Mean shift and influence measures in linear measurement error models with stochastic linear restrictions

We present influence diagnostics for linear measurement error models with stochastic linear restrictions using the corrected likelihood of Nakamura in 1990. The case deletion and mean shift outlier models are developed to identify outlying and influential observations. We derive a corrected score test statistic for outlier detection based on mean shift outlier models. The analogs of Cook's distance and likelihood distance are proposed to determine influential observations based on case deletion models. A parametric bootstrap procedure is used to obtain empirical distributions of the test statistics and a simulation study has been used to evaluate the performance of the proposed estimators based on the mean squares error criterion and the score test statistic. Finally, a numerical example is given to illustrate the theoretical results.     

Conditional Generalized Liouville Distributions on the Simplex

Liouville and generalized Liouville distributions on the simplex have been proposed for modeling compositional data and have been shown to be free from the extreme independence structure that characterizes the Dirichlet class. In this article, generalized Liouville distributions are shown to be rich enough to distinguish some lesser modes of independence as well. Unfortunately, it is noted that the applicability of the Liouville family will be limited, owing to the lack of invariance with respect to the chosen fill-up value. As an alternative, a new family of simplex distributions is proposed, one that admits invariance with respect to choice of fill-up value, as well as the ability to differentiate among many forms of independence.     

Optimal designs for exponential regression

This paper is concerned with the optimal design problem for the particular case of non-linear parametrisation:the parameters to be estimated are included in exponents.Some properties of locally optimal designs as functions of estimated parameters are investigated and a table of such designs in given.We consider also designs to be optimal in the sense of minimax approach.     

On the construction of optimal experimental designs: a penalty approach

Tn optimal experimental design theory there are well-known situations, in which additional constraints are implied to the design set. These constraints destroy in general the simplex structure of the set of feasible points of the design set. Thus the available iteration procedures for the unrestricted case are no longer applicable.

In this paper a penalty approach is suggested which transforms the restricted problem to the unrestricted case and allows the application of well-known algorithms such as the Fedorov-Wynn-type or the projected gradient procedure.     

A representation for quadrivariate normal positive orthant probabilities

For four variables x₁,x₂, x₃ and x₄, which have a quadrivariate normal distribution with means equal to zero, the positive ortrhant probability is the probability that all of the x.'s are simultaneously positive. A representation for the quadrivariate normal positive orthant probability is obtained and it is a function of no more than three integrals over a single variable. Extensive testing has shown this representation to be very efficient on a computational basis.     

Selection of cost-optimal 2k−p fractional factorials

Selecting an optimal 2^k?pfractional factorial is structured as a mathematical programming problem. An algorithm is defined for the solution, and the case of additive costs is shown to have a known solution for resolution III designs.     

Simulations of Some Doubly Stochastic Poisson Point Processes

Computer simulations of point processes are important either to verify the results of certain theoretical calculations that can be very awkward at times or to obtain practical results when these calculations become almost impossible. One of the most common methods for the simulation of nonstationary Poisson processes is random thinning. Its extension when the intensity becomes random (doubly stochastic Poisson processes) depends on the structure of this intensity. If the random density takes only discrete values, which is a common situation in many physical problems where quantum mechanics introduces discrete states, it is shown that the thinning method can be applied without error. We study in particular the case of binary density and present the kind of theoretical calculations that then become possible. The results of various experiments realized with data obtained by simulation show a fairly good agreement with the theoretical calculations.     

Understanding increments in model performance metrics

The area under the receiver operating characteristic curve (AUC) is the most commonly reported measure of discrimination for prediction models with binary outcomes. However, recently it has been criticized for its inability to increase when important risk factors are added to a baseline model with good discrimination. This has led to the claim that the reliance on the AUC as a measure of discrimination may miss important improvements in clinical performance of risk prediction rules derived from a baseline model. In this paper we investigate this claim by relating the AUC to measures of clinical performance based on sensitivity and specificity under the assumption of multivariate normality. The behavior of the AUC is contrasted with that of discrimination slope. We show that unless rules with very good specificity are desired, the change in the AUC does an adequate job as a predictor of the change in measures of clinical performance. However, stronger or more numerous predictors are needed to achieve the same increment in the AUC for baseline models with good versus poor discrimination. When excellent specificity is desired, our results suggest that the discrimination slope might be a better measure of model improvement than AUC. The theoretical results are illustrated using a Framingham Heart Study example of a model for predicting the 10-year incidence of atrial fibrillation.