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81.
Recent studies demonstrated that in adults and children recognition of face identity and facial expression mutually interact ( Bate, Haslam, & Hodgson, 2009 ; Spangler, Schwarzer, Korell, & Maier‐Karius, 2010 ). Here, using a familiarization paradigm, we explored the relation between these processes in early infancy, investigating whether 3‐month‐old infants’ ability to recognize an individual face is affected by the positive (happiness) or neutral emotional expression displayed. Results indicated that infants’ face recognition appears enhanced when faces display a happy emotional expression, suggesting the presence of a mutual interaction between face identity and emotion recognition as early as 3 months of age.  相似文献   
82.
This article describes the lessons learned by social work practitioners and nurse researcher faculty from a unique partnership between a 501(c) 3 nonprofit community service organization (cancer helpline) and an academic facility to improve outreach to older adults with cancer. In preparing the research proposal, carrying out the procedures, and instituting a community-based participatory research (CBPR) approach lessons learned included the importance of experienced researchers/writers, unpredictability of research activities, importance of collecting complete data, communicating underlying discipline and role-oriented assumptions, and effectiveness of CBPR to increase outreach to older adults with cancer in Delaware's eight cancer clusters.  相似文献   
83.
Qualitative interview data from 45 matched pairs of survivors disclosing sexual assaults and their primary informal support providers (e.g., friend, family member, significant other) were used to explore survivor and support provider perspectives on changes in sexuality postassault and how those close to them have been affected as a result. Changes in sexuality included loss of interest in sex, increase or change in sexual partners, engaging in sex work, and increased sexual behavior. Support providers generally regarded promiscuity as a risky sexual behavior. If the support provider was the survivor’s sexual partner, he or she discussed exercising caution when navigating sexual intimacy with the survivor. Not all sexual encounters with romantic partners were positive; some survivors discussed being triggered (i.e., with post-traumatic stress disorder [PTSD] flashbacks) or experiencing the dissolution of their relationships due to the sexual impacts of their assault. Counseling implications are discussed in the context of improving survivors’ sexual experiences in general and in romantic relationships postassault. Implications can also be applied to prevention, scholarship on sex work, and sexuality research.  相似文献   
84.
Research on social movement networks has been defined by an emphasis on structural determinism and quantitative methodologies, and has often overlooked the spatial dimension of networking practices. This article argues that scholars have much to gain if (1) they move beyond the understanding of networks as organisational and communication structures, and analyse them as everyday social processes of human negotiation and construction, and (2) they pay attention to how networks between different organisations create multiple and overlapping spaces of action and meaning that define the everyday contexts of social movements. Drawing on ethnographic research within the Cuba Solidarity Campaign, this article explores the everyday dimension of political and communication networks. It shows that everyday networking practices are embedded in processes of identification and meaning construction, and are defined by a politics of inclusion and exclusion; introducing the concept of ethnographic cartography, it demonstrates that social movement networks are incorporated into everyday practices and narratives of place-making.  相似文献   
85.
The aim of the research described here was to examine the issue of social inclusion in relation to young people with a learning difficulty in Guangzhou. Ten families were included in this study based on their willingness to participate. The young people had to be over the age of 16 and not attending school. In each family the young person and a family carer (usually one of the parents) was interviewed separately. The article focuses mainly on the experience and words of the young people who express their feelings towards work and other social contacts. The conclusion is that despite greater government awareness of the needs of people with a disability, and the formulation of social and economic policies designed to encourage inclusion this is far from happening at grassroots level.  相似文献   
86.
There is a growing awareness of the need for designers of organisational change to develop context sensitive approaches to implementation if change is to be successful. Existing change literature indicates that there are many aspects of an organisation’s change context that need to be considered, and a wide range of different implementation options open to those designing change. However, these contextual aspects and design options are not currently pulled together in a comprehensive manner, or in a form that makes them easily accessible to practitioners. This paper builds a framework, called the change kaleidoscope, which aims to achieve this. It illustrates the applicability of this framework in practice as an aid to managers in the development of context sensitive implementation approaches via a case study on the changes undertaken at Glaxo Wellcome UK since the early 1990s. This is an interesting case of a successful organisation that managed to change in a pro-active manner rather than in a crisis driven re-active manner. The paper concludes with the lessons for practitioners on the impact of certain contextual features and design choices during change as illustrated by the Glaxo Wellcome case, and a discussion on the use of the kaleidoscope in practice.  相似文献   
87.
Bayesian finite mixture modelling is a flexible parametric modelling approach for classification and density fitting. Many areas of application require distinguishing a signal from a noise component. In practice, it is often difficult to justify a specific distribution for the signal component; therefore, the signal distribution is usually further modelled via a mixture of distributions. However, modelling the signal as a mixture of distributions is computationally non-trivial due to the difficulties in justifying the exact number of components to be used and due to the label switching problem. This paper proposes the use of a non-parametric distribution to model the signal component. We consider the case of discrete data and show how this new methodology leads to more accurate parameter estimation and smaller false non-discovery rate. Moreover, it does not incur the label switching problem. We show an application of the method to data generated by ChIP-sequencing experiments.  相似文献   
88.
This paper is based on interviews with 10 men all of whom became paraplegic through trauma in adult life. These interviewees and the interviewer are all Hong Kong Chinese. The interviews concentrated on the respondents' sexual adjustment and help they may or may not have received from professionals involved in their treatment and rehabilitation. The author examines the application of the individual and social models of handicap in the specific area of sexuality.  相似文献   
89.
Analysis of the Multistep Process of Carcinogenesis Using Human Fibroblasts   总被引:2,自引:0,他引:2  
Normal human cells in culture have never been neoplastically transformed by carcinogen exposure. One possible explanation is that the life span of such cells is too short for them to acquire the necessary changes. To test this hypothesis, we needed normal human cells with a greatly extended or an infinite life span. We transfected the v- myc gene and a selectable marker into normal human fibroblasts, identified a drug-resistant clone expressing v- myc protein, and passaged the progeny of the clone until they senesced. A few cells continued to proliferate and gave rise to a diploid, infinite life span cell strain, MSU-1.0, that has normal growth control and is nontumorigenic in athymic mice. Analysis showed that one more genetic change, in addition to unregulated expression of the v- myc gene, was involved in generating MSU-1.0 cells. They spontaneously gave rise to a variant strain, designated MSU-1.1, that grows more rapidly and is less dependent on exogenous growth factors. Analysis showed that at least two additional changes were involved in generating this cell strain. It has a stable karyotype composed of 45 chromosomes, including two markers. Transfection of specific oncogenes was used to determine the number and nature of additional changes required to transform MSU-1.1 cells into malignant cells. Analysis indicated that two changes were involved, but no change in karyotype. Exposure of MSU-1.1 cells to a single carcinogen treatment, followed by selection for cells with the characteristics of oncogene-trans-formed MSU-1.1 cells also yielded malignant human cells. We conclude that malignant transformation of normal human fibroblasts requires six or seven genetic changes, some of which involve suppressor genes.  相似文献   
90.
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