29% of women who have had surgery for prolapse will require a further operation. In order to improve the surgical outcome, there is currently much interest in the use of grafts to augment traditional repairs and new procedures have been developed using specifically developed grafts. These have been combined with minimally invasive surgical techniques in an attempt to reduce surgical morbidity. These procedures may improve the outcome of surgery for prolapse. However, there is currently a lack of long-term data from randomized trials to demonstrate their effectiveness and safety.  相似文献   
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Johan A. Oldekop  Lorenza B. Fontana  Jean Grugel  Nicole Roughton  Emmanuel A. Adu‐Ampong  Gemma K. Bird  Alex Dorgan  Marcia A. Vera Espinoza  Sara Wallin  Daniel Hammett  Esther Agbarakwe  Arun Agrawal  Nurgul Asylbekova  Clarissa Azkoul  Craig Bardsley  Anthony J. Bebbington  Savio Carvalho  Deepta Chopra  Stamatios Christopoulos  Emma Crewe  Marie‐Claude Dop  Joern Fischer  Daan Gerretsen  Jonathan Glennie  William Gois  Mtinkheni Gondwe  Lizz A. Harrison  Katja Hujo  Mark Keen  Roberto Laserna  Luca Miggiano  Sarah Mistry  Rosemary J. Morgan  Linda L. Raftree  Duncan Rhind  Thiago Rodrigues  Sonia Roschnik  Flavia Senkubuge  Ian Thornton  Simon Trace  Teresa Ore  Ren Mauricio Valds  Bhaskar Vira  Nicola Yeates  William J. Sutherland 《Development policy review : the journal of the Overseas Development Institute》2016,34(1):55-82
The Sustainable Development Goals (SDGs) herald a new phase for international development. This article presents the results of a consultative exercise to collaboratively identify 100 research questions of critical importance for the post‐2015 international development agenda. The final shortlist is grouped into nine thematic areas and was selected by 21 representatives of international and non‐governmental organisations and consultancies, and 14 academics with diverse disciplinary expertise from an initial pool of 704 questions submitted by 110 organisations based in 34 countries. The shortlist includes questions addressing long‐standing problems, new challenges and broader issues related to development policies, practices and institutions. Collectively, these questions are relevant for future development‐related research priorities of governmental and non‐governmental organisations worldwide and could act as focal points for transdisciplinary research collaborations.  相似文献   
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The study aimed to identify different patterns of gambling activities (PGAs) and to investigate how PGAs differed in gambling problems, substance use outcomes, personality traits and coping strategies. A representative sample of 4989 young Swiss males completed a questionnaire assessing seven distinct gambling activities, gambling problems, substance use outcomes, personality traits and coping strategies. PGAs were identified using latent class analysis (LCA). Differences between PGAs in gambling and substance use outcomes, personality traits and coping strategies were tested. LCA identified six different PGAs. With regard to gambling and substance use outcomes, the three most problematic PGAs were extensive gamblers, followed by private gamblers, and electronic lottery and casino gamblers, respectively. By contrast, the three least detrimental PGAs were rare or non-gamblers, lottery only gamblers and casino gamblers. With regard to personality traits, compared with rare or non-gamblers, private and casino gamblers reported higher levels of sensation seeking. Electronic lottery and casino gamblers, private gamblers and extensive gamblers had higher levels of aggression-hostility. Extensive and casino gamblers reported higher levels of sociability, whereas casino gamblers reported lower levels of anxiety–neuroticism. Extensive gamblers used more maladaptive and less adaptive coping strategies than other groups. Results suggest that gambling is not a homogeneous activity since different types of gamblers exist according to the PGA they are engaged in. Extensive gamblers, electronic and casino gamblers and private gamblers may have the most problematic PGAs. Personality traits and coping skills may predispose individuals to PGAs associated with more or less negative outcomes.  相似文献   
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It is the purpose of this paper to make explicit the methodology (the theory of the methods) by which we conducted research for an Economic and Social Research Council-funded research project on the relationship of values to value. Specifically, we wanted to study the imperative of Facebook to monetize social relationships, what happens when one of our significant forms of communication is driven by the search for profit, by the logic of capital. We therefore wanted to ‘get inside’ and understand what capital's new lines of flight, informationally driven models of economic expansion, do to social relations. Taking up the challenge to develop methods appropriate to the challenges of ‘big data', we applied four different methods to investigate the interface that is Facebook: we designed custom software tools, generated an online survey, developed data visualizations, and conducted interviews with participants to discuss their understandings of our analysis. We used Lefebvre's [(2004). Rhythmnanalysis: Space, time and everyday life. London: Continuum] rhythmanalysis and Kember and Zylinska's [(2012). Life after new media: Mediation as a vital process. Cambridge, MA: MIT Press] ideas about ‘lifeness’ to inform our methodology. This paper reports on a research process that was not entirely straightforward. We were thwarted in a variety of ways, especially by challenge to use software to study software and had to develop our project in unanticipated directions, but we also found much more than we initially imagined possible. As so few academic researchers are able to study Facebook through its own tools (as Tufekci [(2014 Tufekci, Z. (2014). Big questions for social media big data: Representativeness, validity and other methodological pitfalls. In ICWSM 14: Proceedings of the 8th International AAAI Conference on Weblogs and Social Media, pp. 505–514. [Google Scholar]). Big questions for social media big data: Representativeness, validity and other methodological pitfalls. In ICWSM ‘14: Proceedings of the 8th International AAAI Conference on Weblogs and Social Media (pp. 505–514)] notes how, unsurprisingly, at the 2013 ICWSM only about 5% of papers were about Facebook and nearly all of these were co-authored with Facebook data scientists), we hope that our methodology is useful for other researchers seeking to develop less conventional research on Facebook.  相似文献   
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