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531.
In this paper, we present an algorithm for clustering based on univariate kernel density estimation, named ClusterKDE. It consists of an iterative procedure that in each step a new cluster is obtained by minimizing a smooth kernel function. Although in our applications we have used the univariate Gaussian kernel, any smooth kernel function can be used. The proposed algorithm has the advantage of not requiring a priori the number of cluster. Furthermore, the ClusterKDE algorithm is very simple, easy to implement, well-defined and stops in a finite number of steps, namely, it always converges independently of the initial point. We also illustrate our findings by numerical experiments which are obtained when our algorithm is implemented in the software Matlab and applied to practical applications. The results indicate that the ClusterKDE algorithm is competitive and fast when compared with the well-known Clusterdata and K-means algorithms, used by Matlab to clustering data. 相似文献
532.
Competing risks occur in a time-to-event analysis in which a patient can experience one of several types of events. Traditional methods for handling competing risks data presuppose one censoring process, which is assumed to be independent. In a controlled clinical trial, censoring can occur for several reasons: some independent, others dependent. We propose an estimator of the cumulative incidence function in the presence of both independent and dependent censoring mechanisms. We rely on semi-parametric theory to derive an augmented inverse probability of censoring weighted (AIPCW) estimator. We demonstrate the efficiency gained when using the AIPCW estimator compared to a non-augmented estimator via simulations. We then apply our method to evaluate the safety and efficacy of three anti-HIV regimens in a randomized trial conducted by the AIDS Clinical Trial Group, ACTG A5095. 相似文献
533.
Development of predictive signatures for treatment selection in precision medicine with survival outcomes
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For survival endpoints in subgroup selection, a score conversion model is often used to convert the set of biomarkers for each patient into a univariate score and using the median of the univariate scores to divide the patients into biomarker‐positive and biomarker‐negative subgroups. However, this may lead to bias in patient subgroup identification regarding the 2 issues: (1) treatment is equally effective for all patients and/or there is no subgroup difference; (2) the median value of the univariate scores as a cutoff may be inappropriate if the sizes of the 2 subgroups are differ substantially. We utilize a univariate composite score method to convert the set of patient's candidate biomarkers to a univariate response score. We propose applying the likelihood ratio test (LRT) to assess homogeneity of the sampled patients to address the first issue. In the context of identification of the subgroup of responders in adaptive design to demonstrate improvement of treatment efficacy (adaptive power), we suggest that subgroup selection is carried out if the LRT is significant. For the second issue, we utilize a likelihood‐based change‐point algorithm to find an optimal cutoff. Our simulation study shows that type I error generally is controlled, while the overall adaptive power to detect treatment effects sacrifices approximately 4.5% for the simulation designs considered by performing the LRT; furthermore, the change‐point algorithm outperforms the median cutoff considerably when the subgroup sizes differ substantially. 相似文献
534.
Response‐adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?
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Response‐adaptive randomisation (RAR) can considerably improve the chances of a successful treatment outcome for patients in a clinical trial by skewing the allocation probability towards better performing treatments as data accumulates. There is considerable interest in using RAR designs in drug development for rare diseases, where traditional designs are not either feasible or ethically questionable. In this paper, we discuss and address a major criticism levelled at RAR: namely, type I error inflation due to an unknown time trend over the course of the trial. The most common cause of this phenomenon is changes in the characteristics of recruited patients—referred to as patient drift. This is a realistic concern for clinical trials in rare diseases due to their lengthly accrual rate. We compute the type I error inflation as a function of the time trend magnitude to determine in which contexts the problem is most exacerbated. We then assess the ability of different correction methods to preserve type I error in these contexts and their performance in terms of other operating characteristics, including patient benefit and power. We make recommendations as to which correction methods are most suitable in the rare disease context for several RAR rules, differentiating between the 2‐armed and the multi‐armed case. We further propose a RAR design for multi‐armed clinical trials, which is computationally efficient and robust to several time trends considered. 相似文献
535.
