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91.
AbstractThis article investigates the development and application of key performance indicators for global product development. Two in-depth, longitudinal case studies with multinational Danish manufacturing companies were conducted, and highlight how key performance indicators, typically used for collocated, cross-functional product development, do not provide the predictive insight required to avoid the additional risks encountered in the global product development environment. Grounded in the case study results and building on established methodologies in performance measurement literature, a framework was developed and validated in two additional Danish companies to support project managers to develop: preventive indicators, which support the avoidance of identified risks, and outcome indicators, which support the measurement towards the attainment of project objectives. The study is unique as it is one of the very few longitudinal studies of engineering design activities in a global context, providing the in-depth contextual understanding towards key risks and their influence on performance; an important step to support researchers and practitioners with the development of preventive measures. 相似文献
92.
For regression on state and transition probabilities in multi-state models Andersen et al. (Biometrika 90:15–27, 2003) propose
a technique based on jackknife pseudo-values. In this article we analyze the pseudo-values suggested for competing risks models
and prove some conjectures regarding their asymptotics (Klein and Andersen, Biometrics 61:223–229, 2005). The key is a second
order von Mises expansion of the Aalen-Johansen estimator which yields an appropriate representation of the pseudo-values.
The method is illustrated with data from a clinical study on total joint replacement. In the application we consider for comparison
the estimates obtained with the Fine and Gray approach (J Am Stat Assoc 94:496–509, 1999) and also time-dependent solutions
of pseudo-value regression equations. 相似文献
93.
This paper considers estimation and prediction in the Aalen additive hazards model in the case where the covariate vector
is high-dimensional such as gene expression measurements. Some form of dimension reduction of the covariate space is needed
to obtain useful statistical analyses. We study the partial least squares regression method. It turns out that it is naturally
adapted to this setting via the so-called Krylov sequence. The resulting PLS estimator is shown to be consistent provided
that the number of terms included is taken to be equal to the number of relevant components in the regression model. A standard
PLS algorithm can also be constructed, but it turns out that the resulting predictor can only be related to the original covariates
via time-dependent coefficients. The methods are applied to a breast cancer data set with gene expression recordings and to
the well known primary biliary cirrhosis clinical data. 相似文献
94.
Liu CA Braun TM 《Journal of the Royal Statistical Society. Series C, Applied statistics》2009,58(2):225-236
We propose a phase I clinical trial design that seeks to determine the cumulative safety of a series of administrations of a fixed dose of an investigational agent. In contrast with traditional phase I trials that are designed solely to find the maximum tolerated dose of the agent, our design instead identifies a maximum tolerated schedule that includes a maximum tolerated dose as well as a vector of recommended administration times. Our model is based on a non-mixture cure model that constrains the probability of dose limiting toxicity for all patients to increase monotonically with both dose and the number of administrations received. We assume a specific parametric hazard function for each administration and compute the total hazard of dose limiting toxicity for a schedule as a sum of individual administration hazards. Throughout a variety of settings motivated by an actual study in allogeneic bone marrow transplant recipients, we demonstrate that our approach has excellent operating characteristics and performs as well as the only other currently published design for schedule finding studies. We also present arguments for the preference of our non-mixture cure model over the existing model. 相似文献
95.
John Ermisch Diego Gambetta Heather Laurie Thomas Siedler S. C. Noah Uhrig 《Journal of the Royal Statistical Society. Series A, (Statistics in Society)》2009,172(4):749-769
Summary. We measure trust and trustworthiness in British society with a newly designed experiment using real monetary rewards and a sample of the British population. The study also asks the typical survey question that aims to measure trust, showing that it does not predict 'trust' as measured in the experiment. Overall, about 40% of people were willing to trust a stranger in our experiment, and their trust was rewarded half of the time. Analysis of variation in the trust behaviour in our survey suggests that trusting is more likely if people are older, their financial situation is either 'comfortable' or 'difficult' compared with 'doing alright' or 'just getting by', they are a homeowner or they are divorced, separated or never married compared with those who are married or cohabiting. Trustworthiness also is more likely among subjects who are divorced or separated relative to those who are married or cohabiting, and less likely among subjects who perceive their financial situation as 'just getting by' or 'difficult'. We also analyse the effect of attitudes towards risks on trust. 相似文献
96.
Thomas M. Philip Danny C. Martinez Eduardo Lopez Antero Garcia 《Race Ethnicity and Education》2016,19(1):182-199
Based on a two-year self-study by a group of early-career scholars of color, we explore and purposefully name our role, within the contemporary context of neoliberal reform, as educational researchers of color who are former K-12 teachers. We capture the insights that emerged from our self-study through a close reading of dominant neoliberal educational reform discourses, particularly through an examination of the writings of Michelle Rhee and Wendy Kopp. Along three dimensions of: (1) experience as teachers; (2) solidarity with teachers; and (3) analyses of racism in schooling, we characterize prominent discourses through which educators, researchers, and the public describe teachers and teaching. We name these discursive frames to make explicit the assumptions that are embedded in each and the intentional or inadvertent consequences of each. Finally, we propose a teacher solidarity lens through which we strive to approach our research and work with teachers. 相似文献
97.
Scheike TH 《Lifetime data analysis》2006,12(4):461-480
I suggest an extension of the semiparametric transformation model that specifies a time-varying regression structure for the
transformation, and thus allows time-varying structure in the data. Special cases include a stratified version of the usual
semiparametric transformation model. The model can be thought of as specifying a first order Taylor expansion of a completely
flexible baseline. Large sample properties are derived and estimators of the asymptotic variances of the regression coefficients
are given. The method is illustrated by a worked example and a small simulation study. A goodness of fit procedure for testing
if the regression effects lead to a satisfactory fit is also suggested. 相似文献
98.
There are obvious reasons why residential construction should depend on the population’s age structure. We estimate this relation
on Swedish time series data and Organization for Economic Cooperation and Development panel data. Large groups of young adults
are associated with higher rates of residential construction, but there is also a significant negative effect from those above
75. Age effects on residential investment are robust and forecast well out-of-sample in contrast to the corresponding house
price results. This may explain why the debate around house prices and demography has been rather inconclusive. Rapidly aging
populations in the industrialized world makes the future look bleak for the construction industry.
相似文献
Bo MalmbergEmail: |
99.
A single latent variable model of health status and therapeutic health care utilization is estimated for parents and own children
of 6,557 US households. The equation system that identifies latent health status simultaneously determines a number of indicators
of general health, including presence of morbidity symptoms, mobility limitations, medication needs, and utilization of therapeutic
health care services. The main goal of the paper was to obtain an unbiased estimate of parents’ marginal substitution rate
between own and child health. Results indicate that parents’ valuation of their children’s health exceeds their valuation
of own health by almost twofold on average.
相似文献
Thomas D. CrockerEmail: |
100.
Population Research and Policy Review - 相似文献