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101.
Individuals’ perceptions and their interpersonal communication about a risk event, or risk talk, can play a significant role in the formation of societal responses to the risk event. As they formulate their risk opinions and speak to others, risk information can circulate through their social networks and contribute to the construction of their risk information environment. In the present study, Japanese citizens’ risk perception and risk talk were examined in the context of the Fukushima Daiichi nuclear radiation risk. We hypothesized and found that the risk information environment and risk literacy (i.e., competencies to understand and use risk information) interact to influence their risk perception and risk talk. In particular, risk literacy tends to stabilize people's risk perceptions and their risk communications. Nevertheless, there were some subtle differences between risk perception and communication, suggesting the importance of further examination of interpersonal risk communication and its role in the societal responses to risk events.  相似文献   
102.
Model‐based phase I dose‐finding designs rely on a single model throughout the study for estimating the maximum tolerated dose (MTD). Thus, one major concern is about the choice of the most suitable model to be used. This is important because the dose allocation process and the MTD estimation depend on whether or not the model is reliable, or whether or not it gives a better fit to toxicity data. The aim of our work was to propose a method that would remove the need for a model choice prior to the trial onset and then allow it sequentially at each patient's inclusion. In this paper, we described model checking approach based on the posterior predictive check and model comparison approach based on the deviance information criterion, in order to identify a more reliable or better model during the course of a trial and to support clinical decision making. Further, we presented two model switching designs for a phase I cancer trial that were based on the aforementioned approaches, and performed a comparison between designs with or without model switching, through a simulation study. The results showed that the proposed designs had the advantage of decreasing certain risks, such as those of poor dose allocation and failure to find the MTD, which could occur if the model is misspecified. Copyright © 2013 John Wiley & Sons, Ltd.  相似文献   
103.
Yamato Transport Corporation recently entered the parcels business and has been very successful, taking the largest share of the market, in competition with the Japanese Post Office. By the use of a computerized information system, the company provides a rapid high quality service. Yamoto offers a pick up and delivery service. It uses retail stores for receiving the parcels and every driver has a small ‘point of sale’ terminal. The company has built its transportation network systematically, one step at a time.  相似文献   
104.
105.
For square contingency tables that have nominal categories, Tomizawa considered two kinds of measure to represent the degree of departure from symmetry. This paper proposes a generalization of those measures. The proposed measure is expressed by using the average of the power divergence of Cressie and Read, or the average of the diversity index of Patil and Taillie. Special cases of the proposed measure include Tomizawa's measures. The proposed measure would be useful for comparing the degree of departure from symmetry in several tables.  相似文献   
106.
北京和东京居民的时间分配比较研究   总被引:1,自引:0,他引:1  
本文以时间作为测量人类生活的计量单位,运用北京和东京两市居民的生活时间分配调查资料,对北京和东京两市居民的生活时间分配以及变动趋势进行了比较研究,反映了两市居民的生活方式的差异及其变化,探讨了形成这些差异和变化的主要原因。  相似文献   
107.
How does the development of collaborative research networks vary? This paper investigates how research networks have developed in the same technological fields in North America, Europe, and Asia. Exploring inter-organizational co-authored papers published in the Applied Physics Letters from 1975 to 1994, we first map the collaborative research networks and demonstrate that research networks were more developed in scale and scope in North America than in Europe and Asia in semiconductor laser technology. U.S. organizations played a nodal role in networking throughout this time period. Addressing how research networks were more developed in the U.S. than in Japan in particular, this paper concludes that engineer mobility, academic–industry relationships, and entrepreneurial startups were the key factors for the development of collaborative networks during the periods studied.  相似文献   
108.
ABSTRACT

This paper reviews and extends the literature on the finite sample behavior of tests for sample selection bias. Monte Carlo results show that, when the “multicollinearity problem” identified by Nawata (1993 Nawata , K. ( 1993 ). A note on the estimation of models with sample-selection biases . Economics Letters 42 : 1524 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] [Google Scholar]) is severe, (i) the t-test based on the Heckman–Greene variance estimator can be unreliable, (ii) the Likelihood Ratio test remains powerful, and (iii) nonnormality can be interpreted as severe sample selection bias by Maximum Likelihood methods, leading to negative Wald statistics. We also confirm previous findings (Leung and Yu, 1996 Leung , S. F. , Yu , S. ( 1996 ). On the choice between sample selection and two-part models . Journal of Econometrics 72 : 197229 . [CSA] [CROSSREF] [Crossref], [Web of Science ®] [Google Scholar]) that the standard regression-based t-test (Heckman, 1979 Heckman , J. J. ( 1979 ). Sample selection bias as a specification error . Econometrica 47 : 153161 . [CSA] [Crossref], [Web of Science ®] [Google Scholar]) and the asymptotically efficient Lagrange Multiplier test (Melino, 1982 Melino , A. ( 1982 ). Testing for sample selection bias . Review of Economic Studies 49 : 151153 . [CSA] [Crossref], [Web of Science ®] [Google Scholar]), are robust to nonnormality but have very little power.  相似文献   
109.
Clinical trials with event‐time outcomes as co‐primary contrasts are common in many areas such as infectious disease, oncology, and cardiovascular disease. We discuss methods for calculating the sample size for randomized superiority clinical trials with two correlated time‐to‐event outcomes as co‐primary contrasts when the time‐to‐event outcomes are exponentially distributed. The approach is simple and easily applied in practice. Copyright © 2012 John Wiley & Sons, Ltd.  相似文献   
110.
The clinical efficacy of a new treatment may often be better evaluated by two or more co-primary endpoints. Recently, in pharmaceutical drug development, there has been increasing discussion regarding establishing statistically significant favorable results on more than one endpoint in comparisons between treatments, which is referred to as a problem of multiple co-primary endpoints. Several methods have been proposed for calculating the sample size required to design a trial with multiple co-primary correlated endpoints. However, because these methods require users to have considerable mathematical sophistication and knowledge of programming techniques, their application and spread may be restricted in practice. To improve the convenience of these methods, in this paper, we provide a useful formula with accompanying numerical tables for sample size calculations to design clinical trials with two treatments, where the efficacy of a new treatment is demonstrated on continuous co-primary endpoints. In addition, we provide some examples to illustrate the sample size calculations made using the formula. Using the formula and the tables, which can be read according to the patterns of correlations and effect size ratios expected in multiple co-primary endpoints, makes it convenient to evaluate the required sample size promptly.  相似文献   
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