The use of Bayesian nonparametrics models has increased rapidly over the last few decades driven by increasing computational power and the development of efficient Markov chain Monte Carlo algorithms. We review some applications of these models in economic applications including: volatility modelling (using both stochastic volatility models and GARCH-type models) with Dirichlet process mixture models, uses in portfolio allocation problems, long memory models with flexible forms of time-dependence, flexible extension of the dynamic Nelson-Siegel model for interest rate yields and multivariate time series models used in macroeconometrics. 相似文献
536.
In this paper, we study space–time generalized additive models. We apply the penalyzed likelihood method to fit generalized additive models (GAMs) for nonseparable spatio-temporal correlated data in order to improve the estimation of the response and smooth terms of GAMs. The results show that our space–time generalized additive models estimated response and smooth terms reasonable well, and in addition, the mean squared error, mean absolute deviation and coverage intervals improved considerably compared to the classic GAM. An application on particulate matter concentration in the North-Italian region of Piemonte is also presented. 相似文献
537.
Chitra Raghavan Connie J. Beck James Michael Menke Jennifer E. Loveland 《Journal of gay & lesbian social services》2019,31(3):370-395
Using mixed methods, we explored the role of coercive controlling behaviors in a high-risk sample of 126 men in violent same-sex relationships. Contrary to a prediction that separate factors of physical violence and coercive control might emerge, a simple principle components analysis supported that male same-sex relationship intimate partner violence (IPV) is essentially unidimensional. Qualitative narratives supported a single latent factor solution of violence, and that coercive controlling behaviors better detect IPV dynamics within the same violent encounters (i.e., weapon use), even when compared to profiles defined by physical violence. Narratives also highlighted gender-different tactics of coercion used, underscoring importance of context-based assessments. 相似文献
538.
Kathleen H. Powell Ann Bristow Francis L. Precht 《Journal of Community Practice》2019,27(3-4):404-413
ABSTRACTSocial workers can mobilize vulnerable populations to shape policy decisions about industrial practices that could have adverse impacts on their wellbeing. One such practice is hydraulic fracturing or “fracking” to extract oil and natural gas from shale rock deposits. There is scant social work literature on mobilizing opposition to fracking despite a proliferation of literature from other disciplines. This article documents the campaign in Maryland that led to the adoption of the first legislative ban on fracking in a U.S. state with shale gas reserves, using social movement theory to identify factors that led to this successful outcome. 相似文献
539.
Laura L. Bierema 《Human Resource Development International》2020,23(4):347-360
ABSTRACT The COVID-19 pandemic has disrupted life as we knew it and created an unprecedented opportunity to pause and assess ‘normal’ life and work. We have an opportunity to create a new ‘normal.’ What possibility does the chance to show up differently in our lives and work hold? The pandemic has caused significant shifts in values that will affect individuals, organizations, communities, and nations. This article challenges HRD scholars and practitioners to imagine how HRD might create a new normal through bold, critical research inquiry that interrogates exclusion, pursues organization and social justice, and creates humanly sustainable organizations and communities. 相似文献
540.
This article summarizes the four articles in the Social Development quartet focused on positive affect regulation in youth. Each article in the quartet shows that parents’ socialization of youth positive affect (e.g., encouraging, enhancing, savoring, or dampening responses) is associated with youth positive affect regulation and depressive symptoms. Further, three of the studies provide novel evidence for an indirect relationship whereby parental socialization predicts youth depressive symptoms through youth positive affect regulation. The studies include samples of youth across mid‐childhood and adolescence (7–18‐year‐olds) from three countries (the United States, Belgium, and India), and utilize several methods of assessing youth positive affect regulation or parental socialization (parent‐reported surveys, youth‐reported surveys, coded parent–child discussions). This integrative article also identifies several ways in which the study of youth positive affect regulation can be advanced. We address the conceptualization of positive affect regulation and the socialization of children's positive affect, constraints on the adaptiveness of upregulating positive emotions, methodological directions, potential moderated effects based on child characteristics such as sex or temperament, and the importance of studying outcomes beyond depression. 相似文献